childhood myelodysplastic syndromes--challenge for the detection of chromosomal imbalances by array-CGH. Genes Chromosomes Cancer. 2010 Oct;49(10):885-900. Greten TF, Ormandy LA, Fikuart A , Höchst B, Henschen [...] stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis, Genes Dev. 2010 Aug 1;24(15):1659-72 Stankov MV1, El Khatib M1, Thakur BK, Heitmann K , Panayotova-Dimitrova [...] Bernateck M, Tran AT, Holm L, Volkmann L, Buers D, Karst M, Stuhrmann M. Catechol-O-methyltransferase gene polymorphisms are not associated with multisomatoform disorder in a group of German multisomatoform
dos Remedios C., Hilfiker-Kleiner D., Kraft T., Montag J. Burst-like transcription of sarcomeric genes in hypertrophic cardiomyopathy. 2021, Biophysical Society Journal, Vol. 120, Issue 3, Suppl. 1, 103a [...] dos Remedios C., Hilfiker-Kleiner D., Kraft T., Montag J. Burst-like transcription of sarcomeric genes is associated with cell-to-cell allelic and functional heterogeneity in Hypertrophic Cardiomyopathy;
focus of our lab is on the identification and functional characterization of epigenetic signature genes in T cells and ILC lineages, which will be an important step for the discovery of key pathways and
expressed proteins over RNA extraction of FFPE material and consecutive analysis of compartment specific gene expression to high resolution x-ray imaging allowing for example the characterization of the inflammatory
is the structured integration of different data sources (medical reports, laboratory data, x-rays, gene sequencing data, etc.) within the MHH. Various institutes and departments of the MHH cooperate with
, Faix, J., Di Donato, N., Taft, M. H. , Manstein, D. J. (2022) Frameshift mutation S368fs in the gene encoding cytoskeletal β-actin leads to ACTB-associated syndromic thrombocytopenia by impairing actin [...] Taft, M. H. , Manstein, D. J., and Henn, A. (2017) N-terminal splicing extensions of the human MYO1C gene fine-tune the kinetics of the three full-length myosin IC isoforms. J. Biol. Chem. pii: jbc.M117.794008
doi:10.1038/icb.2016.40. Georgiev, H.; Ravens, I.; Benarafa, C.; Förster, R.; Bernhardt, G. Distinct Gene Expression Patterns Correlate with Developmental and Functional Traits of INKT Subsets. Nat. Commun
children and family planning in organ transplants Molecular Perinatology: ► Regulatory mechanisms of gene expression linking impaired vascular health with preeclamptic pregnancies ► Epigenetic differences
markers, such as beta-MyHC. The matured cardiomyocytes are then screened for potential differences in gene expression, contractile features, calcium transients and alignment of myofibrils between hiPSCs-CMs
Pokrant T., Faix J., Di Donato N., Taft M.H., Manstein D.J. (2022) Frameshift mutation S368fs in the gene encoding cytoskeletal β-actin leads to ACTB -associated syndromic thrombocytopenia by impairing actin [...] Taft, M. H., Manstein, D.J. and Henn, A. (2017) N-terminal splicing extensions of the human MYO1C gene fine-tune the kinetics of the three full-length myosin IC isoforms. J Biol Chem, 292, 17804-17818 [...] P. & Hunt, D.M. (1995) Cloning vectors for the production of proteins in Dictyostelium discoideum Gene 162 , 129-134. ( Abstract ) ( pdf, 436 kB) Schröder, R.R., Manstein, D.J., Jahn, W., Holden, H.M.