is impaired. Unlike in some amphibians and fish species, such damage is not repaired in an adult human heart. Scientists around the world are therefore working on strategies to replace destroyed heart [...] laboratory from "reprogrammed" body cells of adults and can then give rise to any cell type of the human body - including heart muscle cells. In addition to producing such cardiomyocytes from iPS cells in [...] e aggregates are now to be refined in such a way that they can also be used for heart therapy in humans. Suicide gene to prevent tumour formation This goal presents the HEAL team with very special challenges

groups that have to be taken into account in a transfusion. Tissue characteristics, the so-called human leukocyte antigens (HLA), also play a role. These molecules on the surface of body cells are comparable [...] Megakaryocyte cells produce platelets in a mouse model "We obtain the iPSCs from reprogrammed cells of a human with blood group zero, which is an ideal donor group that does not carry AB0 antigens and is therefore [...] " says Professor Figueiredo. The scientist is convinced that this should be equally successful in humans. "A living body is always the best bioreactor." There is no danger of the donor cells degenerating

study in humans The combination has already been shown to work in human AML cell cultures and in mouse models. Now the efficacy, safety and tolerability of the new therapy are to be tested in a human clinical

gamma-delta T cells in cord blood samples as well as from adult blood samples. "Interestingly, certain human Vγ9Vδ2 T cells are generated exclusively in the very early phase of life to be ready for immediate [...] immediate use at the time of birth and afterwards to persist as innate immune cells throughout life in humans," reports Dr Fichtner. Only recently, the team was able to show that certain gamma-delta T cells p [...] about RESIST can be found at www.RESIST-cluster.de SERVICE: The original publication "A fetal wave of human type 3 effector γδ cells with restricted TCR diversity persists into adulthood" can be found here

are using heart muscle cells from human induced pluripotent stem cells. These are "reprogrammed" body cells from adults that can give rise to any cell type in the human body - including heart muscle cells [...] platform with which a COVID course can be generated that is similar and thus comparable to that of humans. The results should then explain in more detail which mechanisms the corona virus uses to weaken

library among more than one million AAV variants, which function both in mouse liver cells and in human liver cells. "This cross-species application possibility is very important for the development of [...] necessary preclinical trials in the mouse model and their transfer to the later clinical trials in humans," explains the molecular biotechnologist. AAV vector variants already successful in mice against [...] have to be confirmed in further studies in large animal models and later also in clinical studies in humans. More than 400 monogenetic diseases are known for the liver. So there could be many more transport

"We had several winners in the running and then tested how strongly they were intercepted by the human immune system." Not all gene taxis reach their target Not all vectors that target specific body cells [...] therefore had to prove how well they could escape the neutralising antibodies in cell culture with human blood plasma. The two AAV variants also survived this test. They were then loaded with a biomolecule [...] have to be confirmed in further studies in large animal models and later also in clinical studies in humans. SERVICE: For further information, please contact Dr. Christian Bär, baer.christian@mh-hannover.de

affected by the virus. The efficacy of the drug is being tested on human lung tissue sections as well as in 3-D cell cultures from human lung epithelium. "If all this works, we will be able to use our iGUARD [...] 08.12.2021 Viruses are a major problem for human health worldwide - and not just since the outbreak of the SARS-CoV2 pandemic. Despite successful vaccine development, there are still no effective drugs

organ nevertheless remains as small and effective as possible, as is the case with the human lung. In the human lung, about 100 to 140 square meters of breathing surface are packed into 300 million alveoli [...] believes that it will be several years before the artificial lungs can be transplanted into the human body. The DFG Priority Program SPP 2014 is funding a total of ten projects throughout Germany. The

well-educated engineers, scientists, and clinicians To advance regenerative medicine to repair the human body following injury or disease, there is a critical need for well-educated engineers, scientists [...] , and clinicians to work jointly to translate applied research to clinical treatments to improve human health. “MHH has built a unique environment to bring all these facets together. In particular knowledge