Future work seeks to explore the contribution of specific human genes towards bacterial pathogenesis and disease. Specifically, we focus on human signaling cascades and cellular pathways which are targeted [...] disease, current projects also focus on human genetics and infectious disease pathology. Overall, these studies are designed to answer the question why human populations exhibit variable susceptibility
Burkhard Tümmler studied biochemistry (1971-1976) and human medicine (1974-1981) and received his doctorates in the fields of physical chemistry and human genetics (Dr. rer. nat. (1979) and Dr. med. (1984)
convinced the DFG and the German Council of Science and Humanities. The German Research Foundation (DFG) and the German Council of Science and Humanities today informed Hannover Medical School (MHH) that the
the network is establishing new tools and expertise for accelerating the development of advanced human induced pluripotent stem cell (iPSC)-based therapies. The project also aims for overcoming scientific [...] to initiate a first-in-man (FIM) clinical trial for the therapeutic administration of allogeneic, human leukocyte antigen (HLA)-homozygous iPSC-cardiomyocyte aggregates, for improving the function of damaged
Zweigerdt Lab Applying human pluripotent stem cells (hPSCs) , we are working on aspects of developmental biology and regenerative medicine focused on the heart as well other tissues and lineages such as [...] Modulation of Histone Acetyl Transferases (IQ-1) and Wnt pathway (CHIR), synergistically stabilize human cardiac progenitors. SCPs depend on NR2F2 to sustain their progenitor phenotype. Upon removal of the [...] foregut endoderm tissues and a vascular network (Figure 3). Besides deciphering complex mechanisms of human organogenesis in a dish , the HFO model can also be used for replacing animal studies in the process
development of human, stem cell-derived cardiomyocytes (hPSC-CMs) Characterization and further maturation of human, stem cell-derived cardiomyocytes (hPSC-CMs) in direct comparison with human, adult card
2122467120 A specific, non-immune system-related isoform of the human inducible nitric oxide synthase is expressed during differentiation of human stem cells into various cell types. Gather F, Ihrig-Biedert [...] Gather F, Vogel T (2022) Int J Mol Sci. 23(2):954. https//doi.org/10.3390/ijms23020954 Regulation of human inducible nitric oxide synthase expression by an upstream open reading frame. Gather F, Schmitz K
the human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) and further validate these findings in living myocardial slices isolated from left ventricular specimens of failing human hearts [...] the hiPSC-CMs and live human myocardial slices with the SARS-CoV-2 virus and analyze the transcriptome to identify potential non-coding RNAs involved in this process. Impact of human glycosylation on the [...] protein levels in rat primary cardiomyocytes. More importantly these findings were also translated into human induced pluripotent stem cell derived cardiomyocytes. We reported the first miRNA candidate that can
Berechnung von Pflegeunterstützungsgeld bei kurzzeitiger Arbeitsverhinderung ) Support from Human Resources Human Resources, service agreements, collective agreements The Service agreements of MHH (e.g. [...] The collective agreements are available on the forms page of Human Resources. If you have further questions, the contact person in Human Resources are happy to assist you. A family member needs care — [...] — what now? An overview is provided on the family page of Human Resources with information on maternity protection, parental leave, and caregiving situations. For any questions related to balancing work
anti-infectives. Microbial metagenome of the respiratory tract The Human Microbiome Project has characterized the microbiome of healthy humans in numerous organs, but has left out the lower respiratory tract [...] Pseudomonas aeruginosa lives in soil, fresh and salt water and colonizes plant and animal surfaces. In humans, P. aeruginosa has become one of the most common bacterial pathogens of local infections of the eye