organoid for the first time. Robert Zweigerdt, Miriana Dardano, Lika Drakhlis (from left) How do human organs develop and what happens to them when they become diseased? To answer these questions, researchers [...] therapy for regenerating damaged hearts. HEAL Project Page TACTiC Preclinical evaluation in a non-human primate model and a roadmap for clinical application The Federal Ministry of Education and Research [...] system. With the help of induced pluripotent stem cells (iPS cells) from genetically reprogrammed human tissue cells, heart muscle cells can be produced. These should form the basic building block for a

animals to humans and have caused two epidemics including the current COVID-19 pandemic. The treatment options against these viruses are very limited. The ways corona viruses are transmitted to humans as well [...] status in addition to results from serology testing for antibodies against SARS-CoV-2. Development of human neutralizing monoclonal antibodies against SARS-CoV-2 Project leader: Prof. Dr. med. Thomas F. Schulz [...] Department / Institute: Institute of Virology We want to generate broadly neutralizing, i.e. protective, human monoclonal antibodies as recombinant proteins for a future antiviral treatment in the early phases

semester, Modul BCM P 04) Lab internships and Master thesis (scheduled individually) Medicine („Human- und Zahnmedizin“): Seminars in Biochemistry /Molecular Biology („Nukleinsäuren 1&2“) Practical course

interaction of Pseudomonas aeruginosa and the human host microenvironment in development of persistent infection in the lower respiratory tract of humans Supervisor: Prof. Dr. Susanne Häußler, Institute [...] University, La Paz, Bolivia Miriam Nörder Research Topic: Development of mice containing the human immune system and/or human liver for the preclinical validation of vaccine candidates Supervisor: Prof. Dr. Carlos [...] University of Delhi South Campus, India Rita Haller Research Topic: Staphylococcal manipulation of human cell signaling systems Supervisor: Dr. Volker Winstel, Pathogenesis of Bacterial Infections, Twincore

Fedorov, R., Henn, A., Taft, M. H. #, and Manstein, D. J.# (2020) Mechanochemical properties of human myosin 1C are modulated by isoform-specific differences in the N-terminal extension. J Biol Chem. [...] and Gunning, P. W. (2018) Co-polymers of Actin and Tropomyosin Account for a Major Fraction of the Human Actin Cytoskeleton. Curr. Biol. 28, 2331-2337.e5. doi: 10.1016/j.cub.2018.05.053. Latham, S. L., Ehmke [...] A. O., Taft, M. H. , Manstein, D. J., and Henn, A. (2017) N-terminal splicing extensions of the human MYO1C gene fine-tune the kinetics of the three full-length myosin IC isoforms. J. Biol. Chem. pii:

medicine. Genomics is an important cornerstone for this. PD Dr. Anke Katharina Bergmann, Institute of Human Genetics and scientist at the Comprehensive Cancer Center (CCC) of the Hannover Medical School (MHH) [...] is on the evaluation of telemedicine genetic counseling strategies in order to improve access to human genetic counseling. Particularly in rural areas, there is a lack of comprehensive access. Personalised

on the other hand, reduced fibrosis formation. "We were also able to detect the P2Y14 receptor in human hepatic stellate cells using special antibodies," says the hepatologist. The connection between cell [...] the liver tissue and fibrosis formation has also been confirmed in studies of healthy and diseased human livers. The discovery could be an important step towards an anti-fibrotic therapy. The next step is

Toxicology and Experimental Medicine ( ITEM ), Hannover Project: Air-Liquid Interface cultures of human primary distal respiratory epithelial for in vitro modelling of SARS-CoV2 infections To investigate [...] project we will first establish methods for isolating and expanding distal epithelial cells from human lung explants and differentiate these into AT1 cells in air-liquid interface cultures that can serve

group at the HZI. Mouse models reflect the human disease pattern "Tumour development in the preclinical mouse models we have established is similar to that in humans," says Dr Tetyana Yevsa. "Therefore, mouse

pigs, among others. Because the viruses have zoonotic potential, they can also be transmitted to humans and cause liver inflammation. In Germany alone, up to 420.000 people become infected with genetically [...] we want to use a special gene scissor that only cuts the viral RNA genetic information, but leaves human RNA intact, which acts as a construction manual for certain proteins to convert the information of