organ nevertheless remains as small and effective as possible, as is the case with the human lung. In the human lung, about 100 to 140 square meters of breathing surface are packed into 300 million alveoli [...] artificial lungs can be transplanted into the human body. The DFG Priority Program SPP 2014 is funding a total of ten projects throughout Germany. The lead institutions are the Rheinisch-Westfälische Technische [...] g endothelial cells. "These endothelial cells, which are not endogenous to the body, are also genetically modified so that they are virtually invisible to the patient's immune system and are therefore

the Paul Ehrlich Institute are monitoring the four-year project. If everything goes as planned, the researchers hope, prerequisites for a clinical trial of cell-based heart repair in humans can subsequently [...] over Europe and Israel, with more than six million euros, of which the MHH as the coordinating institution is receiving 1.4 million euros. Bringing heart muscle cells to the target In many heart diseases [...] is impaired. Unlike in some amphibians and fish species, such damage is not repaired in an adult human heart. Scientists around the world are therefore working on strategies to replace destroyed heart

Head of the Institute of Experimental Haematology at Hannover Medical School (MHH), and Prof. Dr Armin Braun, Head of Preclinical Pharmacology and Toxicology at the Fraunhofer Institute for Toxicology [...] successfully tested the efficacy and safety of our RNAi candidates on human lung tissue slices and in 3D cell cultures from human lung epithelium and animal models," explains Professor Dr Armin Braun, [...] place on the viral RNA, rendering it unreadable and initiating its degradation. As a result, the genetic blueprint it contains is not realised and virus replication is blocked. "We have now developed suitable

Hannover Medical School (MHH) led by Professor Dr Hildegard Büning, AAV expert and deputy head of the Institute for Experimental Haematology, has developed two new AAV variants that are more effective and can [...] viral envelope, the so-called capsid, the AAV vectors dock onto the body cell and smuggle their genetic cargo into the cell interior. There it is read and converted into the corresponding protein according [...] library among more than one million AAV variants, which function both in mouse liver cells and in human liver cells. "This cross-species application possibility is very important for the development of

cells are deposited, the so-called fibrosis. For years, Professor Dr. Dr. Thomas Thum, head of the Institute for Molecular and Translational Therapy Strategies at the Hannover Medical School (MHH), has been [...] research team are focusing on so-called long non-coding RNAs (lncRNA). These are building blocks of our genetic material that are not responsible for the production of proteins, but control certain processes in [...] team investigated whether the Meg3 inhibitor could also stop fibrosis and improve heart failure in human heart muscle cells and heart tissue. "Our revolutionary technology worked excellently," the cardiologist

the Institute for Transfusion Medicine and Transplant Engineering, the Institute for Diagnostic and Interventional Radiology , the Department of Paediatric Haematology and Oncology and the Institute for [...] 2023 Human polyomavirus 2 - formerly called John Cunningham (JC) virus - infects about 70 to 90 percent of all people worldwide without most even noticing it. But once it enters the body, the genetic material [...] explains Professor Dr. Britta Eiz-Vesper, immunologist at the MHH Institute of Transfusion Medicine and Transplant Engineering . Because the institute is not only one of Germany's leading producer for virus-specific

same for patients who did or did not meet the LFS genetic cancer criteria, differences were seen in tumor patterns. "Patients who met the LFS genetic testing criteria had a higher incidence of early adrenal [...] who did not meet the genetic testing criteria had a higher incidence of breast and other cancers, 45 per cent of which occurred after the age of 45," Professor Hainaut of Institute for Advanced Biosciences [...] the Federal Ministry of Education and Research and by the Canadian Institutes of Health Research and the Terry Fox Research Institute. SERVICE: For further information , please contact Professor Dr. Christian

long time. A research team led by Professor Dr. Andreas Kispert and Dr. Mark-Oliver Trowe from the Institute of Molecular Biology at the Hannover Medical School (MHH) has now found the key and demonstrated [...] a so-called transcription factor. Like an on-off switch, this protein regulates whether certain genetic information on the DNA should be read or not. "We studied the cochlea in the mouse model and found [...] the outer hair cells causes them to convert to inner hair cells." Since the inner ear of mice and humans is similar, the researchers assume that the regulatory pathways are also transferable. The identification

body's own substance spermidine. A research group led by Professor Dr. Evgeni Ponimaskin from the Institute of Neurophysiology at the Hannover Medical School (MHH) has now uncovered the systemic effects and [...] Telomeres protect the ends of chromosomes in our body's cells from degradation. Chromosomes carry our genetic information. With each cell division, their ends shorten a bit. In cells that no longer divide - [...] our body cells, spermidine supplementation could also protect against many age-related diseases in humans. Keyword spermidine: Spermidine is an endogenous, natural substance. It was first discovered in male

caused by viruses, fungi and bacteria. A research team led by Dr Anna Christina Dragon from the Institute of Transfusion Medicine and Transplant Engineering at Hannover Medical School (MHH) is now developing [...] rejection," explains the young scientist. The structures on the surface of the body cells, the so-called human leukocyte antigens (HLA), are decisive for this. Based on these tissue characteristics, our immune [...] immune cells of the patient – the so-called T cells – which we convert into killer cells through genetic modification so that they precisely eliminate the responsible B cells that would otherwise produce