Tianbang Wang
Dr. rer. nat.
Contact
Tel: +49 511 532 -2754 (office), -3654 (lab)
Fax: +49 511 532 -4296
address: 30625 Hannover, Carl-Neuberg-Str.1, Germany
Building J03, level 03, room 1330
Career
- since 07.2018 Postdoc im Institut für Molekular- und Zellphysiologie an der Medizinischen Hochschule Hannover (MHH)
- 10.2013 to 02.2018 Promotion im Institut für Molekular- und Zellphysiologie an der Medizinischen Hochschule Hannover (MHH)
Current Research Focus
- Characterizing the mechanical and kinetic properties of β-cardiac and skeletal muscle myosin II
- In vitro studies involving modulatory roles of sub-components of motor proteins
- Single molecule analysis of mutant myosin motors implicated in human hypertrophic cardiomyopathy using optical trap and TIRF microscopy
Expertise
- Optical trapping, TIRF Mikroskopie, Rekombinantes Protein mittels gentechnischer Methoden, Proteinherstellung und – aufreinigung.
- Matlab und Labview
Publication and Abstructs
2020
- Acto-Myosin Cross-Bridge Stiffness Depends on the Nucleotide State of Myosin II. Wang T, Brenner B, Nayak A, and Amrute-Nayak M. Nano Letters, 2020 Sep 15. doi: 10.1021/acs.nanolett.0c02960. [Online ahead of print] PubMed
- Single-molecule analysis reveals that regulatory light chains fine-tune skeletal myosin-II function, Nayak A, Wang T, Franz P, Steffen W, Chizhov I, Tsiavaliaris G, Amrute-Nayak M, J Biol Chem. 2020 Apr 9. pii: jbc.RA120.012774. doi: 10.1074/jbc.RA120.012774, PMID: 32273340, Artikel, PubMed
2019
- Mg²⁺ -free ATP regulates the processivity of native cytoplasmic dynein; Behrens VA, Walter WJ, Peters C, Wang T, Brenner B, Geeves MA, Scholz T, Steffen W.; FEBS Lett. 2019 Feb;593(3):296-307. doi: 10.1002/1873-3468.13319. Epub 2019 Jan 3.
2013
- Difference in F-actin depolymerization induced by toxin B from the Clostridium difficile strain VPI 10463 and toxin B from the variant Clostridium difficile serotype F strain 1470; May M, Wang T, Müller M, Genth H. Toxins (Basel). 2013 Jan 11;5(1):106-19. doi: 10.3390/toxins5010106.
2012
- Increased Cell-Matrix Adhesion upon Constitutive Activation of Rho Proteins by Cytotoxic Necrotizing Factors from E. Coli and Y. Pseudotuberculosis. May M, Kolbe T, Wang T, Schmidt G, Genth H. J Signal Transduct. 2012;2012:570183. doi: 10.1155/2012/570183. Epub 2012 Jul 5.