October 2019

Congratulations for Prof. Thomas Thum reaching the 10 year jubilee at Hannover Medical School!


October 2019 The European Society for Animal Cell Technology (ESACT) held the 4th Drug Development Course in Llafranc, Spain. IMTTS lab members Hannah Jill Hunkler, Stevan Stojanovic and Jan Fiedler participated in this 3-days course getting detailed insight on screening technologies and validation setups to develop novel therapeutics. Interestingly both academic and industrial views were combined in a very fruitful manner.

International participants of 4th ESACT Drug Discovery Course in Llafranc/Spain/Catalunya. Copyright ESACT.


June 2019, IMTTS researchers Ankita Garg, Cheng-Kai Huang, Hannah Hunkler, Fabian Kreutzer and Stevan Stojanovic presented their work at the Basic Science Summer School, organized by the Council on Basic Science of the European Society of Cardiology (ESC), at Sophia-Antipolis (France). This biennial course gives a broad overview of the cardiovascular research from basic concepts to the translation by experts of the field, including lectures about building and developing a career in science. Attendance was supported by “Joachim Herz Stiftung Add-on Fellowship for Interdisciplinary Sciences” (Ankita Garg), “Die Gesellschaft der Freunde der MHH e. V.” (Hannah Hunkler), and the “ESC Working Group on Cellular Biology of the Heart” (Fabian Kreutzer).

October 2019, The Clinical Research Group KFO311 was positively evaluated by the DFG and will be funded for another 3 years

The clinical Research Group KFO311 on “Advanced cardiac and pulmonary failure: mechanical unloading and repair” will be funded for a second 3-years funding period. The consortium brings together outstanding scientific and clinical expertise of the participating MHH Departments and Institutes. The overarching aim is to explore the effects of mechanical unloading on local and systemic pathomechanisms in advanced cardiac and pulmonary failure and to improve current and/or develop novel therapeutic strategies. Early translational approach will be evaluated in preclinical and clinical trials. Within the first funding period the IMTTS successfully investigated the long non-coding RNA H19 during unloading and repair of dysfunctional myocardial tissue in mice. In close collaboration with PD Dr. S. Cebotari (Co-PI together with Prof. Thum in KFO311 Project 9) a pig model for cardiac unloading was developed as an valuable large animal model towards clinical translation. Based on our findings in a cardiac hypertrophy mouse model, this pig model will be employed in the second funding period to test inhibition of the long non-coding RNA Meg3 as anti-fibrotic treatment during cardiac hypertrophy and unloading. The DFG funds our subproject with EUR 444,600.

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