organoid for the first time. Robert Zweigerdt, Miriana Dardano, Lika Drakhlis (from left) How do human organs develop and what happens to them when they become diseased? To answer these questions, researchers [...] producing a heart-forming organoid (HFO) and reproducing the entire path to the early stage of a human heart in cell culture. One unsolved problem in science to date has been the development of a model [...] that simulates heart development and haematopoiesis in combination. Haematopoiesis begins in the human embryo after the fourth week in the aorta, close in time and location to the cardiac anlage. Building

computer-assisted and statistical approaches to investigate the effect of genetic factors - at a variety of molecular levels (e.g. genetics, metabolomics), immunological parameters and functions as well as infectious [...] sciences. The "Who's Who" of science also provides information about the countries and research institutions in which the scientific elite work. 336 of these experts work in Germany, putting it in fourth [...] pulmonary hypertension, i.e. pulmonary hypertension. Professor Dr Thomas Thum is Director of the MHH Institute for Molecular and Translational Therapy Strategies. For many years, the cardiologist and bioscientist

at the Institute of Transfusion Medicine and Transplant Engineering . Hereditary primary haemochromatosis is one of the most common inborn errors of metabolism in Europe. The cause is a genetic defect [...] approach, but also for translational application in other monogenetic diseases and those in which genetic effectors play a central role. The prize was awarded on 1 July during the 19th HepNet Symposium.

study in humans The combination has already been shown to work in human AML cell cultures and in mouse models. Now the efficacy, safety and tolerability of the new therapy are to be tested in a human clinical [...] cells of the hematopoietic system proliferate uncontrollably. This form of blood cancer is caused by genetic changes in the bone marrow that occur in the course of life. It is therefore mainly older people

cell-based therapies will provide innovative therapeutic strategies for the treatment of various genetic and acquired diseases. Recently, the possibility to reprogram normal somatic cells into induced [...] Martin - in collaboration with a group from Zürich - artificially introduced an ion channel into human iPS cells. Physiological occurrence of this ion channel is restricted to the thyroid and the stomach [...] Hoerstrup S, Luescher TF, Kaufmann PA, Landmesser U*, Martin U*: Transplantation and tracking of human-induced pluripotent stem cells in a pig model of myocardial infarction: assessment of cell survival

and thus trigger leukaemia. Now, an international research team led by Dr. Michael Rothe from the Institute of Experimental Haematology at the Hannover Medical School (MHH) has developed a safety test that [...] studies, however, individual patients developed leukaemia after they had been transplanted with the genetically modified blood stem cells. "This happens when the vector inserts itself near cancer genes and activates [...] conclusive," the scientist emphasises. The IVIM (In Vitro Immortalisation) test developed at the Institute of Professor Dr Axel Schambach several years ago and approved in the USA, Canada, Australia and

the first bioengineered rAAV to enter clinical evaluation. In 2012, he was recruited by the Salk Institute for Biological Studies to oversee their Gene Transfer, Targeting and Therapeutic (GT3) facility [...] facility. In 2015, he was recruited by the University of Sydney / Children’s Medical Research Institute (CMRI) to establish his independent research team, Translational Vectorology Research Unit (TVRU), and to [...] a number of gene therapy programs that aim to develop novel advanced therapeutics for paediatric genetic disorders affecting the CNS, lungs, liver and other organs.

and Toxicology human medicine, 3rd year of study Organized by: Prof. Dr. rer. nat. Harald Genth (Prof. Dr. med. Ingo Just), Institute of Toxicology Prof. Dr. med. Roland Seifert, Institut of Pharmacology [...] nutrition (anorexia and obesity) human Medicine, from the 3rd year of study Organized by: Prof. Dr. med. Roland Seifert, Institut of Pharmacology Dr. med. Bastian Schirmer, Institut of Pharmacology Curriculum [...] materials MSE_P_509 Clinical Pharmacology and Pharmacotherapy human medicine, 5rd year of study Organized by: Prof. Dr. med. Dirk.O. Stichtenoth, Institute of Clinical Pharmacology Curriculum more details MSE_P_312

are also life threatening, e.g. Cystic Fibrosis (CF) and surfactant deficiencies (SD). CF is a genetic disease, resulting in a dysfunction of the „Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)“ [...] respiratory system. Cell replacement therapies could be used to regenerate normal lung function in both genetic and acquired pulmonary diseases. Pluripotent stem cells represent a suitable cell source due to their [...] huge impact for both the optimization of differentiation protocols as well as for drug-screening are human iPS reporter cell lines which are generated using TALEN-based homologues recombination ( RG Martin

Hochschule Hannover, the Fraunhofer Institute for Toxicology and Experimental Medicine, the Institute of Farm Animal Genetics of the Friedrich-Loeffler-Institute (FLI) Mariensee, the Helmholtz Centre [...] Centre for Infection Research Braunschweig and the Max Planck Institute for Molecular Biomedicine Münster. The consortium addresses some of the big questions in health research as well as the associated challenges [...] Structure of Organisation & Governance Coordinators Coordinator: Prof. Dr. Dr. Thomas Thum The Institute of Molecular and Translational Therapeutic Strategies (IMTTS) E-Mail: Thum.Thomas(at)mh-hannover