Dr. Issam Ismail

1. Fiddicke M, Fleissner F, Brunkhorst T, Kühn EM, Obed D, Boethig D, Ismail I, Haverich A, Warnecke G, Sommer W. Coronary artery bypass grafts to chronic occluded right coronary arteries. JTCVS. 2021. June 09,

2. Ismail I , Wert L, Hanke JS, Dogan G, Chatterjee A, Feldmann C, Cebotari S, Haverich A, Schmitto JD. Mid-term Outcome of the Edge-To-Edge Mitral Valve Repair Via Aortic Outflow Tract in High-Risk Patients. Semin Thorac Cardiovasc Surg. 2021 Jun 2:S1043-0679(21)00251-3

3. Fleissner F, Frank P, Haverich A, Ismail I . Echocardiographic guided, transatrial closure of a patent foramen ovale. J Cardiothorac Surg. 2020 Sep 14;15(1):255.

4. Weber N, Kowalski K, Holler T, Radocaj A, Fischer M, Thiemann S, de la Roche J, Schwanke K, Piep B, Peschel N, Krumm U, Lingk A, Wendland M, Greten S, Schmitto JD, Ismail I , Warnecke G, Zywietz U, Chichkov B, Meißner J, Haverich A, Martin U, Brenner B, Zweigerdt R, Kraft T. Advanced Single-Cell Mapping Reveals that in hESC Cardiomyocytes Contraction Kinetics and Action Potential Are Independent of Myosin Isoform. Stem Cell Reports. 2020 May 12;14(5):788-802.

5. Obed D, Fleissner F, Martens A, Cebotari S, Haverich A, Warnecke G, Ismail I . Total Arterial Revascularization with Radial Artery and Internal Thoracic Artery T-Grafts Is Associated with Superior Long-Term Survival in Patients Undergoing Coronary Artery Bypass Grafting. Ann Thorac Cardiovasc Surg. 2020 Feb 20;26(1):30-39.

6. Rojas SV, Trinh-Adams ML, Uribarri A, Fleissner F, Iablonskii P, Rojas-Hernandez S, Ricklefs M, Martens A, Rümke S, Warnecke G, Cebotari S,Haverich A, Ismail I . Early surgical myocardial revascularization in non-STsegment elevation acute coronary syndrome. J Thorac Dis. 2019 Nov;11(11):4444-4452.

7. Salman J, Fleißner F, Naqizadah J, Avsar M, Shrestha M, Warnecke G, Ismail I , Rümke S, Cebotari S, Haverich A, Tudorache I. Minimally Invasive Mitral Valve Surgery in Re-Do Cases-The New Standard Procedure? Thorac Cardiovasc Surg. 2018 Oct;66(7):545-551.

8. Wert L, Hanke JS, Dogan G, Ricklefs M, Chatterjee A, Feldmann C, Ismail I, Napp LC, Haverich A, Schmitto JD. Argatroban administration as therapy for thrombosis in patients with continuous-flow ventricular assist devices. J Thorac Dis. 2018 Jun;10(Suppl 15):S1720-S1727.

9. Mashaqi B, Ismail I , Siemeni TT, Ruemke S, Fleissner F, Zhang R, Wiegmann B, Filitz J, Gottlieb J, Haverich A. Local Anesthetics delivered through Pleural Drainages improve Pain and Lung Function after Cardiac Surgery. Thorac Cardiovasc Surg. 2018 Mar;66(2):198-202.

10. Madrahimov N, Boyle EC, Gueler F, Goecke T, Knöfel AK, Irkha V, Maegel L, Höffler K, Natanov R, Ismail I , Maus U, Kühn C, Warnecke G, Shrestha ML, Cebotari S, Haverich A. Novel mouse model of cardiopulmonary bypass. Eur J Cardiothorac Surg. 2018 Jan 1;53(1):186-193.

11. Beckmann E, Ismail I , Cebotari S, Busse A, Martens A, Shrestha M, Kühn C, Haverich A, Fegbeutel C. Right-Sided Heart Failure and Extracorporeal Life Support in Patients Undergoing Pericardiectomy for Constrictive Pericarditis: A Risk Factor Analysis for Adverse Outcome. Thorac Cardiovasc Surg. 2017 Dec;65(8):662-670.

12. Madrahimov N, Natanov R, Boyle EC, Goecke T, Knöfel AK, Irkha V, Solovieva A, Höffler K, Maus U, Kühn C, Ismail I , Warnecke G, Shrestha ML, Cebotari S, Haverich A. Cardiopulmonary Bypass in a Mouse Model: A Novel Approach. J Vis Exp. 2017 Sep 22;(127):56017.

13. Beckmann E, Rustum S, Marquardt S, Merz C, Shrestha M, Martens A, Haverich A, Ismail I . Surgical treatment of coronary artery aneurysms. J Card Surg. 2017 Nov;32(11):674-679.

14. Ius F, Schulz J, Roumieh M, Fleissner F, Ismail I , Tudorache I, Warnecke G, Martens A, Shrestha M, Boethig D, Haverich A, Cebotari S. Long-term results of the Mitroflow aortic pericardial bioprosthesis in over 800 patients: limited durability and mechanisms of dysfunction. Eur J Cardiothorac Surg. 2017 Aug 1;52(2):264-271.

15. Hanke JS, Krabatsch T, Rojas SV, Deniz E, Ismail I , Martens A, Shrestha M, Haverich A, Netuka I, Schmitto JD. In Vitro Evaluation of Inflow Cannula Fixation Techniques in Left Ventricular Assist Device Surgery. Artif Organs. 2017 Mar;41(3):272-275.

16. Fleißner F, Ismail I , Martens A, Cebotari S, Haverich A, Shrestha M. The unplanned postoperative coronary angiogram after CABG: Identifying the patients at risk .The GermanyThorac Cardiovasc Surg 2017;65:292–295.

17. Rustum S, Fleissner F, Beckmann E, Ius F, Wilhelmi W, Cebotari S, Haverich A, Ismail I . Is There an Upper Limit to Cardiopulmonary Bypass Times? Jan 20217. Ann Circ 2(1): 003-007. DOI: 10.17352/ac.000004.

18. Umminger J, Reitz M, Rojas SV, Stiefel P, Shrestha M, Haverich A, Ismail I, Martens A. Does the surgeon's experience have an impact on outcome after total arterial revascularization with composite T-grafts? A risk factor analysis. Interact Cardiovasc Thorac Surg. 2016 Nov;23(5):749-756.

19. Ius F, Koigeldiyev N, Roumieh M, Ismail I, Tudorache I, Shrestha M, Fleissner F, Haverich A, Cebotari S. Impact of sinuses of Valsalva on prosthesis durability in patients undergoing ascending aorta and aortic valve replacement with Carpentier-Edwards bioprosthesis: a propensity scorebased study. Eur J Cardiothorac Surg. 2016 Jun;49(6):1676-84.

20. Fleissner F, Reitz M, Cebotari S, Kaufeld T, Haverich A, Shrestha M, Ismail I, Martens A. Total Arterial Revascularization with Radial Artery T-grafts in Patients with Significant Left Main Stem Stenosis Is Not Associated with Higher Perioperative Risk. Thorac Cardiovasc Surg. 2016 Apr;64(3):197-203.

21. Fleissner F, Engelke H, Rojas-Hernandez S, Ismail I , Stiefel P, Cebotari S, Haverich A, Shrestha M, Martens A. Long-term follow-up of total arterial revascularization with left internal thoracic artery and radial artery T-grafts: survival, cardiac morbidity and quality of life. Eur J Cardiothorac Surg. 2016 Apr;49(4):1195-200.

22. Hanke JS, Rojas SV, Avsar M, Bara C, Ismail I , Haverich A, Schmitto JD. HeartWare left ventricular assist device for the treatment of advanced heart failure. Future Cardiol. 2016 Jan;12(1):17-26.

23. Roumieh M, Ius F, Tudorache I, Ismail I , Fleissner F, Haverich A, Cebotari S. Comparison between biological and mechanical aortic valve prostheses in middle-aged patients matched through propensity score analysis: longterm results. Eur J Cardiothorac Surg. 2015 Jul;48(1):129-36.

24. Fleissner F, Warnecke G, Cebotari S, Rustum S, Haverich A, Ismail I . Coronary artery bypass grafting in young patients--insights into a distinct entity. J Cardiothorac Surg. 2015 May 1;10:65.

25. Ismail I , Fleissner F, Cebotari S, Rustum S, Haverich A. Left-sided minimaze procedure via the left atrial appendage. Interact Cardiovasc Thorac Surg. 2014 Jun;18(6):847-9.

26. Akhyari P, Lichtenberg A, Hartmann A, Ismail I , Hiroyuki K, Minol JP, Kofidis T, Klima U, Karck M, Haverich A. Influence of prosthesis type on long-term survival after re-replacement of aortic valve prosthesis. Heart Surg Forum. 2013 Dec;16(6):E298-302.

27. Emmert MY, Emmert LS, Martens A, Ismail I , Schmidt-Richter I, Gawol A, Seifert B, Haverich A, Martin U, Gruh I. Higher frequencies of BCRP+ cardiac resident cells in ischaemic human myocardium. Eur Heart J. 2013 Sep;34(36):2830-8.

28. Fleissner F, Ius F, Haverich A, Ismail I . Extension of the right internal thoracic artery with the radial artery in extensive re-do coronary artery bypass grafting. J Cardiothorac Surg. 2013 Jul 12;8:173.

29. Khaladj N, Ismail I , Shrestha M, Peterss S, Pichlmaier M, Kallenbach K, Haverich A, Hagl C. Aortic root surgery in combination with hypothermic circulatory arrest: preserve or replace the aortic valve in the context of postoperative neurological outcome? A case match comparison. Interact Cardiovasc Thorac Surg. 2009 Aug;9(2):246-50


Fallberichte (peer -reviewed)

1. Fleissner F, Schmitto JD, Napp C, Ismail I . Rupture of the Free Left Ventricular Wall: A Novel Approach for Reconstruction. Thorac Cardiovasc Surg Rep. 2018 Jan; 7(1): e30–e32.
2. Mogaldea A, Ruemke S, Haverich A, Ismail I . Concomitant Repair of a Ventricular Septal Defect during Emergency Coronary Artery Bypass Grafting and Left Ventricular Aneurysm Resection. Case Rep Acute Med 2018;1:7–10
3. Fleissner F, Mashaqi B, Merz C, Haverich A, Ismail I . Minimally Invasive Treatment of a Left-Ventricular Aneurysm Via a Left- Thoracic Thoracotomy as Re-Do. January 2017. DOI:10.4172/2165-7920.1000939.
4. Wilhelmi M, Rodt T, Ismail I , Haverich A. Aortic valve replacement via right anterolateral thoracotomy in the case of a patient with extreme mediastinal right-shift following pneumonectomy. Journal of Cardiothoracic Surgery volume 8, Article number: 20 (2013).
5. Bobylev D, Fleissner F, Zhang R, Haverich A, Ismail I . Arterial myocardial revascularization with right internal thoracic artery and epigastric artery in a patient with Leriche's syndrome. J Cardiothorac Surg. 2013 Mar 23; 8:53.- 53.
6. Zardo P, Zhang R, Ismail I , Fischer S. Extensive metastasectomy for a single lesion with cardiac invasion. Thorac Cardiovasc Surg 2012 Sep;60(6):419-20.
7. Ismail I , Zhang R, Ringe K, Fischer S, Haverich A. Retrosternal adhesiolysis through an anterior minithoracotomy: a novel approach facilitating complete median redo sternotomy with a patent internal thoracic artery graft. The Journal of thoracic and cardiovascular Surgery, 2009, 137 (4), 1034-1035.
8. Zhang R, Zardo P, Haverich A, Ismail I . Elongation of right internal thoracic artery with radial artery for redo total arterial revascularization in patients with open left internal thoracic artery to left anterial descending artery graft. Eur J Cardiothorac Surg. 2009 Jul;36(1):206-7.


Übersichtsarbeiten (peer -reviewed)
1. Fleissner F, Ismail I . Acute surgical myocardial revascularization - For whom, when and why? (Akute operative Myokardrevaskularisation. Für wen, wann und warum?) Zeitschrift für Herz-,Thorax- und Gefäßchirurgie volume 33, pages 311–312 (2019).
2. Wiegmann B, Ismail I , Haverich A, Cardiac surgery in the elderly. Der Chirurg 2017. Volume 88, pages 110–115 (2017).


1. Ismail I , Haverich A. Pathology and Classification of Mitral Valve Disease, Mitral Valve Surgery, Pages 21-29, Springer 2011
2. Fleissner F, Ismail I . Aktuelle Entwicklungen in der Indikationsstellung zur operativen Myokardrevaskularisation: Lehren aus der Vergangenheit für eine bessere Versorgung in der Zukunft. Was gibt es Neues in der Chirurgie, 2021


Publizierte Abstrakta von Vorträgen
1. Ismail F, Heuer W, Stumpp N, Eberhard J, Winkel A, Bremer F, Ismail I , Haverich A, Stiesch M. Metagenomic analysis of oral biofilms in patients with artery diseases. July 2010 - Conference: IADR General Session 2010.
2. Fleissner F, Merhej H, Martens A, Cebotari S, Haverich A, Ismail I . Redo Coronary Artery Bypass Grafting in 416 Patients: An Individualized Approach Evolving Over Time. Thorac Cardiovasc Surg 2021; 69(S 01): S1-S85 DOI:10.1055/s-0041-1725742.
3. Fleissner F, Rümke S, Mogaldea A, Cebotari S, Ismail I , Warnecke G, Haverich A, Kühn C ECLS Supported Transport of Intensive Care Unit Patients—Is It Worth the Effort? Thorac Cardiovasc Surg 2019; 67(S 01): S1-S100 .