e Systems" research network led by Professor Dr. André Bleich, Director of the Institute of Laboratory Animal Science at Hannover Medical School (MHH), and Professor Dr. Maren von Köckritz-Blickwede from [...] experiments has been constant for years, while they are declining in other research areas," explains Professor Bleich. However, interdisciplinary collaboration has already enabled various alternative models [...] oxygen conditions in the intestine are different from those in the lung tissue in the breath," says Professor von Köckritz-Blickwede. "It's important that we can perform the studies under realistic conditions

diseases. However, little is known about the molecular biological causes. A research team led by Professor Dr. Christian Bär from the Institute of Molecular and Translational Therapy Strategies of the Hannover [...] ability to divide completely. “Telomer lengths are therefore biological markers of age,” explains Professor Bär. Chimeric mouse models with different organ and immune ages The research team will first investigate [...] but also to examine the influence of telomere shortening and telomere damage in detail,” says Professor Bär. Gene therapy could improve organ regeneration The studies are also intended to lay the foundation

children and adults from hereditary deafness with the help of gene therapy is one of the goals of Professor Dr. Dr. Axel Schambach, head of the Institute for Experimental Haematology at Hannover Medical School [...] a loss of vision and balance. Responsible for this is a mutation in a gene called MYO7A, which Professor Schambach and his team are focusing on. If a person inherits the damaged gene from both father and [...] . "Since MYO7A is a very large gene, we need a gene taxi with a large boot, so to speak," says Professor Schambach. The research team therefore uses lentiviral vectors (LV), which can carry a large amount

cells also exist in the human lung remained controversial in science. Now, a research team led by Professor Dr. Christian Mühlfeld, acting head of the Institute of Functional and Applied Anatomy at the Hannover [...] rats, it was found that this cell type influences several important functions in the lungs," says Professor Mühlfeld. For example, the cell plays an important role as a vitamin A store in the development [...] tissue sections from healthy, fibrotic or damaged (emphysematous) human lung tissue provided by Professor Dr. Danny Jonigk's team from the MHH-Institute of Pathology. Dr. Julia Schipke used various markers

bacterial proliferation and the development of cancer. Advancing inflammation research In his research, Professor Garbers is primarily concerned with the role of cytokines in chronic inflammatory diseases. "Actually [...] all, but on the contrary are involved in the permanent maintenance of the inflammatory reaction." Professor Garbers wants to prevent this overreaction and is investigating on a molecular level how cytokines [...] as well. The biochemist and licensed pharmacist takes over the Institute from his predecessor, Professor Dr. Rita Gerardy-Schahn, with a research focus on glycobiochemistry and diabetology. Together with

11.05.2023 How do human cells defend themselves against adenoviruses? The team of RESIST Professor Dr. Sabrina Schreiner from the Institute of Virology at the Hannover Medical School (MHH) has come a good [...] and Dr Christina Weiß from the Institute of Virology at the Technical University of Munich from Professor Schreiner's research group there. The team of authors also includes Dr Samuel Hofmann from the MHH [...] example. They can also die from such an infection. Cells defend themselves with the protein Apobec3A Professor Schreiner's team has now found that human cells defend themselves against adenovirus infection with

heart muscle because connective tissue cells are deposited, the so-called fibrosis. For years, Professor Dr. Dr. Thomas Thum, head of the Institute for Molecular and Translational Therapy Strategies at [...] and fill the heart chambers with enough blood. So far, this cardiac fibrosis is hardly treatable. Professor Thum and his research team are focusing on so-called long non-coding RNAs (lncRNA). These are building [...] Meg3 inhibitor in animal models for efficacy safety in order to reach clinical maturity," explains Professor Thum. For this phase of drug development, it is usually very difficult to get the necessary financial

" emphasises Professor Kratz, who, besides others, was in involved in the development of the Li-Fraumeni spectrum classification. SERVICE: For further information , please contact Professor Dr. Christian [...] for the first time using data from the German Cancer Predisposition Registry. In the study led by Professor Dr. Christian Kratz, Director of the Department of Paediatric Haematology and Oncology at Hannover [...] prediction," says Penkert from the Institute of Human Genetics, who is currently conducting research in Professor Kratz's team. A total of 141 people from 94 families with disease-causing TP53 variants were analysed

employer for the brightest minds," emphasises MHH President Professor Dr. Michael P. Manns. SERVICE: For further information, please contact Professor Dr. Dr. Anette Melk, melk.anette@mh-hannover.de or visit [...] scientific training, the content of which is precisely tailored to the individual participants," says Professor Dr. Dr. Anette Melk, spokesperson for the programme. The three-year funding period is professionally [...] career in academic medicine, but at the same time increases the quality of patient care," explains Professor Melk. The programme builds on successful career programmes for clinician scientists developed at

School (MHH) are now using a new treatment procedure for severe heart attacks. The team led by Professor Dr. Andreas Schäfer, Head of Cardiovascular Intensive Care Medicine, is using - for the first time [...] survive it develop severe heart failure due to the large scarring of the heart muscle," explains Professor Schäfer. These patients can benefit from SSO2 therapy. It is used in the event of an acute heart [...] muscles were only minor, and the pumping capacity of the heart showed no relevant limitations," says Professor Johann Bauersachs, M.D., Director of the Department of Cardiology and Angiology. SSO2 therapy improves