Group Shcherbata

Prof. Dr. Halyna Shcherbata

Institute for Cell Biochemistry

Hannover Medical School (MHH)

OE 4310, Carl-Neuberg-Str. 1, 30625 Hannover, Germany

Building J03, Level 01, Room 1320

Phone: +49511532-3384 







Welcome to the Shcherbata group!

In our group we investigate the function of miRNAs in maintenance and differentiation of stem cells under normal conditions, stress or disease in the fruit fly Drosophila.

Our group focusses on the function of miRNAs in the maintenance and differentiation of cells under normal or pathogenic conditions as well as under particular stress. We were able to show that miRNA-controlled regulatory circuits are formed by feedback- or feedforward-controlled signalling pathways. This reduces transcriptional noise and fine-tunes gene expression, ultimately regulating the overall gene expression profile of the cell. miRNAs therefore have important functions in the control of cell division or cell differentiation. If miRNA levels are dysregulated during stress or disease, this therefore severely disrupts tissue regeneration and homeostasis.

In summary, we have found that miRNAs have important functions as

  • Spatio-temporal determinants of cell fate
  • Stabilisers for differentiation processes
  • Elements in the stress response

Our studies show that miRNAs are important channelling factors that confer stability and robustness to errors or random fluctuations in biological systems.