The lab's main interests are two classes of ligand-gated cation channels, hyperpolarization-activated and cyclic nucleotide-gated cation (HCN) channels and endo-lysosomal cation channels such as two-pore-loop (TPC) and TRPML channels (the mucolipin family of Transient Receptor Potential (TRPML) channels). In addition, we work on voltage-gated sodium channels, voltage-gated calcium channels and chloride channels. Work from our laboratory and results from the literature strongly suggest that these classes of channels represent highly interesting drug targets.
Our work combines basic research and translational approaches to identify mechanisms underlying normal physiological function and also clinically relevant human diseases prevalent in western countries such as non-alcoholic fatty liver hepatitis, hyperlipoproteinemia, atherosclerosis, epilepsy as well as rare diseases such as congenital stationary night blindness and Ebola hemorrhagic fever. For these projects, my group utilizes a series of preclinical models and conducts studies involving human patients as well as human tissues and cells.