from the human heart, especially concerning the beating rate. Compared to the human heart, the beating frequency is about 5-8 times higher in the rodent model. Thus, a functional integration of human CMs into [...] first time, the formation and functional coupling of large contractile human stem cell-derived heart muscle islands in a non-human primate (pig-tailed macaque, Macaca nemestrina) model of MI (Chong, J.J [...] clinicians, veterinarians and experts from the German Primate Center, we will transplant human iPSC-based CMs into non-human primates (crab eating macaque or cynomolgus monkey; Macaca fascicularis) in order to

life-threatening atypical pneumonia in humans and is usually transmitted via inhaled water droplets. To sustain its intracellular lifestyle in amoebae as well as in human cells, L. pneumophila injects more [...] of Borrelia burgdorferi Borrelia are gram-negative screw-like bacteria that can be transmitted to humans through the bite of hard-bodies ticks. The species Borrelia burgdorferi , B. afzelii , B. garinii [...] adhesins play essential roles in initiation and/or maintenance of infection. For ~ 30 adhesins, a human ligand has been identified through in vitro binding assays, whereas for only a small fraction an in

127-146. Katzer M: Challenges to Liberal Human Rights. In: Simon Bennett / Éadaoin O’Brien (eds.): What Future for Human Rights in a Non-Western World? Human Rights Consortium, School of Advanced Study [...] Frankfurt am Main in 2012 with a thesis on the theory of human rights. Research interests: Didactics of medical ethics Clinical research ethics Theory of human rights Current research project: Ethical attitudes [...] requirements for human challenge studies: a systematic review of reasons. Clinical Pharmacology & Therapeutics 114 (2023), S. 1209-1219. doi: 10.1002/cpt.3054 Katzer M: Rawls's List of Human Rights and Se

Infrastructure: Primary Human Hepatocyte (MHH) / Humanized Mouse (UKE) Core Facility Infrastructure coordinator: Florian Vondran Located at Hannover Medical School (MHH), the Primary Human Hepatocyte (PHH) Core [...] merged with the Humanized Mouse Platform lead by Prof. M. Dandri at UKE to serve as a new competitive technological platform enabling in vitro and in vivo infection studies with human hepatotropic viruses [...] groups within the German Centre for Infection Research (DZIF) with hepatocytes freshly prepared from human liver tissue. The isolation of PHH is a standardized, technically complex procedure and PHH are only

Department of Human Genetics All information on genetic counseling, diagnostics, research, education, and our team can be found here. Welcome to the Department of Human Genetics Prof. Dr. Nataliya Di Donato [...] Donato, Director Department of Human Genetics In the Department of Human Genetics, we combine outstanding application-focused research with professional patient care. Our international and interdisciplinary

composition of sarcomeric proteins. Subcellular myofibrils can be obtained from human (e.g., biopsies), human-derived and non-human cardiac and skeletal small muscle samples (e.g., mouse, rat, rabbit, zebrafish [...] Contraction-relaxation function and mechano-chemical coupling of myofibrils Investigations of human, human pluripotent stem cell-derived cardiomyocytes and animal contractile models in non-pathologic and [...] zebrafish and hESC-/hiPSC-CMs). In vitro -differentiated cardiomyocytes . Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) hold great potential for the treatment of cardiovascular diseases by cell

organoid for the first time. Robert Zweigerdt, Miriana Dardano, Lika Drakhlis (from left) How do human organs develop and what happens to them when they become diseased? To answer these questions, researchers [...] producing a heart-forming organoid (HFO) and reproducing the entire path to the early stage of a human heart in cell culture. One unsolved problem in science to date has been the development of a model [...] that simulates heart development and haematopoiesis in combination. Haematopoiesis begins in the human embryo after the fourth week in the aorta, close in time and location to the cardiac anlage. Building

Impact Neuronal Structure and Function in the Adult Human Brain New Study Reveals How Clinical Factors Impact Neuronal Structure and Function in the Adult Human Brain Researchers at Hannover Medical School have [...] medical treatments affect the structure and function of superficial pyramidal neurons in the adult human neocortex. The study, led by Maximilian Lenz, Pia Kruse, Amelie Eichler, and colleagues, provides [...] individual clinical factors—such as age and medication—when examining neuronal properties in the human brain. By illuminating how aging and medical treatments influence brain plasticity, the study paves

Isolation, Culture and Cryopreservation of Primary Human Hepatocytes Large quantities of primary human hepatocytes (PHH) are required for basic research and clinical applications. In addition, they represent [...] project is to evaluate alternative sources of liver tissue for the isolation of high quality primary human hepatocytes. Furthermore, we are interested in innovative concepts for long-term cell culture and

Primary Human Hepatocyte Core Facility The Primary Human Hepatocyte (PHH) Core Facility at the Hannover Medical School (MHH) provides research groups with freshly isolated hepatocytes from human liver tissue