chloride and bicarbonate across the epithelial apical membrane. The CF-causing mutations in the CFTR gene result in either complete loss of function (mutation class I), decreased synthesis of CFTR (class [...] compensate for the underlying defect of CF. Although more than 2000 CF-causing mutations in the CFTR gene are known, the most common mutation p.Phe508del occurs on 70% of all CF chromosomes. p.Phe508del is [...] example to test which environmental factors and which genetic factors outside the causally affected gene modulate the severity of the clinical picture in a congenital disease. For the studies, we have DNA
consequences of distinct gene deficiencies on the function and/or differentiation of iNKT cells. In the course of our earlier work, we already identified several candidate genes and would expect that the [...] the experiments proposed here will unravel additional genes that influence iNKT cell biology.
receptor (TCR) gene transfer Final exam November 2010 Tobias Mätzig GERMANY supervisor: Prof. Dr. Baum, Experimental Hematology, OE 6960, project: Evaluation of retro- and lentiviral vectors for gene therapy [...] now University of Ulm project: Analysis of functional consequences of the deletion of candidate genes of the DNA damage pathway; analysis of a telomerase activating compound in improving liver regeneration [...] supervisor: Prof. Dr. Gaestel, Biochemistry, OE 4310, project: Characterisation of p38 MAPK regulated gene expression in MK2/3 deficient cells Final exam June 2010 Nidhi Narain INDIA supervisor: Prof. Dr.
Freise GERMANY supervisor: Prof. Dr. Zeidler, Dept. Rheumatology, OE 6850, project: Viability and gene expression of Chlamydia trachomatis during persistent infection. A study to establish new therapeutic [...] Feodor-Lynen-Str. 7, 30625 Hannover, project: Regulatory mechanism of mammalian circadian clock genes Final exam June 2006 Yijiang Li CHINA supervisor: Prof. Dr. Haverich/Dr. Simon, THG-Surgery, OE 6286 [...] TURKEY (Dr. med.) supervisor: Prof. Dr. Kreipe, Pathology, OE 5110, project: Quantitative analysis of gene expression in different mechanisms of early allograft damage after renal transplantation Final exam
signalling pathways. This reduces transcriptional noise and fine-tunes gene expression, ultimately regulating the overall gene expression profile of the cell. miRNAs therefore have important functions
protein production (E. coli, D. discoideum, Sf9-cells); Fluorescence Labeling techniques; gene silencing; stable gene expression; polyclonal antibody production. Functional Assays: Determination and chara
rases and Related Genes 1035-1045. Bakker, H. and Ashikov, A. (2014). UDP-Xylose and UDP-N-Acetylglucosamine Transporter (SLC35B4). Handbook of Glycosyltransferases and Related Genes 1393-1402. Bakker [...] and Related Genes 1439-1448. Bakker, H. , Ashikov, A., Routier, F.H., and Gerardy-Schahn, R. (2014). GDP-Fucose Transporter 1 (SLC35C1). Handbook of Glycosyltransferases and Related Genes 1403-1411. Buettner [...] A.C., van Zandbergen,G., Wenzel,A., Gerardy-Schahn,R., Wiese,M., and Routier,F.H. (2007). Targeted gene deletion of Leishmania major UDP-galactopyranose mutase leads to attenuated virulence. J. Biol. Chem
Single Cell Controller The Chromium Single Cell Gene Expression Solution provides a comprehensive, scalable solution for cell characterization and gene expression profiling of hundreds to tens of thousands [...] commercial software currently includes: Feature Extraction (Agilent Technologies) ImaGene (BioDiscovery Inc.) GeneSpring (Agilent Technologies) Omics Explorer (Qlucore) StrandNGS (Avadis) IPA (Qiagen)
in more than 60 genes can lead to proteinuria. Using genetic analysis (whole genome sequencing (WGS)), we search for mutations in previously unknown genes. By characterizing the genes in cell culture and [...] Podocytes form the slit membrane with their foot processes. In particular, mutations in podocytic genes can lead to disorders of the filtration barrier. Clinically, this manifests as increased protein loss [...] D, Callewaert B, van Tilbeurgh H, Zenker M, Antignac C, Hildebrandt F. Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly. Nat Genet. 2017 Oct;49(10):1529-1538. Lovric S
Reports. 2021. Publisher's page Predicting genotoxicity of viral vectors for stem cell gene therapy using gene expression-based machine learning Schwarzer, Adrian, Talbot, Steven R., Selich, Anton, Morgan [...] page Identification and functional characterization of a spliced rhesus rhadinovirus gene with homology to the K15 gene of Kaposi's sarcoma-associated herpesvirus. Wang L, Pietrek M, Brinkmann MM, Havemeier [...] Frontiers in Cellular and Infection Microbiology. 2022. Publisher's page Analysis of myocardial cellular gene expression during pressure overload reveals matrix based functional intercellular communication Froese