This project is part of the MHH-HIB collection

Patient collective:

• Inclusion criteria:
  • patients with chronical primäry Tic disorder (chronical motoric Tic disorder, chronical vocal Tic disorder and Tourette syndrom)
  • each age
  • male and female
• exclusion criteria:
  • secundary Tic disorder
  • vorübergehende Tic disorder

This project is part of the MHH-HIB collection

• In Cooperation with the clinic of Pneumology.

Patient collective:

• Patients with severe bronchial asthma of different origins (allergic or intrinsic).
• Inclusion criteria:
  • Eosinophilie (>300 Eosniophile / ml Blut)
  • Therapieoption anti IL-5 Antibody dose (exhausted conventional therapy (LABA, LAMA, high dosis ICS +/- oral steroid therapy)).

It follows a longitudinal Sampling before and after anti IL-5 antibody therapy.

This project is part of the MHH-HIB collection.

The blood samples are obtained as part of a large-scale cardiomyopathy registry, which is currently being established at the MHH.

The patients should be observed over the years and bio samples should be obtained repeatedly.

Patient collektive:

• Inclusion criteria
  • Dilatative Kardiomyopathie
  • Noncompaction Kardiomyopathie
  • Inflammatorische Kardiomyopathien (Myokarditis)
  • Metabolische Kardiomyopathien
  • Sekundäre Kardiomyopathien (toxische, infiltrative, Speichererkrankungen)
  • Restriktive Kardiomypathien
     

This project is part of the MHH-HIB collection.

Patient collektive:
Patients with rare, congenital, genetically determined metabolic diseases (especially energy metabolism, amino acid metabolism, lysosomal storage diseases, glycogenoses, patients on a ketogenic diet).

This project is part of the MHH-HIB collection.

Patient collektive:

Oncological patients with advanced, castration-refractory prostate carcinoma who are being given new molecular-directed radionuclide therapy (PSMA ligand therapy) (which has already been clinically used at the MHH), which is directed against the prostate-specific membrane antigen (PSMA). These patients are treated every 8 weeks in a standardized manner and, at defined time intervals, extensively characterized by laboratory chemistry, imaging and clinically (every 8-16 weeks).

Blood samples are taken before therapy and in total at least three times after each therapy cycle (each after 8 weeks).

This project is part of the MHH-HIB collection.

Samples from patients with autoimmune hepatitis are collected.

The project is also part of the KFO 250.

This project is part of the MHH-HIB collection.

Patient collective:

Patients with symptomatic heart failure (NYHA II-IV) who are presenting to the cardiology clinic and who are included in the cardiologist use case as part of the HiGHmed consortium project (BMBF).

A precisely defined data set is collected for all patients (clinical data, laboratory data, parameters of technical examinations such as ECG, exercise ECG, echocardiography, hemodynamic data). These data are then analyzed in cross-location medical data integration centers (MeDiC) using medical information technology.

The analyzes carried out in the MeDiC are intended to identify patient collectives with heart failure who are at high risk of hospital admission due to worsening of heart failure.

After identification, these patients are then looked after specifically and the treatment is intensified if necessary (including heart failure nurse, telemedicine, patient app) in order to avoid future hospitalizations due to heart failure and to improve the patient's prognosis.

High-quality bio-samples are used for further scientific investigations in order to identify previously unknown disease mechanisms and to improve patient care.

This project is part of the MHH-HIB collection.

•  Setup of a cardiology endocarditis registries

Since patients from all MHH clinics with suspected endocarditis usually go through the echocardiography laboratory of the Clinic for Cardiology for an echocardiographic diagnosis, patients for this register can be easily identified here. In this register, structured data sets of endocarditis patients (clinic, laboratory, microbiology etc.) are to be collected using the multimodal imaging (echocardiography, leukocyte scintigraphy, PET / CT, inflammation imaging with specific antibody-coupled tracers) by the Clinic for Cardiology & Angiology and Nuclear Medicine become.

 in Planung

Das Projekt ist Teil der MHH-HIB Sammlung.

Patientenkollektiv: Patienten bei denen bei der Strahlentherapie eines Tumorleidens früh (Anfang der Bestrahlungsserie, niedrige Dosis) Nebenwirkungen auftreten.

Einschlusskriterien:

• Definitive Strahlentherapie eines Tumorleidens
• Alter ≥ 18, Einwilligungsfähigkeit
• vollständige Anamnese inkls. Medikation
• früh ausgeprägte radiogene Nebenwirkungen

Ausschlusskriterien:

• palliative Strahlentherapie, nicht kurativ
• monogene Erbkrankheiten
• geplante Strahlendosis nicht erreicht

In Planung

Collection of  plasma and buffy coat of  patients with fibromuscular dysplasia.