prospective recipient’s own endothelial cells. The engineered tissues being produced are tested in large animal models. Vascularized Trachea Replacements At present, there is no suitable material for repairing [...] myocardial patches are being implanted into fibrotic myocardial scar tissue. Both, small and large animal models are used for testing the practicality of this alternative approach.

available at our center (additional techniques can be implemented by mutual agreement): Examples of small animal PET-CT examinations: Serial 3D whole-body examination of glucose metabolism in tumor-bearing mice [...] images. Validation by ex vivo autoradiography / biodistribution measurements . Examples of small animal SPECT-CT examinations: Dopamine receptor SPECT of the basal ganglia (top left), ECG-triggered contrast

airway disease such as asthma, COPD, fibrosis or lung infection are investigated using preclinical animal models (mouse, rat, hamster, monkey) and by using ex vivo models like precision cut lung sclices

hepatocytes by technologies such as gene therapy. Unfortunately, the promising results obtained in animal models could not be successfully transferred into clinical application in man, yet. The aim of our

created an information film in cooperation with the German Biobank Node (GBN) and Biobank Graz. The animated film explains the entire biobanking process in a comprehensible way, starting with patient education

in association with the program Practical Courses: Application of Real-time PCR Basic Laboratory Animal Science Bio Informatics CRISPR/Cas9 gene editing in primary T cells Digital Fluorescence microscopy

brain abnormalities in humans. We found that stress induces muscle degeneration even in wild type animals and accelerates age-dependent muscular dystrophy and that miRNAs are involved in this process. Future

students). Heads the research commission of the MHH (FoKo) Heads the MHH advisory board for the central animal facility, currently represented by Prof. Dr. Reinhold Förster. Cooperation with the Ombudsperson

Hospital Hygiene Institute of Virology Institute of Immunology Institute for Laboratory Animal Science and Central Animal Laboratory Institute of Molecular Biology Institute for Transfusion Medicine Institute

Miniature hearts for research Replacing animal experiments: an MHH research team has succeeded in producing a haematopoietic heart organoid for the first time. Robert Zweigerdt, Miriana Dardano, Lika Drakhlis [...] also suitable for testing pharmacological agents. ‘In some cases, this works even better than in animal models, for example, because these are subject to other biological influences and the results can