Modulation of chromatin organization by SUMO pathway in myofibril assembly and muscle atrophy

 

Research focus / Forschungsschwerpunkte

Mobility is an indispensable feature that determines survival and success in the animal world. Skeletal muscle that allows this mobility accounts for 40% of human body mass. Apart from movement, another feature of the muscle power is to be able to bear the load. The skeletal muscle displaying a characteristic striated pattern is an array of linearly arranged units called ‘sarcomeres’. The individual sarcomere hosts highly organized structures including the actin, and myosin filaments. The cyclic interaction between these two types of filaments is responsible for generation of force and movement at the molecular to organismic level.

Precise molecular arrangement of sarcomere is central to the muscle function. Importantly, disorganization of sarcomere and thereby defective muscle function are the typical hallmarks of myopathies including cancer cachexia, prevalent in nearly 80% of patients.

Our group aims to understand how SUMO (Small Ubiquitin-like Modifier)-mediated epigenetic program regulates sarcomere organization and how it is deregulated in muscle atrophy/cachexia.

 

Lab Projects:

 

Lab stuff / Labor Mitarbeiter

PhD student: We are currently hiring talented doctoral students.

Stefanie Nedel: technical assistant

With her excellent technical expertise in cell and molecular biology Stefanie is involved in various projects of the group.

 

Lab Methodologies:

We employ various experimental approaches including quantitative proteomics, epigenomics (ChIPseq, chromosome conformation capture etc.) and single molecule biophysical methods such as total internal reflection fluorescence microscopy (TIRFM) to address our questions.​

 

Funding:

Our lab is funded by research grant from the German Research Foundation (DFG).

 

Veröffentlichungen /Selected publications

 

Collaboration: