Arbeitsgruppe Dr. Hans Bakker
Endoplasmic Reticulum glycosylation
Dr. Hans Bakker
Phone: +49(0)511/532-5214 or -9806
Building J03, Level 04, Room 1290
A thrombospondin type 1 repeat with two C-mannoses linked to tryptophan residues. The tryptophans are part of the tryptophan-arginine ladder that forms the heart of the thrombospondin repeat. The mannoses are transfered by specific endoplasmic reticulum localized C-mannosyltransferases of the DPY-19 family. The name DPY-19 comes from the worm C. elegans, where mutations in the C-mannosyltransferase gene lead to a temperature-sensitive DumPY phenotype.