Research at the Department of Human Genetics Our scientific findings make an important contribution to the understanding of ultra-rare genetic diseases, the identification of risk factors for cancer and [...] valuable tool for advances in our field. Find out more about the research groups at the Department of Human Genetics!

mechanisms. The second part of this project deals with human γδ T cells. We and other could recently show by next generation sequencing of human γδ TCRs that the adult, but not neonatal, γδ TCR repertoires [...] factors might fine-tune the development, organ-specificity and functional adaptation of murine and human γδ T cells. Murine IL-17 producing Vγ6 and Vγ4 T cells develop within an embryonic thymus and are

strong inhibitory and weak stimulatory signals in human immune cells when they interact with porcine tissues. Transgenic (tg) pigs expressing the human (h) inhibitory ligand hPD-L1 (CD274) and pigs lacking [...] vitro studies showed that SLA class I-deficient and hPD-L1 tg cells are only partially protected from human immune responses. We expect that hPD-L1 positive/SLA class I negative cells generated by combining

does not always come easy, we are offering free access to Meditricks - especially for students of human medicine – from 1 October 2024. And this is how it works: Simply register online via Meditricks and [...] Numerous videos, mnemonics and other learning aids are available. Requirement: If you are studying human medicine at the MHH and have an AMBOSS access, you are already perfectly equipped. Where to find

hospitals in Germany, so it is especially valuable for research with human samples/human models. My current project works with human samples, so it is very important for me to have this research environment

the network is establishing new tools and expertise for accelerating the development of advanced human induced pluripotent stem cell (iPSC)-based therapies. The project also aims for overcoming scientific [...] to initiate a first-in-man (FIM) clinical trial for the therapeutic administration of allogeneic, human leukocyte antigen (HLA)-homozygous iPSC-cardiomyocyte aggregates, for improving the function of damaged [...] technologies for allogenic cell therapy to the heart” will focus on overcoming general hurdles to human induced pluripotent stem cell (iPSC)-based therapies, with the particular focus on heart failure,

composition of sarcomeric proteins. Subcellular myofibrils can be obtained from human (e.g., biopsies), human-derived and non-human cardiac and skeletal small muscle samples (e.g., mouse, rat, rabbit, zebrafish [...] Contraction-relaxation function and mechano-chemical coupling of myofibrils Investigations of human, human pluripotent stem cell-derived cardiomyocytes and animal contractile models in non-pathologic and [...] Motorproteinen Characterization of cardiomyocytes from heart tissue and from human stem cells AG Dr. Sarah Konze Cardiomyocytes from human induced pluripotent stem cells as a cellular model for hypertrophic c

IMTTS and Fraunhofer ITEM) Project: Integration and maturation of human stem cell-derived cardiomyocytes and cardiac progenitors on human myocardial slices and their role in tissue injury and regeneration [...] approach Aavani Biju Sindhu INDIA; Sindhu.Aavani @ mh-hannover.de Supervisor: Prof. Dr. Anke Bergmann (Human Genetics) Project: Characterization of molecular mechanisms driving the development and progression [...] Isabel Klefenz GERMANY; Klefenz.Isabel @ mh-hannover.de Supervisor: Prof. Dr. Doris Steinemann (Human Genetics) Project: Genetic causes of immunodeficiencies/predominantly antibody deficiencies (PADs)

What are lymphocytes? Lymphocytes are a fraction of white blood cells and therefore a normal part of human blood. They are used to identify pathogens and eliminate them by immunological defense mechanisms [...] system, and severe infectious diseases, in particular viruses. Lymphocytes can be obtained from human blood without preparatory measures within the framework of so-called cell separation. Procedure of

Projects Phylogeny and Function of Vγ9Vδ2 T cells: Human vs. Camelids (Prof. Dr. Thomas Herrmann) Plasticity of human gamma/delta T cells: (Epigenetic) Modulation by Vitamin C (Prof. Dr. Dietrich Kabelitz)