Structural Bioinformatics and Chemical Biology
Prof. Dr. Matthias Preller
Institute for Biophysical Chemistry, OE4350
Hannover Medical School
Phone (+49) 511 532 2804
Fax (+49) 511 532 5966
Our research focuses on understanding the functions and roles of different proteins during disease development and to specifically design new means to counteract these particular processes. Key to our work is the combination of computational calculations and simulations with experimental methods to rationalize and decipher the underlying molecular and dynamic processes. Therefore, we apply diverse, interdisciplinary methods, including X-ray crystallographic analysis of proteins and protein-ligand complexes, computer-aided drug design, chemical synthesis of small molecule protein modulators, biophysical binding and activity assays, and computational and structural bioinformatics techniques to explore the binding behavior, mechanisms of action, and the function of the target proteins, respectively.