Valentin Burkart

Doctoral student

Contact

Valentin Burkart

Tel:  +49 511 532 -3803 (office), -3654 (lab)

Fax: +49 511 532 -4296

address: 30625 Hannover, Carl-Neuberg-Str.1, Germany

Building J03, level 03, room 1090

Profil bei ResearchGate

 

 

 

Career

  • Doctorate Student since December 2017 at the Institute for Molecular- and Cell Physiology at Hannover Medical School (MHH)
  • 2011 – 2017 Bachelor and Master of Science in Biology at the Technical University of Braunschweig

 

Current Research Focus

  • Analysis of unequal allelic expression of mutant to wildtype allele of the cardiac troponin I gene in single cardiomyocytes from heterozygous HCM patients.
  • Comparison to heart healthy control samples to elucidate, whether unequal allelic expression is HCM induced or a common mechanism in human myocardium.
  • Investigation of active transcription of cardiac troponin I, to resolve possible expression patterns.

 

Expertise

  • Laser-Microdissection, single cell-Reverse Transcription-PCR, Real-Time PCR, Cryosections, Fluorescent in-situ Hybridization.
  • Teaching of practical course for medical- und dentistry students (Muscle 1, smooth muscle)

 

Publications and Abstructs

2019   

  • Hypertrophic Cardiomyopathy: unequal allelic expression and contractile imbalance from cell-to-cell for myosin-binding protein C and cardiac troponin I mutations; V. Burkart, J. Beck, D. Aldag-Niebling, A. Radocaj, B. Piep, C. dos Remedios, D. Hilfiker-Kleiner, V. D. V. Jolanda, J. Montag, T. Kraft; Acta Physiologica; 2019
  • Allelic Imbalance of TNNI3 through burst-like transcription may lead to contractile imbalance in Hypertrophic Cardiomyopathy patients; V. Burkart, J.Beck, K. Kowalski, J. van der Velden, C. G. dos Remedios, J. Montag, T. Kraft; Journal of muscle research and cell motility; 2019
  • Contractile imbalance as trigger for HCM pathogenesis: evidence from mutations in different sarcomeric proteins; Montag J, Burkart V, Beck J, Aldag-Niebling D, Piep B, Keyser B, des Remedios C, Hilfiker-Kleiner D, van der Velden J, Kraft T.; Eur Heart J:40 (Supp); 2019

2020

  • Unequal allelic expression of cardiac troponin I with heterozygous mutation inducing contractile imbalance from cell-to-cell may lead to Hypertrophic Cardiomyopathy; V. Burkart, J.Beck, K. Kowalski, J. van der Velden, C. G. dos Remedios, J. Montag, T. Kraft; Biophysical Journal 118(3):424a; 2020