create a scientific infrastructure dedicated to the generation of in vivo systems enabling infection studies and long-term antiviral drug evaluation. Thus, the unit recently has merged with the Humanized Mouse [...] UKE to serve as a new competitive technological platform enabling in vitro and in vivo infection studies with human hepatotropic viruses and preclinical evaluation of new therapeutic concepts within the

highly-sensitive and fast techniques to follow chemical, spectroscopic, and mechanical changes. These studies are usually combined with protein engineering and high-resolution structural analyses. The determination [...] of isolated cells, our research program uses the information gained from kinetic and structural studies, to address the role of specific contractile proteins in supporting motile functions and the potential

limited efficacy in only a subset of patients. The role of the immune system in HDV infection has been studied incompletely. We have been able to map CD8+ T-cell epitopes in chronic HDV infection and characterize [...] while T cells with viral eliminating capacities are chronically activated and prone to apoptosis. By studying immune responses in the liver we could demonstrate that the phenotype of CD8+ T cells is influenced

Annual Meeting 2025. With her poster ‘Organotypic in vitro model of the human lung using hiPSCs to study epithelial-macrophage interactions and bacterial infections in the microenvironment of the upper

International Master study programme "Infectious Diseases - One Health (IDOH)" Module: Infectious Diseases and Diagnostics Module coordinators: Prof. Dr. Abel Viejo-Borbolla, Dr. Nishanth Gopala Krishna

ence-microscopy based in vitro assays Molecular modelling Protein structure prediction Cellular studies using patient-derived primary cells and cell lines X-ray crystallography (in collaboration with Prof

tissue. Furthermore, threedimensional cholangiocyte organoids are being established in order to study mechanisms of cholangiocyte injury in hypothermic and/or hypoxic conditions in vitro . Long-term aim

Dr. med. Christian Dopfer is a specialist in pediatrics and adolescent medicine. He studied human medicine at the Eberhard-Karls-University in Tübingen. He completed further training as a specialist at

for a scientific infrastructure focused on the generation of in vivo systems that allow infection studies and long-term evaluation of antiviral drugs. Team Dr. rer. nat. Katrin Splith

motto “How can we improve the benefits of medical research for patients?". The Center for Clinical Studies (ZKS) and the translation infrastructure of the MHH were presented there by Prof. Schindler. To date