amount of genetic material. If everything works, the gene therapy will be tested in clinical trials on humans at the end of the project. Professor Schambach is certain that the procedure has great potential [...] project is a cooperation between the MHH Institute of Experimental Haematology, the MHH Institute of Human Genetics, the Hearing4All Cluster of Excellence, the University Medical Center of the University of

The aorta is the largest blood vessel in the human body. It originates in the heart and carries oxygen-rich blood to all parts of the body. The most common disease of the aorta that requires treatment [...] by it reflexively. The silk is extremely thin and tear-resistant and completely degradable in the human body. Using a special apparatus that assistant physician Dr Helms constructed himself, the thread

"We have successfully tested the efficacy of our RNAi candidates on human lung tissue sections as well as in 3D cell cultures from human lung epithelium," explains Professor Dr. Armin Braun, Head of Preclinical

treated for six months a total of five times with mesenchymal stem cell products obtained from a human umbilical cord. "The treatment led to a significant improvement in growth, exercise tolerance and [...] stem cell therapy is based on cells from the umbilical cord of newborns and is also called HUCMSC (human umbilical cord mesenchymal stem cell). The researchers' analyses showed that the products of these

Korf-Klingebiel, biologist and first author of the study. Whether all of this is also significant for humans was investigated by the team in patients with heart failure due to aortic stenosis. In this disease [...] laboratory, the MYGDF level dropped to normal. Pressure overload thus also leads to MYDGF release in humans. The work shows that the positive aspects of inflammation must be considered when thinking about

successfully tested the efficacy and safety of our RNAi candidates on human lung tissue slices and in 3D cell cultures from human lung epithelium and animal models," explains Professor Dr Armin Braun,

27.10.2021 Cervical cancer is one of the most common diseases of the female reproductive organs. Human papilloma viruses, HPV for short, are almost always responsible for cervical cancer and the corresponding [...] once a year, the so-called Pap test, to detect cell changes. From the age of 35, they are tested for human papilloma viruses every three years in combination with the Pap smear. The problem: 30 per cent of

Status: 11 February 2021 On average, a human being consists of about 30 trillion body cells - and just as many bacteria. Without them, we would not be able to live. Not only in the intestine, on our skin [...] the renowned journal Biofilms and Microbiomes. Microorganisms form a community "Until recently, the human lower respiratory tract was considered sterile," explains Professor Tümmler. Therefore, most studies

developed standard procedures for the isolation, activation and propagation of T and NK cells of the human immune system, which we make available to researchers at the MHH as well as to external companies [...] types and capture it in a time-lapse video. A look into the microscope, for example, shows whether human T cells such as CARs and TRUCKs, which have been genetically modified in the laboratory, actually

they communicate with cells of the acquired immune system in the HCC tumor. To do this, samples of human tumor tissue are compared with healthy liver tissue and analyzed to determine which immune cells are [...] response. If the therapeutic approaches work in the mouse model, they could then be tested in a human clinical trial. "This is an ambitious four-year program," Dr. Heinrich admits. "However, we hope to