Research profile

Research at the Institute of Molecular and Cellular Physiology focuses on molecular aspects of contraction and motility.

The research spectrum ranges from physiological and pathophysiological functional principles of heart muscle cells and skeletal muscle fibers to the investigation of isolated motor proteins at the single molecule level. A special focus is on the investigation of pathomechanisms of hypertrophic cardiomyopathy (HCM)

 

Physiology and pathophysiology of contraction and motility - from the muscle cell to the individual motor protein

Pathomechanisms of HCM

  • Functional heterogeneity ("contractile imbalance") of cardiomyocytes as a trigger for HCM
  • Longitudinal studies on cellular models and on the HCM large animal model

hPSC cardiomyocytes

  • Maturation and type standardization
  • Cellular disease model      

     

       

          

Molecular function of motor proteins

  • Effects of HCM mutations, isoforms and posttranslational modifications in diseases of the heart and skeletal muscle
  • Structure-function analyses