that pathogenic variants in BRCA1/2 and the MMR genes may also contribute to the risk of cancer in individuals below age 18 years. "Children and adolescents with BRCA1/2 or MMR gene variants were mainly [...] 24.08.2022 Pathogenic variants in BRCA1/2 genes are associated with an increased risk of breast and ovarian cancer in adults and variants in mismatch repair (MMR) genes increase the risk of gastrointestinal [...] patients it become possible to demonstrate a statistically significant enrichment of variants in the BRCA1/2 or MMR genes in children and adolescents with cancer compared to two control populations," Kratz explains

currently dominant coronavirus variant XBB.1.5, but also activates the body's own defences against the currently spreading variants "Pirola" (BA2.86) and "Eris" (EG1.5). "The B cells that produce antibodies [...] vaccine is also adapted to XBB.1.5, we expect it to be equally effective." The same applies to the booster vaccine from the manufacturer Novavax, which has also been adapted to XBB.1.5 and authorised by the European [...] The new booster vaccines from Biontech and Moderna are specially adapted to the Omikron subline XBB.1.5. However, the effectiveness of the new boosters has not yet been proven. A study by the Department

ingredients ivosidenib and azacitidine. While the former inhibits a specific gene-modified enzyme called IDH1 that promotes the development of blood cancer cells, the latter prevents cancer cells from growing. [...] two drugs improved survival in people newly diagnosed with AML that had gene alterations in the IDH1 enzyme. However, the standard treatment is currently still either chemotherapy or stem cell transplantation [...] or who, after initial improvement, have subsequently relapsed. They are to be treated with the IDH1 inhibitor ivosidenib in combination with the active substance molidustat. The drug stimulates the production

catch-up investments at universities under state responsibility" in the amount of 2.1 billion euros. Half of this special fund (1.05 billion euros) is earmarked for the new MHH building, the other half for the [...] "DBHN has examined construction stage 1 on the basis of the construction development plan and has given a positive vote. With the inclusion of construction stage 1 in the financing plan for measures, the [...] MHH new building is well on its way." Space for 562 beds and 24 operating rooms Construction stage 1 comprises the functional areas of the central emergency department, emergency and trauma, heart and

in IDH1-Mutated Acute Myeloid Leukemia" can be found here . The publication on the investigations in the mouse model "Synergistic activity of IDH1 inhibitor BAY1436032 with azacitidine in IDH1 mutant [...] been used individually against AML. While the first inhibits a certain gene-modified enzyme called IDH1, which promotes the development of blood cancer cells, the second prevents the cancer cells from growing [...] able to demonstrate this effect in humans who had newly diagnosed AML with gene alterations in the IDH1 enzyme. "We were surprised that the effect was so strong," emphasises the physician. The interaction

day in 2022 in the Department of Obstetrics and Gynaecology at the Medical School (MHH). Of these, 1.295 were girls. 113 families were happy about twins, five even about triplets. With the total number [...] were born at the MHH. One of the first newborn babies in 2023 was Luca. He was born at 5.50 a.m. on 1 January and weighed a good 3.800 grams. The parents, Mihaela-Florina and Bogdan M., are thrilled with [...] "The babies were more relaxed." Highest possible level of care for mother and child MHH is a Level 1 Perinatal Centre, and in 2022 this certificate was reconfirmed in a surveillance audit: MHH meets all

"Human Lentiviral Gene Therapy Restores the Cellular Phenotype of Autosomal Recessive CompleteIFN-γR1 Deficiency" with Professor Nico Lachmann, MD, MHH Department of Pediatric Pneumology, Allergology and [...] he tested novel gene ferries. In doing so, he successfully demonstrated the correction of the IFN-γR1 signaling protein in human target cells. In addition to mycobacteria causing tuberculosis, so-called [...] marrow transplantation is an option. This particularly severe form of MSMD due to mutations in the IFN-γR1 gene is therefore the focus of the development of new forms of therapy. Current treatment methods are

Haematology and Oncology of MHH. 3,034 patients from 1,282 families analysed The research team used the classification to analyze data from 3,034 patients from 1,282 families with a hereditary TP53 variant from [...] meet the LFS genetic test criteria and did not develop cancer before the age 18 years. 33 people (1.1 per cent) were cancer-free carriers and relatives of these patients. While the lifetime risk was about

planned beds remained constant at 1,520, including 166 intensive care beds. International - also in teaching The MHH remains one of the most international places in Lower Saxony: 1,061 people (12.5%) with foreign [...] In 2022, researchers used a total of 101.4 million euros for their projects, which employed nearly 1,400 people. In 2022, 585 new projects were started. This means that the MHH remains one of the most [...] Committee of the Lower Saxony State Parliament recently approved the measure financing plan for the 1st construction phase of the new health care building. Coordination with the region and the state capital

themselves, among other things, to a certain protein called HIP1R, which is found throughout the body and not only in the liver. "With this binding to HIP1R, we can detect the polyreactive immunoglobulins and use [...] quickly and reliably than previous standard tests. For this purpose, the scientists examined more than 1,000 blood samples from ten European centres for liver diseases. The results have been published in the