Archive HEAL Project Graduation 2023 Winter TACTiC Project Graduation 2022 Summer Generation of human induced pluripotent stem cell lines - Encoding for genetically encoded calcium indicators RCaMP1h and [...] organoids - New publication on a detailed protocol for the production of heart-forming organoids from human pluripotent stem cells Teaching Award of the Student Body 2021 - Outstanding Commitment in Teaching [...] research group can replicate early heart development in the cell culture dish for the first time using human stem cells Scalable Process for Differentiation of Pluripotent Stem Cells into Definitive Endoderm

Abdelilah-Seyfried, S., and Zweigerdt, R. 2024. Transient stabilization of human cardiovascular progenitor cells from human pluripotent stem cells in vitro reflects stage-specific heart development in [...] bioreactor. Application to human induced pluripotent stem cell culture. J Biomech . https://doi.org/10.1016/j.jbiomech.2019.07.021 . Manstein, F., Halloin, C., and Zweigerdt, R. 2019. Human Pluripotent Stem Cell [...] Gohring, G., Martin, U.* , and Merkert, S.*. 2018. Generation of a human CDX2 knock-in reporter iPSC line (MHHi007-A-1) to model human trophoblast differentiation. Stem Cell Res 30:117. *authors contributed

host-cell mechanisms will be validated in relevant infection models such as human organoids, induced pluripotent stem cells, and primary human cells. The Research Training Group ACME's comprehensive training program [...] highly qualified and motivated individuals for 10 PhD Student Fellowships in Infection Biology of Human Pathogens (starting April 1, 2026) The German Research Foundation (DFG) provides funding to Hannover [...] y to perform their cutting-edge PhD work in the rapidly moving field of the infection biology of human pathogens in a highly stimulating, competitive and international environment. Infections are among

02.02.2022 Generation of human induced pluripotent stem cell lines Encoding for genetically encoded calcium indicators RCaMP1h and GCaMP6f Calcium plays a key role in cardiomyocytes (CMs) for the translation [...] not-invasive fluorescence imaging technology allows for the monitoring of calcium transients in human induced pluripotent stem cell derived-cardiomyocytes (hiPSC-CMs) to investigate the cardiac elect [...] Bakar, Sylvia Merkert, Alexandra Haase, Ulrich Martin (LEBAO, MHH) Gudrun Göhring (Department of Human Genetics, MHH) The original paper on ScienceDirect.com Further LEBAO Publications For more information

application of human cardiac muscle cells, small animal models are unfortunately unsuitable, since the heart rate in these animals is much higher than in humans, and transplanted human muscle cells therefore [...] Mar 25;15(1):89. doi: 10.1186/s13287-024-03699-z Transient stabilization of human cardiovascular progenitor cells from human pluripotent stem cells in vitro reflects stage-specific heart development in [...] for individualized Cell Therapy with iPSC-derived Cardiomyocytes Preclinical evaluation in a non-human primate model and a roadmap for clinical application The Federal Ministry of Education and Research

Research at the Department of Human Genetics Our scientific findings make an important contribution to the understanding of ultra-rare genetic diseases, the identification of risk factors for cancer and [...] valuable tool for advances in our field. Find out more about the research groups at the Department of Human Genetics!

Paper in European Heart Journal Murine and human pluripotent stem cell-derived cardiac bodies form contractile myocardial tissue in vitro, European Heart Journal 2013 For the first time, the team of Ina [...] dimensional cardiomyocyte aggregates, so-called cardiac bodies (CBs), that are based on murine and human pluripotent stem cells. The LEBAO team optimized the processes and investigated the role of fibroblasts [...] S., Krause, A., Drager, G., Ochs, M., Haverich, A., Gruh, I.#, and Martin, U.#. 2013. Murine and human pluripotent stem cell-derived cardiac bodies form contractile myocardial tissue in vitro. European

MZP Cardiomyocytes from human induced pluripotent stem cells as a cellular model for hypertrophic cardiomyopathy Researc h focus The focus of our research is the analysis of human induced pluripotent stem [...] β-Myosin heavy chain isoform-expressing myofibrils within human ESC-derived cardiomyocytes recapitulate the contractile features of adult human ventricular myofibrils?, J. Muscle Res. Cell. Motil., 2017 [...] Martin U, Zweigerdt R, Kraft T , Brenner B. Differences in Contractile Function of Myofibrils within Human Embryonic Stem Cell-Derived Cardiomyocytes vs. Adult Ventricular Myofibrils Are Related to Distinct

composition of sarcomeric proteins. Subcellular myofibrils can be obtained from human (e.g., biopsies), human-derived and non-human cardiac and skeletal small muscle samples (e.g., mouse, rat, rabbit, zebrafish [...] maturation of human pluripotent stem cell-derived cardiomyocytes; (2) Understanding the effects of missense mutations in sarcomeric proteins on the subcellular and cellular contractile function in human cardiac [...] School; Research topics: Force-related kinetic studies with subcellular myofibrils using human myocardial samples and human embryonic/induced pluripotent stem cell-derived cardiomyocytes. 2011-2013 : Junior

strong inhibitory and weak stimulatory signals in human immune cells when they interact with porcine tissues. Transgenic (tg) pigs expressing the human (h) inhibitory ligand hPD-L1 (CD274) and pigs lacking [...] vitro studies showed that SLA class I-deficient and hPD-L1 tg cells are only partially protected from human immune responses. We expect that hPD-L1 positive/SLA class I negative cells generated by combining