Prof. Dr. med. vet. Kirsten Haastert-Talini

Curriculum Vitae

1992

University entrance diploma Görres-Gymnasium, Düsseldorf

1992-1995

Academic studies-1    Biology  (intermediate diploma)  Heinrich-Heine-University, Düsseldorf

1995-1999

Academic studies-2    Veterinary medicine (state examination) University of Veterinary Medicine, Hannover

2000-2002

Doctorate.   Clinic for Neurosurgery, Hannover Medical School and Institute for Pharmacology, Toxicology and Pharmacy, University of Veterinary, Title: “In vitro- und In vivo-Studien zur Zellvitalität und Motoneuronenfraktion in ektopen Neuroimplantaten aus embryonalem Rattenrückenmark in Abhängigkeit von Gewinnungsmethoden und pharmakologischen Einflüssen” 

since 2002

Research Associate Institute of Neuroanatomy, Hannover Medical School

2005

Research stay (07-10 2005) Department of Physiological Science & Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, USA (Prof. Fernando Gomez-Pinilla, DFG-research grant)

2009

State doctorate    Specialism Anatomy 

2011

Associate Professor, Institute of Neuroanatomy, Hannover Medical School

 

ORCID

Publons


Current research

Development of new therapeutic strategies to enhance peripheral nerve regeneration after massive substance loss


Selected Publications:

Huang, Z.*, Kankowski, S.*, Ertekin, E., Almog, M., Nevo, Z., Rochkind, S. and Haastert‐Talini, K. (2021), Modified Hyaluronic Acid-Laminin-Hydrogel as Luminal Filler for Clinically Approved Hollow Nerve Guides in a Rat Critical Defect Size Model       Int. J. Mol. Sci. 2021, 22(12), 6554; https://doi.org/10.3390/ijms22126554  "We acknowledge support by the German Research Foundation (DFG) and the Open Access Publication Fund of Hannover Medical School (MHH)“

Ronchi G., Gambarotta G., Morano M., Fregnan F., Pugliese P., Tos P., Geuna S., Haastert-Talini K. (2020). Short communication: Critical analysis of the value of the rabbit median nerve model for biomedical research on peripheral nerve grafts. J Tissue Eng Regen Med. 2020.  https://doi.org/10.1002/term.3036

Dietzmeyer N., Huang Z., Schüning T., Rochkind S., Almog M., Nevo Z., Lieke T., Kankowski S., Haastert-Talini K. (2020) In Vivo and In Vitro Evaluation of a Novel Hyaluronic Acid–Laminin Hydrogel as Luminal Filler and Carrier System for Genetically Engineered Schwann Cells in Critical Gap Length Tubular Peripheral Nerve Graft in Rats. Cell Transplantation, 2020, Volume 29: 1–20. DOI: 10.1177/0963689720910095

Dietzmeyer N,  Förthmann M, Leonhard J, Helmecke O, Brandenberger C.,  Freier T, Haastert-Talini K (2019): Two-Chambered Chitosan Nerve Guides With Increased Bendability Support Recovery Of Skilled Forelimb Reaching Similar To Autologous Nerve Grafts In The Rat 10 mm Median Nerve Injury And Repair Model. Front. Cell. Neurosci. 10 May 2019. doi: 10.3389/fncel.2019.00149  We acknowledge support by the German Research Foundation (DFG) and the Open Access Publication Fund of Hannover Medical School (MHH).

Stößel M, Wildhagen VM, Helmecke O, Metzen J, Pfund CB, Freier T, Haastert-Talini K (2018): Comparative evaluation of chitosan nerve guides with regular or increased bendability for acute and delayed peripheral nerve repair – a comprehensive comparison with autologous nerve grafts and muscle-in-vein grafts.  Anat Rec (Hoboken). 301:1697-1713, 2018. doi: 10.1002/ar.23847. doi.org/10.1002/ar.23847

Stößel M, Rehra L, Haastert-Talini K (2017): Reflex-based grasping, skilled forelimb reaching, and electrodiagnostic evaluation for comprehensive analysis of functional recovery – the 7 mm rat median nerve gap repair model revisited. Brain and Behavior 2017 DOI: 10.1002/brb3.813   onlinelibrary.wiley.com/doi/10.1002/brb3.813/epdf

Stenberg L*, Stößel M*, Ronchi G, Geuna S, Yin Y, Mommert S, Martensson L, Metzen J, Grothe C, Dahlin LB*, Haastert-Talini K* (2017): Regeneration of long-distance peripheral nerve defects after delayed reconstruction in healthy and diabetic rats is supported by immunomodulatory chitosan nerve guides. *Contributed equally, BMC Neurosci  (2017) 18:53; DOI 10.1186/s12868-017-0374-z   rdcu.be/uhr1

Meyer C*, Stenberg L*, Gonzalez-Perez F*, Wrobel S, Ronchi G, Udina E, Suganuma S, Geuna S, Navarro X, Dahlin LB, Grothe C, Haastert-Talini K (2016): Chitosan-film enhanced chitosan nerve guides for long-distance regeneration of peripheral nerves. Biomaterials. 2016 Jan;76:33-51. doi: 10.1016/j.biomaterials.2015.10.040., authors.elsevier.com/a/1RxprWWN0R~xz

Wrobel, S., Serra, S.C., Ribeiro-Samy, S., Sousa, N., Heimann, C., Barwig, C., Grothe, C., Salgado, A.J., Haastert-Talini, K. (2014): In vitro cell-seeded chitosan films for peripheral nerve tissue engineering. Tissue Engineering Part A 20(17-18):2339-49.

Haastert-Talini, K., Geuna, S., Dahlin, L. B., Meyer, C., Stenberg, L., Freier, T., Heimann, C., Barwig, C.,  Pinto, L. F.V., Raimondo, S., Gambarotta, G., Samy, S. R., Sousa, N., Salgado, A. J., Ratzka, A., Wrobel, S., Grothe, C. (2013): Chitosan tubes of varying degrees of acetylation for bridging peripheral nerve defects. Biomaterials 34(38):9886-904

Schmitte R, Tipold A, Stein VM, Schenk H, Flieshardt C, Grothe C, Haastert K (2010): Genetically modified canine Schwann cells - in vitro and in vivo evaluation of their suitability for peripheral nerve tissue engineering.  J Neurosci Methods 2010 Feb;186(2):202-208 

Haastert K, Mauritz C, Chaturvedi S, Grothe C (2007): Adult human and rat Schwann cell cultures - fast and efficient enrichment and highly effective non-viral transfection protocol. Nature Protocols 2 (1), 99-104.

 

 

Books and Book Chapters:

Haastert-Talini, Kirsten, Assmus, Hans, Antoniadis, Gregor (Eds.):  Modern Concepts of Peripheral Nerve Repair. Springer-Verlag GmbH, Heidelberg, 2017 http://www.springer.com/de/book/9783319523187 

Ahmet Bozkurt, Kirsten Haastert-Talini (2014) Kapitel 10: Bioartifizielle Nervenimplantate und alternative Rekonstruktionsverfahren. In: Nervenchirurgie: Trauma, Tumor, Kompression (Kretschmer, Antoniadis, Assmus,eds), Springer Verlag Berlin Heidelberg http://www.springer.com/de/book/9783642368943#otherversion=9783642368950

Stefano Geuna, Kirsten Haastert-Talini, Xavier Navarro (2013) Chapter 4-1: The Nerve Trunk in Injury and During Regeneration. In: Current Treatment of Nerve Injuries and Disorders (Dahlin LB, Leblebicioglu G, eds), Federation of European Societies for Surgery of the Hand, Instructional Courses 2013, Palme Publications

Kirsten Haastert-Talini (2012) Chapter 17: Culture and proliferation of highly purified Schwann cells from rat, dog and man. Methods Mol Biol 2012; 846:189-200. http://www.springer.com/de/book/9781617795350 
 
Kirsten Haastert-Talini (2011) Chapter 10: Experimental Approaches on Tissue engineering Repair of Peripheral Nerve Gaps. In: The Sciatic Nerve: Blocks, Injuries and Regeneration (Fonseca DJ, Martins JL, eds); Series: Neuroscience Research Progress: Nove Science Publishers  Link

 

 

 

Contact

 

 

Prof. Dr. med. vet. Kirsten Haastert-Talini
Institute of Neuroanatomy and Cell Biology, OE 4140  
Building I3, Level H, Room 3110  
Hannover Medical School
Carl-Neuberg-Str. 1  
30625 Hannover, Germany  
Phone: +49-511-532-2891  
Fax: +49-511-532-2880  
Mail: Haastert-Talini.Kirsten@mh-hannover.de