utilizing hiPSC derived ECs in a SuNx PAH Rat model and development of an organ specific BMPR2 KO animal model in rats Major goal is to finally establish the new, innovative therapy concept, based on the [...] detected in 70% of the patients with familial PAH, will be addressed in a clinically more relevant animal model. Thus, a novel BMPR2 knock out (KO) rat model will be developed for evaluation of the cell [...] translate these results to human ex-vivo models and to the porcine TAC model as a clinically relevant animal model, to study the in vivo effects of a lncRNA therapy during cardiac unloading. For example, e
Models of ischemia-/reperfusion induced cholangiopathy in small and large animal models In this project, the workgroup aims to establish and characterize experimental models of ischemia-/reperfusion induced
airway disease such as asthma, COPD, fibrosis or lung infection are investigated using preclinical animal models (mouse, rat, hamster, monkey) and by using ex vivo models like precision cut lung sclices
created an information film in cooperation with the German Biobank Node (GBN) and Biobank Graz. The animated film explains the entire biobanking process in a comprehensible way, starting with patient education
hepatocytes by technologies such as gene therapy. Unfortunately, the promising results obtained in animal models could not be successfully transferred into clinical application in man, yet. The aim of our
detection of e.g. botulinum neurotoxins in an animal test replacement method for botulism diagnostics. In addition, the Rummel lab successfully operates an animal experiment replacement method for BoNT diagnostics [...] Rongsheng Jin at University of California Irvine Research The phrenic nerve hemidiaphragm assay, an animal experiment replacement method for BoNT diagnostics [3] The group leader Dr. Andreas Rumme l has been
Hospital Hygiene Institute of Virology Institute of Immunology Institute for Laboratory Animal Science and Central Animal Laboratory Institute of Molecular Biology Institute for Transfusion Medicine Institute
in association with the program Practical Courses: Application of Real-time PCR Basic Laboratory Animal Science Bio Informatics CRISPR/Cas9 gene editing in primary T cells Digital Fluorescence microscopy
Miniature hearts for research Replacing animal experiments: an MHH research team has succeeded in producing a haematopoietic heart organoid for the first time. Robert Zweigerdt, Miriana Dardano, Lika Drakhlis [...] also suitable for testing pharmacological agents. ‘In some cases, this works even better than in animal models, for example, because these are subject to other biological influences and the results can
patients with CF. Complementary to standard antimicrobial chemotherapy, we are exploring options in animal models to prevent lower respiratory tract infections via local transfer of macrophages, CFTR gene [...] Pseudomonas Genomics Pseudomonas aeruginosa lives in soil, fresh and salt water and colonizes plant and animal surfaces. In humans, P. aeruginosa has become one of the most common bacterial pathogens of local