Interleukin-1 and Inflammation

Nanda, S.K., Nagamori, T., Windheim, M., Amu, S., Aviello, G., Patterson-Kane, J., Arthur, J.S.C., Ley, S.C., Fallon, P., Cohen, P. (2018) ABIN2 Function is required to suppress DSS-induced colitis by a Tpl2-independent mechanism. Journal of Immunology 201: 3373-3382.

Windheim, M. (2016)  Interleukin-1-induced gene expression requires the membrane-raft-dependent internalization of the interleukin-1 receptor. Cellular Signalling 28: 1520-1529.

Windheim, M., and Hansen, B. (2014) Interleukin-1-induced activation of the small GTPase Rac1 depends on receptor internalization and regulates gene expression. Cellular Signalling 26: 49-55.

Hansen, B., Dittrich-Breiholz, O., Kracht, M., and Windheim, M. (2013) Regulation of the NF-kB-dependent gene expression by ligand-induced endocytosis of the interleukin-1 receptor. Cellular Signalling 25: 214-228.

Windheim, M., Peggie, M., and Cohen, P. (2008) Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology. Biochemical Journal 409: 723-729.

Ordureau, A., Smith, H., Windheim, M., Peggie, M., Carrick, E., Morrice, N., Cohen, P. (2008) The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1. Biochemical Journal 409: 43-52

Windheim, M., Stafford, M., Peggie, M., and Cohen, P. (2008) Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase. Molecular and Cellular Biology 28: 1783-1791.

Windheim, M., Lang, C., Peggie, M., Plater, L.A., Cohen, P. (2007) Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide. Biochemical Journal 404: 179-190.

Zhang, M., Windheim, M., Roe, M.S., Peggie, M., Cohen, P., Prodromou, C., Pearl, L.H. (2005) Chaperoned ubiquitylation - Crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex. Molecular Cell 20: 525-538.