Arbeitsgruppe Dr. Hans Bakker

Endoplasmic Reticulum glycosylation

Portraitfoto Hans Bakker
Hans Bakker, Copyright: Klinische Biochemie | MHH

 

Dr. Hans Bakker

Ph. D.

Phone: +49(0)511/532-5214 or -9806

FAX: +49(0)511/532-8801

E-Mail: Bakker.Hans@mh-hannover.de

Building J03, Level 04, Room 1290


Research

C-mannosylation

A thrombospondin type 1 repeat with two C-linked mannoses (green), Copyright: Hans Bakker | MHH

- C-mannosylation

A thrombospondin type 1 repeat with two C-mannoses linked to tryptophan residues. The tryptophans are part of the tryptophan-arginine ladder that forms the heart of the thrombospondin repeat. The mannoses are transfered by specific endoplasmic reticulum localized C-mannosyltransferases of the DPY-19 family. The name DPY-19 comes from the worm C. elegans, where mutations in the C-mannosyltransferase gene lead to a temperature-sensitive DumPY phenotype.