Methods Macromolecular X-ray crystallography State-of-the-art molecular biological and cell biological techniques Heterologous protein expression in prokaryotic and eukaryotic hosts Protein purificati

Methods Our group employs a combinatory approach of biochemistry, biophysics, TIRF imaging with purified proteins, genome editing and cell biology to better understand the molecular basis of a number

Teaching Bachelor of Science Biochemistry: Molecular Biochemistry and Methods (BCB P 15) Master of Science Biochemistry: Instrumental techniques (BCM WP 41) Human Medicine and Dentistry: Biochemistry/

Current Projects Analyses of actin-binding proteins in motility, phagocytosis and regulation of the cell cortex

Alumni Graduate Students Graduate Students Dr. Steve Ludbrook (1993-1996 PhD in the Eccleston and Manstein groups) Director Molecular Pharmacology, Bicycle Therapeutics, Cambridge, England, United Kin

Methods Methods Molecular and Cell Biology: mammalian cell cultures; human oocytes; primary neuronal and glial cells; D. discoideum ; immunohictochemistry; transfection Spectroscopy: Absorption and Fl

Research Interests Actin Myosin Dynamin Tropomyosin Cell motility and cytoskeletal dynamics Intracellular pathogen sensors Protein structure, dynamics, reaction mechanisms, and allostery Small-molecul

Scientific Achievements Total synthesis of FAD and FMN analogues and their application for probing stereo-specificities of flavin cofactors in enzymatic reactions. Pioneering work on the molecular gen

Group Members Dr. rer. nat. Peter Franz Despoina Kyriazi Claudio Salinas Lea Voth Franca Seidensticker Luise Epler Fanny Major Alumni • Dr. rer. nat. Almke Bader • Dr. rer. nat. Ralph Diensthuber • B.

Current Projects Current Projects Enzyme Kinetics and Mechanisms of Energetic Coupling in Motor Proteins Cytoskeleton Dynamics and Motility of Cellular Systems Protein Engineering and Design of Tunabl