-
Böhm S, Splith V, Riedmayr LM, Rötzer RD, Gasparoni G, Nordström KJV, Wagner JE, Hinrichsmeyer KS, Walter J, Wahl-Schott C, Fenske S, Biel M, Michalakis S, Becirovic E. 2020. „A gene therapy for inherited blindness using dCas9-VPR-mediated transcriptional activation”. Sci Adv. 2020 Aug 19;6(34):eaba5614. https://doi.org/10.1126/sciadv.aba5614
-
Arlt E, Fraticelli M, Tsvilovskyy V, Nadolni W, Breit A, O'Neill TJ, Resenberger S, Wennemuth G, Wahl-Schott C, Biel M, Grimm C, Freichel M, Gudermann T, Klugbauer N, Boekhoff I, Zierler S. 2020. „TPC1 deficiency or blockade augments systemic anaphylaxis and mast cell activity”. Proc Natl Acad Sci U S A. 2020 Jul 28;117(30):18068-18078. https://doi.org/10.1073/pnas.1920122117
-
Gerndt S, Chen CC, Chao YK, Yuan Y, Burgstaller S, Scotto Rosato A, Krogsaeter E, Urban N, Jacob K, Nguyen ONP, Miller MT, Keller M, Vollmar AM, Gudermann T, Zierler S, Schredelseker J, Schaefer M, Biel M, Malli R, Wahl-Schott C, Bracher F, Patel S, Grimm C. „Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function”. Elife. 2020 Mar 16;9:e54712. https://doi.org/10.7554/elife.54712
-
Grieschat M, Guzman RE, Langschwager K, Fahlke C, Alekov AK. 2020. „Metabolic energy sensing by mammalian CLC anion/proton exchangers”. EMBO Rep. 2020 Jun 4;21(6):e47872. https://doi.org/10.15252/embr.201947872
-
Gorinski N, Wojciechowski D, Guseva D, Abdel Galil D, Mueller FE, Wirth A, Thiemann S, Zeug A, Schmidt S, Zareba-Kozioł M, Wlodarczyk J, Skryabin BV, Glage S, Fischer M, Al-Samir S, Kerkenberg N, Hohoff C, Zhang W, Endeward V, Ponimaskin E. 2020. „DHHC7-mediated palmitoylation of the accessory protein barttin critically regulates the functions of ClC-K chloride channels“. J Biol Chem. 2020 May 1;295(18):5970-5983. https://doi.org/10.1074/jbc.ra119.011049
-
Weber, N., Kowalski, K., Holler, T., Radocaj, A., Fischer, M., Thiemann, S., de la Roche, J., Schwanke, K., Piep, B., Peschel, N., Krumm, U., Lingk, A., Wendland, M., Greten, S., Schmitto, J. D., Ismail, I., Warnecke, G., Zywietz, U., Chichkov, B., Meissner, J., Haverich, A., Martin, U., Brenner, B., Zweigerdt, R., and Kraft, T. 2020. „Advanced Single-Cell Mapping Reveals that in hESC Cardiomyocytes Contraction Kinetics and Action Potential Are Independent of Myosin Isoform”. Stem Cell Reports 14, 788-802. https://doi.org/10.1016/j.stemcr.2020.03.015
-
Foinquinos, A., Batkai, S., Genschel, C., Viereck, J., Rump, S., Gyongyosi, M., Traxler, D., Riesenhuber, M., Spannbauer, A., Lukovic, D., Weber, N., Zlabinger, K., Hasimbegovic, E., Winkler, J., Fiedler, J., Dangwal, S., Fischer, M., de la Roche, J., Wojciechowski, D., Kraft, T., Garamvolgyi, R., Neitzel, S., Chatterjee, S., Yin, X., Bar, C., Mayr, M., Xiao, K., and Thum, T. 2020. „Preclinical development of a miR-132 inhibitor for heart failure treatment”. Nat Commun 11, 633. https://doi.org/10.1038/s41467-020-14349-2
-
Hammelmann V, Stieglitz MS, Hülle H, Le Meur K, Kass J, Brümmer M, Gruner C, Rötzer RD, Fenske S, Hartmann J, Zott B, Lüthi A, Spahn S, Moser M, Isbrandt D, Ludwig A, Konnerth A, Wahl-Schott C, Biel M. 2019. „Abolishing cAMP sensitivity in HCN2 pacemaker channels induces generalized seizures”. JCI Insight. 2019 May 2;4(9):e126418. https://doi.org/10.1172/jci.insight.126418
-
Krogsaeter EK, Biel M, Wahl-Schott C, Grimm C. 2019. „The protein interaction networks of mucolipins and two-pore channels”. Biochim Biophys Acta Mol Cell Res. 2019 Jul;1866(7):1111-1123. https://doi.org/10.1016/j.bbamcr.2018.10.020
-
Halloin, C., Schwanke, K., Lobel, W., Franke, A., Szepes, M., Biswanath, S., Wunderlich, S., Merkert, S., Weber, N., Osten, F., de la Roche, J., Polten, F., Christoph Wollert, K., Kraft, T., Fischer, M., Martin, U., Gruh, I., Kempf, H., and Zweigerdt, R. 2019. „Continuous WNT Control Enables Advanced hPSC Cardiac Processing and Prognostic Surface Marker Identification in Chemically Defined Suspension Culture”. Stem Cell Reports 13, 366-379. https://doi.org/10.1016/j.stemcr.2019.06.004
-
Fricke, T. C., Echtermeyer, F., Zielke, J., de la Roche, J., Filipovic, M. R., Claverol, S., Herzog, C., Tominaga, M., Pumroy, R. A., Moiseenkova-Bell, V. Y., Zygmunt, P. M., Leffler, A., and Eberhardt, M. J. 2019. “Oxidation of methionine residues activates the high-threshold heat-sensitive ion channel TRPV2”. Proc Natl Acad Sci U S A 2019 Nov 26;116(48):24359-24365 https://doi.org/10.1073/pnas.1904332116
-
Engels, L., Olmer, R., de la Roche, J., Gohring, G., Ulrich, S., Haller, R., Martin, U., and Merkert, S. 2019.„Generation of a CFTR knock-in reporter cell line (MHHi006-A-1) from a human induced pluripotent stem cell line”. Stem Cell Res 40, 101542 https://doi.org/10.1016/j.scr.2019.101542w
-
de la Roche, J., Angsutararux, P., Kempf, H., Janan, M., Bolesani, E., Thiemann, S., Wojciechowski, D., Coffee, M., Franke, A., Schwanke, K., Leffler, A., Luanpitpong, S., Issaragrisil, S., Fischer, M., and Zweigerdt, R. 2019.„Comparing human iPSC-cardiomyocytes versus HEK293T cells unveils disease-causing effects of Brugada mutation A735V of NaV1.5 sodium channels”. Sci Rep 9, 11173 https://doi.org/10.1038/s41598-019-47632-4
-
Stieglitz MS, Fenske S, Hammelmann V, Becirovic E, Schöttle V, Delorme JE, Schöll-Weidinger M, Mader R, Deussing J, Wolfer DP, Seeliger MW, Albrecht U, Wotjak CT, Biel M, Michalakis S, Wahl-Schott C.2018. „Disturbed Processing of Contextual Information in HCN3 Channel Deficient Mice”. Front Mol Neurosci. 2018 Jan 9;10:436. https://doi.org/10.3389/fnmol.2017.00436
-
Wojciechowski D, Thiemann S, Schaal C, Rahtz A, de la Roche J, Begemann B, Becher T, Fischer M. 2018. „Activation of renal ClC-K chloride channels depends on an intact N terminus of their accessory subunit barttin”. J Biol Chem. 2018 Jun 1;293(22):8626-8637. https://doi.org/10.1074/jbc.ra117.000860
-
Beer LA, Tatge H, Schneider C, Ruschig M, Hust M, Barton J, Thiemann S, Fühner V, Russo G, Gerhard R. 2018. „The Binary Toxin CDT of Clostridium Difficile as a Tool for Intracellular Delivery of Bacterial Glucosyltransferase Domains”. Toxins (Basel). 2018 Jun 1;10(6):225. https://doi.org/10.3390/toxins10060225
-
Hanff E, Zinke M, Böhmer A, Niebuhr J, Maassen M, Endeward V, Maassen N, Tsikas D. 2018. „GC-MS determination of nitrous anhydrase activity of bovine and human carbonic anhydrase II and IV”. Anal Biochem. 2018 Jun 1;550:132-136. https://doi.org/10.1016/j.ab.2018.05.001
-
Arias-Hidalgo M, Al-Samir S, Gros G, Endeward V. 2018. „Cholesterol is the main regulator of the carbon dioxide permeability of biological membranes”. Am J Physiol Cell Physiol. 2018 Aug 1;315(2):C137-C140. https://doi.org/10.1152/ajpcell.00139.2018
-
Lin HA, Déan-Ben XL, Reiss M, Schöttle V, Wahl-Schott CA, Efimov IR, Razansky D. 2018. „Ultrafast Volumetric Optoacoustic Imaging of Whole Isolated Beating Mouse Heart”. Sci Rep. 2018 Sep 20;8(1):14132. https://doi.org/10.1038/s41598-018-32317-1
-
Wojciechowski D, Kovalchuk E, Yu L, Tan H, Fahlke C, Stölting G, Alekov AK. 2018. „Barttin Regulates the Subcellular Localization and Posttranslational Modification of Human Cl-/H+ Antiporter ClC-5“. Front Physiol. 2018 Oct 23;9:1490. https://doi.org/10.3389/fphys.2018.01490
-
Plesch E, Chen CC, Butz E, Scotto Rosato A, Krogsaeter EK, Yinan H, Bartel K, Keller M, Robaa D, Teupser D, Holdt LM, Vollmar AM, Sippl W, Puertollano R, Medina D, Biel M, Wahl-Schott C, Bracher F, Grimm C. 2018. „Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells“. Elife. Nov 27;7:e39720. https://doi.org/10.7554/elife.39720
-
Arias-Hidalgo M, Yuan Q, Carta F, Supuran CT, Gros G, Endeward V. 2018. „CO2 Permeability of Rat Hepatocytes and Relation of CO2 Permeability to CO2 Production”. Cell Physiol Biochem. 2018;46(3):1198-1208. https://doi.org/10.1159/000489070
-
Ruhe F, Olling A, Abromeit R, Rataj D, Grieschat M, Zeug A, Gerhard R, Alekov A. 2017. „Overexpression of the Endosomal Anion/Proton Exchanger ClC-5 Increases Cell Susceptibility toward Clostridium difficile Toxins TcdA and TcdB”. Front Cell Infect Microbiol. 2017 Mar 13;7:67. https://doi.org/10.3389/fcimb.2017.00067
-
Endeward V, Arias-Hidalgo M, Al-Samir S, Gros G. 2017. „CO₂ Permeability of Biological Membranes and Role of CO₂ Channels”. Membranes (Basel). 2017 Oct 24;7(4):61. https://doi.org/10.3390/membranes7040061
-
Herrmann S, Rajab H, Christ I, Schirdewahn C, Höfler D, Fischer MJM, Bruno A, Fenske S, Gruner C, Kramer F, Wachsmann T, Wahl-Schott C, Stieber J, Biel M, Ludwig A. 2017. „Protein kinase A regulates inflammatory pain sensitization by modulating HCN2 channel activity in nociceptive sensory neurons”. Pain. 2017 Oct;158(10):2012-2024. https://doi.org/10.1097/j.pain.0000000000001005
-
Jara-Avaca, M., Kempf, H., Ruckert, M., Robles-Diaz, D., Franke, A., de la Roche, J., Fischer, M., Malan, D., Sasse, P., Solodenko, W., Drager, G., Kirschning, A., Martin, U., and Zweigerdt, R. 2017. „EBIO Does Not Induce Cardiomyogenesis in Human Pluripotent Stem Cells but Modulates Cardiac Subtype Enrichment by Lineage-Selective Survival”. Stem Cell Reports 8, 305-317 https://doi.org/10.1016/j.stemcr.2016.12.012
-
Stoetzer, C., Martell, C., de la Roche, J., and Leffler, A. 2017. „Inhibition of Voltage-Gated Na+ Channels by Bupivacaine Is Enhanced by the Adjuvants Buprenorphine, Ketamine, and Clonidine”. Reg Anesth Pain Med 42, 462-468 https://doi.org/10.1097/aap.0000000000000596
-
Eberhardt, M. J., Schillers, F., Eberhardt, E. M., Risser, L., de la Roche, J., Herzog, C., Echtermeyer, F., and Leffler, A. 2017. „Reactive metabolites of acetaminophen activate and sensitize the capsaicin receptor TRPV1”. Sci Rep 7, 12775 https://doi.org/10.1038/s41598-017-13054-3
-
Eberhardt, M., Stueber, T., de la Roche, J., Herzog, C., Leffler, A., Reeh, P. W., and Kistner, K. 2017. „TRPA1 and TRPV1 are required for lidocaine-evoked calcium influx and neuropeptide release but not cytotoxicity in mouse sensory neurons”. PLoS One 12, e0188008 https://doi.org/10.1371/journal.pone.0188008
-
Becirovic, Elvir, Sybille Böhm, Ong N. P. Nguyen, Lisa M. Riedmayr, Verena Hammelmann, Christian Schön, Elisabeth S. Butz, Christian Wahl-Schott, Martin Biel, und Stylianos Michalakis. 2016. „AAV Vectors for FRET-Based Analysis of Protein-Protein Interactions in Photoreceptor Outer Segments“. Frontiers in Neuroscience 10: 356. https://doi.org/10.3389/fnins.2016.00356.
-
Butz, Elisabeth S., Manu Ben-Johny, Michael Shen, Philemon S. Yang, Lingjie Sang, Martin Biel, David T. Yue, und Christian Wahl-Schott. 2016. „Quantifying Macromolecular Interactions in Living Cells Using FRET Two-Hybrid Assays“. Nature Protocols 11 (12): 2470–98. https://doi.org/10.1038/nprot.2016.128.
-
Fenske, Stefanie, Rasmus Pröbstle, Franziska Auer, Sami Hassan, Vanessa Marks, Danius H. Pauza, Martin Biel, und Christian Wahl-Schott. 2016. „Comprehensive Multilevel in Vivo and in Vitro Analysis of Heart Rate Fluctuations in Mice by ECG Telemetry and Electrophysiology“. Nature Protocols 11 (1): 61–86. https://doi.org/10.1038/nprot.2015.139.
-
Sakurai, Yasuteru, Andrey A. Kolokoltsov, Cheng-Chang Chen, Michael W. Tidwell, William E. Bauta, Norbert Klugbauer, Christian Grimm, Christian Wahl-Schott, Martin Biel, und Robert A. Davey. 2015. „Two pore channels control Ebolavirus host cell entry and are drug targets for disease treatment“. Science (New York, N.Y.) 347 (6225): 995–98. https://doi.org/10.1126/science.1258758.
-
Chen, Cheng-Chang, Marco Keller, Martin Hess, Raphael Schiffmann, Nicole Urban, Annette Wolfgardt, Michael Schaefer, u. a. 2014. „A Small Molecule Restores Function to TRPML1 Mutant Isoforms Responsible for Mucolipidosis Type IV“. Nature Communications 5 (August): 4681. https://doi.org/10.1038/ncomms5681.
-
Grimm, Christian, Lesca M. Holdt, Cheng-Chang Chen, Sami Hassan, Christoph Müller, Simone Jörs, Hartmut Cuny, u. a. 2014. „High Susceptibility to Fatty Liver Disease in Two-Pore Channel 2-Deficient Mice“. Nature Communications 5 (August): 4699. https://doi.org/10.1038/ncomms5699.
- Fenske, Stefanie, Stefanie C. Krause, Sami I. H. Hassan, Elvir Becirovic, Franziska Auer, Rebekka Bernard, Christian Kupatt, u. a. 2013. „Sick Sinus Syndrome in HCN1-Deficient Mice“. Circulation 128 (24): 2585–94. https://doi.org/10.1161/CIRCULATIONAHA.113.003712.