© Dr. N. Hensel, Neuroanatomie und Zellbiologie, MHH

Curriculum Vitae



Diploma Biochemistry, Leibnitz - University Hannover, Germany



PhD studies, Center of Systems Neurosciences, Institut of Neuroanatomy,

Hannover Medical School, Hannover, Germany


Postdoctoral research fellow, Niedersachsen Network on Neuroinfectiology (N-RENNT),

Institute of Neuroanatomy, Hannover Medical School, Hannover, Germany

2016- 2018

Postdoctoral research fellow, SMA Europe, Institute of Neuroanatomy and Cell Biology, Hannover Medical School, Hannover, Germany

Since March 2018

Senior Researcher, Institute of Neuroanatomy and Cell Biology, Hannover Medical School, Hannover, Germany


Hensel N.*, Verena Raker V.*, Förthmann B., Detering N. T., Kubinski S., Buch A., Katzilieris-Petras G., Spanier S., Gudi V., Wagenknecht S., Kopfnagel V., Werfel T. A., Stangel M., Beineke A., Kalinke U., Paludan S. R., Sodeik B., and Claus P. (2019): HSV-1 triggers paracrine fibroblast growth factor response from cortical brain cells via immediate-early protein ICP0. Journal of Neuroinflammation, in press. *contributed equally.

Walter L. M., Franz P., Lindner R., Tsiavaliaris G., Hensel N.*, Claus P.* (2019): Profilin2a-phosphorylation as a regulatory mechanism for actin dynamics. FASEB Journal, in press. *contributed equally.

Hensel N., Detering N. T., Walter L., and Claus P. (2019): Resolution of pathogenic R-loops rescues motoneuron degeneration in Spinal Muscular Atrophy. Brain, in press.

Bora G., Sucularli C., Hensel N., Claus P., Yurter H. E. (2019): Investigations of Microtubule-associated Protein 2 Gene Expression in Spinal Muscular Atrophy. J. Pediatr. Res. 6, 148-154.

Uhde A.K., Ciurkiewicz M., Herder V., Khan M.A., Hensel N., Claus P., Beckstette M., Teich R., Floess S., Baumgärtner W., Jung K., Huehn J., Beineke A. (2018) Intact interleukin-10 receptor signaling protects from hippocampal damage elicited by experimental neurotropic virus infection of SJL mice. Sci Rep., 8(1)

Hensel, N., Baskal, S., Walter, L. M., Brinkmann, H., Gernert, M., and Claus, P. (2017) ERK and ROCK functionally interact in a signaling network that is compensationally upregulated in Spinal Muscular Atrophy. Neurobiol Dis 108, 352-361

Rademacher, S., Verheijen, B. M., Hensel, N., Peters, M., Bora, G., Brandes, G., Vieira de Sa, R., Heidrich, N., Fischer, S., Brinkmann, H., van der Pol, W. L., Wirth, B., Pasterkamp, R. J., and Claus, P. (2017) Metalloprotease-mediated cleavage of PlexinD1 and its sequestration to actin rods in the motoneuron disease spinal muscular atrophy (SMA). Hum Mol Genet 26, 3946-3959

Hensel, N., and Claus, P. (2017) The Actin Cytoskeleton in SMA and ALS: How Does It Contribute to Motoneuron Degeneration? Neuroscientist, 1073858417705059

Stanslowsky,N., Reinhardt, P., Glass, H., Kalmbach, N., Naujock, M., Hensel, N., Lubben, V., Pal, A., Venneri, A., Lupo, F., De Franceschi, L., Claus, P., Sterneckert, J., Storch, A., Hermann, A., and Wegner, F. (2016) Neuronal Dysfunction in iPSC-Derived Medium Spiny Neurons from Chorea-Acanthocytosis Patients Is Reversed by Src Kinase Inhibition and F-Actin Stabilization. J Neurosci 36, 12027-12043

Hensel, N., Schon, A., Konen, T., Lubben, V., Forthmann, B., Baron, O., Grothe, C., Leifheit-Nestler, M., Claus, P., and Haffner, D. (2016) Fibroblast growth factor 23 signaling in hippocampal cells: impact on neuronal morphology and synaptic density. J Neurochem 137, 756-769

Hensel, N., Rademacher, S., and Claus, P. (2015) Chatting with the neighbors: crosstalk between Rho-kinase (ROCK) and other signaling pathways for treatment of neurological disorders. Front Neurosci 9, 198

Hensel, N., Stockbrügger, I., Rademacher, S., Broughton, N., Brinkmann, H., Grothe, C., and Claus, P. (2014) Bilateral crosstalk of rho- and extracellular-signal-regulated-kinase (ERK) pathways is confined to an unidirectional mode in spinal muscular atrophy (SMA). Cell Signal 26, 540-548

Sun, H., Benardais, K., Stanslowsky, N., Thau-Habermann, N., Hensel, N., Huang, D., Claus, P., Dengler, R., Stangel, M., and Petri, S. (2013) Therapeutic potential of mesenchymal stromal cells and MSC conditioned medium in Amyotrophic Lateral Sclerosis (ALS)--in vitro evidence from primary motor neuron cultures, NSC-34 cells, astrocytes and microglia. PLoS One 8, e72926

Hensel, N., Ratzka, A., Brinkmann, H., Klimaschewski, L., Grothe, C., and Claus, P. (2012) Analysis of the fibroblast growth factor system reveals alterations in a mouse model of spinal muscular atrophy. PLoS One 7, e31202

Nolle, A., Zeug, A., van Bergeijk, J., Tonges, L., Gerhard, R., Brinkmann, H., Al Rayes, S., Hensel, N., Schill, Y., Apkhazava, D., Jablonka, S., O'Mer, J., Srivastav, R. K., Baasner, A., Lingor, P., Wirth, B., Ponimaskin, E., Niedenthal, R., Grothe, C., and Claus, P. (2011) The spinal muscular atrophy disease protein SMN is linked to the Rho-kinase pathway via profilin. Hum Mol Genet 20, 4865-4878 



Dr. rer. nat. Niko Hensel
Institute of Neuroanatomy and Cell Biology,
OE 4140
Hannover Medical School
Carl-Neuberg-Str. 1
30625 Hannover
E-mail: hensel.niko@mh-hannover.de
Phone: +49-(0)511-532-2932
Fax: +49-(0)511-532-2880