Reseach Group Dr. Hans Bakker
Endoplasmic Reticulum Glycosylation
Dr. Hans Bakker
Medizinische Hochschule Hannover, MHH
Institut für Klinische Biochemie, OE 4340
Building J03, Level 04, Room 1290 (Office), Room 1250 (Lab)
C-mannosylated tryptophans in thrombospondin type 1 repeats are part of the tryptophan-arginine ladder that forms the heart of the repeat. The mannoses are transferred by specific endoplasmic reticulum localized C-mannosyltransferases of the DPY-19 family. The name DPY-19 comes from the worm C. elegans, where mutations in the C-mannosyltransferase gene lead to a temperature-sensitive DumPY phenotype.
In humans there are four homologs of DPY-19, which are called DPY19L1, DPY19L2, DPY19L3, and DPY19L4.