accumulation of mutations in somatic cells. For the first time in Germany, iPS cells were generated from human cord blood and differentiated into functional cardiomyocytes. In comparison to iPS cells derived from [...] within the scope of the annual general meeting of the GdF for their publication of iPS cells from human cord blood in the renowned journal Cell Stem Cell (Haase et al. 2009). Once a year, excellent researchers
Teilprojekt B1 Visualization of herpesviral infections and the immune response and modulation The humane cytomegalovirus (HCMV) causes, in particular in immunosuppressed patients, significant clinical diseases [...] with the murine CMV (MCMV) in the mouse, however, shows many similarities to the HCMV infection in human beings. Although comprehensive infection experiments with MCMV were carried out, the exact processes
Linden, Ricklingerstr. 5, 30449 Hannover, project: Regulation of chemokine receptor expression on human eosinophils Final exam on November 7th, 2003 (Dr.rer.nat.) Veit Erpenbeck GERMANY (Dr. med.) supervisor: [...] Sellge GERMANY supervisor: Prof. Dr. Bischoff, Gastroenterology and Hepatology, OE 6810, project: Human intestinal mast cells: versatile cells of the intestinal immune system Final exam on November 7th
processing of fresh human tissue and body fluids, as well as biobanking and long-term storage. We are thus generating readily available, expert-assessed and extremely valuable tissues from human and animal hearts [...] LV-endomyocardial biopsies from the DETECT-ID registry. We will characterize the function of isolated human cardiomyocytes from hearts with dilated cardiomyopathy with and without ID. In a new mouse model of [...] repair during cardiac remodeling The aim in the second funding period is to translate these results to human ex-vivo models and to the porcine TAC model as a clinically relevant animal model, to study the in
mechanisms of vasculogenesis. In parallel, we are studying new vessel formation in human renal organoids. We have discovered that human macrophages strongly influence vascularization and endothelial differentiation [...] of renal tissue. The goal is to vascularize organoids and to produce functional kidney tissue from human stem cells. We use zebrafish embryos with genetic markers for renal cells, macrophages and endothelium
logy/ Endocrinology, OE 6819, project: Generation of a functional mouse model with a human immune system and human liver cells for the study of HCV pathogenesis and therapy; study of the functional ability [...] supervisor: Prof. Dr. Ott, Gastroenterology/Hepatology/ Endocrinology, OE 6819, project: Standardised human mesenchymal stem cells for regenerative medicine Final exam June 2010 Natalie Naue GERMANY supervisor:
Montag J., Weber N., Kowalski K. , Mayer A.-K., Iorga B., Brunkhorst A., Zweigerdt R., Kraft T., Human pluripotent stem cell-derived cardiomyocytes mimic intercellular heterogeneity as pathomechanism in [...] Thiemann S., Schwanke K., Lingk A., Krumm U., Piep B., Martin U., Zweigerdt R., Brenner B., Kraft T., In human embryonic stem cell-derived cardiomyocytes twitsch kinetics, action potential parameters and MyH-mRNA [...] kinetics and action potential parameters are independent of expressed myosin heavy chain isoform in human embryonic stem cell-derived cardiomyocytes. 2019, Acta Physiol. 227 (S719):146 Burkart V., Beck J
10.7554/eLife.64881. Repertoire characterization and validation of gB-specific human IgGs directly cloned from humanized mice vaccinated with dendritic cells and protected against HCMV. Theobald SJ, Kreer [...] (collaboration) Polymerization of misfolded Z alpha-1 antitrypsin protein lowers CX3CR1 expression in human PBMCs. Tumpara S, Ballmaier M, Wrenger S, König M, Lehmann M, Lichtinghagen R, Martinez-Delgado B [...] 2014 Nov;44(11):3368-79. doi: 10.1002/eji.201444515. Epub 2014 Sep 19. PMID: 25100508 Activated human hepatic stellate cells induce myeloid derived suppressor cells from peripheral blood monocytes in
Electrophysiological and microscopic characterisation of single neurons in neurosurgical sections of the human neokortex Investigation of Brain-Body-Interactions Development of cell culture models for translational [...] https://doi.org/10.1523/JNEUROSCI.2226-22.2023 All-trans retinoic acid induces synaptic plasticity in human cortical neurons.Lenz, M., Kruse, P., Eichler, A., Straehle, J., Beck, J., Deller, T., & Vlachos,
the dynamics of infection and immune cells with and against HCMV in an infection model of explanted human lungs. Kim Do Thi Hoang DoThiHoang.Kim @ mh-hannover.de Phone: +49 511 532 9738 Kim is part of the [...] de Phone: +49 511 532 9731 Rodrigo is focusing on characterization of the immune response of both humans and mice to prominent pathogens. His main area of expertise is spectra-flow cytometry. Dr. Swantje [...] on developing a reporter system to monitor early events of antigen-dependent T cell activation in humans. She is particularly interested in T cells and their behavior within various immune-related contexts