toring of native and genetically engineered grafts in small and large pre-clinical animal models. Research Fields Transplant Engineering Transplant Immunology Genetic Engineering Cell Pharming PubMed Constanca [...] enabling the genetic modification of solid vascularized organs and vascular composite allografts. In addition, she is highly interested in the large-scale production of genetically engineered cells, including [...] Portugal. In 2003, she initiated her research work in allograft engineering at the Institute of Transfusion Medicine and Transplant Engineering (MHH). After obtaining her doctoral degree in 2006, she continued

Organs, a pioneering project on transplant engineering to combat organ rejection. Research Fields Transplant Engineering Transplant Immunology Genetic Engineering PubMed Rainer Blasczyk Publication list [...] His research aims to prevent transplant rejection by genetic allograft engineering. Professor Blasczyk is considered a pioneer in transplant engineering and highly specialized in the field of histocompatibility [...] rejection and infection. This includes cellular and humoral immunotherapy as well as genetic and transplant engineering approaches to achieve transplantation tolerance. Professor Blasczyk is founder and

screening for footprintless targeted human pluripotent stem cells”, Stem Cell Reports 2014 Genetic engineering of human induced pluripotent stem cells (hiPSCs) via customized designer nucleases has been [...] gene targeting, but still typically depends on the introduction of additional genetic selection. This genome engineering has now been further optimized by scientists from the LEBAO, together with scientists [...] scientists from the departments of Experimental Hematology and Human Genetics (both MHH), as well as with cooperation partners from the University Medical Center Freiburg, as published in “Stem Cell Reports”

Pioneering work on the molecular genetic manipulation of the model organism Dictyostelium discoideum. Key contributions to the development and application of molecular genetics, transient kinetics, and hybrid [...] Application of protein engineering approaches leading to the elucidation of the fundamental principles governing myosin directionality and chemomechanical coupling. Engineering of single-polypeptide myosin

often having no alternative therapeutic option available. Transplant Engineering This area of research focuses on the genetic engineering of cells, tissues and entire organs ( Invisible Organs© ) towards [...] at the Institute of Transfusion Medicine and Transplant Engineering All research at the Institute of Transfusion Medicine and Transplant Engineering is designated to biotechnology approaches in organ and [...] both the national and international level. Among the allograft engineering developments, Invisible Organs created by transplant engineering are addressing the burden of rejection and the acute shortage

Annual Retreat 2023 Suganya Annadurai on her work about the genetic engineering of Limbal Stem Cells and Limbs during Ex vivo Machine Perfusion towards improving graft survival after allogeneic transplantation

with low stimulatory potential for the potential transplant recipient. Together with further "genetic engineering" in the context of ex vivo perfusion, it is thus possible to select or generate a xenograft [...] project together with Prof. Constanca Figueiredo (MHH, Dept. of Transfusion Medicine and Transplant Engineering).

mechanism of γδ TCR activation, in order to enhance tumour killing (Prof. Dr. Wolfgang Schamel) Genetically engineered chicken models: novel tools to investigate lymphocyte development and function (Prof. Dr

REBIRTH. A high degree of interdisciplinary collaboration, including chemistry, physics, and engineering science, is the basis of REBIRTH research. Therefore, scientists from the MHH, the Leibniz University [...] the Fraunhofer Institute for Toxicology and Experimental Medicine, the Institute of Farm Animal Genetics in Mariensee, the Helmholtz Centre for Infection Research in Braunschweig, the Laser Zentrum Hannover [...] cardiovascular and respiratory diseases, and especially on induced pluripotent stem cells, tissue engineering, and the development of biohybrid implants and organs. The REBIRTH speaker, Prof. Axel Haverich

application and disease modelling. Key aspects of our research, i.e. stem cell research and tissue engineering have a very interdisciplinary character, including aspects of biology, chemistry and physics, as [...] international partners. The group was established as a junior research group for ‘Myocardial Tissue Engineering’ within the cluster of excellence REBIRTH , and receives ongoing support from the 'REBIRTH - Research [...] neonatal rat cardiomyocytes. Together with Leibniz University Hannover, we tested matrices for tissue engineering, including methacrylated alginate and hyaluronic acid blends and novel in situ cross-linking polymers