seriously ill children be improved by rapid genetic diagnosis? This question is being investigated by a team from Pediatrics and Human Genetics at Hannover Medical School (MHH) in the "Baby Lion" study. The [...] rare after all," says Dr. Bernd Auber of the Institute of Human Genetics. For the study, he and his team are focusing on a special patient group: children in their first weeks and -months of life who are [...] Suffering paths can be shortened and unnecessary therapies and examinations can be avoided. Dr. Auber's team now wants to find out whether these findings can also be transferred to the German healthcare system

for drugs." Chemotherapy damages the heart In the REVERSE project, Professor Thum and his research team will first look for circRNAs that control the cardiac remodelling process. This side effect on the [...] selected RNA structures actually control the cardiac remodelling in each case. To do this, the research team uses the method of "living heart slices". These are wafer-thin slices of damaged heart muscle tissue [...] our circRNA candidates in the living heart slices," says the scientist. In a next step, the research team then wants to investigate how they can stop the two different forms of cardiotoxicity. In this way

receiving a further 2.5 million euros for the further development of new antiviral agents. The research team led by Professor Dr Dr Axel Schambach, Head of the Institute of Experimental Haematology at Hannover [...] against emerging infectious diseases. Targeted blocking of virus replication The iGUARD research team is focussing on the parainfluenza virus, which primarily affects the lower respiratory tract in children [...] viruses, so to speak. With the help of artificial intelligence, so-called in-silico design, the research team searched gene databases primarily for "conserved" regions. These are essential for the virus and are

ion between neurones is disrupted. Treatment options are limited and there is no cure. A research team from the Institute of Clinical Biochemistry at Hannover Medical School (MHH) has discovered that the [...] different lengths. Until now, it was unclear whether these also have different functions. The research team is focussing on the short-chain polymers, for which it has been shown that they play an important [...] junctions." The consequences are forgetfulness and dementia. In preliminary studies, the research team was already able to show in a mouse model of Alzheimer's disease that short-chain PolySia of a very

Hannover region to use this new treatment method. The procedure is implemented by an interdisciplinary team from the Clinic for Cardiac, Thoracic, Transplantation and Vascular Surgery, the Clinic for Cardiology [...] the transapical approach. "Transapical" means "via the tip of the heart". The interdisciplinary MHH team works with the artificial Tendyne valve from Abbott, which simulates and plans each intervention in [...] Angiology. Many disciplines and professions involved The operation has to be very well prepared by the team, but it only takes about two hours for the patient in the operating theatre. One day in the intensive

president of the MHH, who is responsible for business management and administration. "It takes a dedicated team of educators to spark curiosity in preschool children and encourage them to ask questions. At Campus [...] Campus Children, everyone obviously enjoys this, and recognition through the certificate rewards the team's efforts," Martina Saurin emphasized. Offerings are integrated into the daycare center's daily routine

managers from the job center support the participants throughout the entire period.In addition, the MHH team conducts extensive research into the reintegration process of unemployed people with mental illness [...] nationwide," says Dr. Ivo Heitland, psychological psychotherapist and head of the medical-psychological team. OnkoriskNET: Care close to home and telemedical advice If there is a suspicion of a hereditary cancer [...] human genetic care, especially in rural areas.The innovation fund project "OnkoRiskNET", led by a team from the MHH Institute of Human Genetics, has tackled this problem and set up a cooperation network

supplied with blood and thus oxygen and the organ is irrevocably damaged. An international research team led by Dr. Robert Zweigerdt, cell biologist at the Leibniz Research Laboratories for Biotechnology [...] treat tissue damage on the organ surface. New strategy with small cell clusters The HEAL research team is therefore pursuing a new strategy. "Although we also rely on iPS cardiomyocytes, we want to grow [...] for heart therapy in humans. Suicide gene to prevent tumour formation This goal presents the HEAL team with very special challenges. On the one hand, the iPS cells must be adapted in such a way that the

disrupts the regulation of iron absorption via the mucous membrane of the small intestine. A research team led by Professor Dr. Michael Ott and Dr. Simon Krooss from the Department of Gastroenterology, Hepatology [...] strand," explains Dr Krooss. Mouse model: iron levels in the blood drop significantly The research team investigated this biotechnological trick in the mouse model. With a single injection, the rate of [...] is sluggish, so it takes time for more liver cells to make the gene correction." But the research team wants more. So far, they have packaged the CRISPR/Cas system with the molecular tool in a so-called

the Department of Paediatric Haematology and Oncology at Hannover Medical School (MHH), the research team analysed factors that influence the cancer risk within the Li-Fraumeni spectrum. In the process, the [...] Penkert from the Institute of Human Genetics, who is currently conducting research in Professor Kratz's team. A total of 141 people from 94 families with disease-causing TP53 variants were analysed. "73 families