kinetic properties of β-cardiac and skeletal muscle myosin II Investigation of human ventricular myosin mutations implicated in human hypertrophic cardiomyopathy Development of optical trap technique Publications: [...] based on natural building blocks Single molecule analysis of mutant myosin motors implicated in human hypertrophic cardiomyopathy Epigenetic regulation of straited muscle physiology by ubiquitin-like [...] naturally occurring mutations in sarcomereic proteins implicated in hypertrophic cardiomyopathy (HCM) in humans. Contact Dr. Mamta Amrute Dr. rer. nat. Tianbang Wang Dr. Tianbang Wang finished his doctoral studies
Project leader: Prof. Dr. Danny D Jonigk, FRCPath Department / Institute: Institute of Pathology Human Non neoplastic interstitial lung diseases are complex, ill understood and consist of >120 defined [...] rypsin (A1AT) is an acute-phase glycoprotein and one of the most abundant protease inhibitors in humans. A1AT is also characterized as a protein with broad immunomodulatory and immunosuppressive capacities
The aorta is the largest blood vessel in the human body. It originates in the heart and carries oxygen-rich blood to all parts of the body. The most common disease of the aorta that requires treatment [...] by it reflexively. The silk is extremely thin and tear-resistant and completely degradable in the human body. Using a special apparatus that assistant physician Dr Helms constructed himself, the thread
"We have successfully tested the efficacy of our RNAi candidates on human lung tissue sections as well as in 3D cell cultures from human lung epithelium," explains Professor Dr. Armin Braun, Head of Preclinical
treated for six months a total of five times with mesenchymal stem cell products obtained from a human umbilical cord. "The treatment led to a significant improvement in growth, exercise tolerance and [...] stem cell therapy is based on cells from the umbilical cord of newborns and is also called HUCMSC (human umbilical cord mesenchymal stem cell). The researchers' analyses showed that the products of these
Korf-Klingebiel, biologist and first author of the study. Whether all of this is also significant for humans was investigated by the team in patients with heart failure due to aortic stenosis. In this disease [...] laboratory, the MYGDF level dropped to normal. Pressure overload thus also leads to MYDGF release in humans. The work shows that the positive aspects of inflammation must be considered when thinking about
pediatrics and adolescent medicine and heads the working group for experimental neonatology. She studied human medicine in Bochum, Strasbourg and Boston. She started her training as pediatrician at the University
elucidation of the molecular mechanisms of proteins whose function is vital for the health of the human organism. Combining leading techniques for structure determination with state-of-the-art cell biological
Research Topic : Developing an in vitro test system to predict immunogenicity of biological compounds in humans Supervisor : Prof. Dr. Reinhold Förster, Institute of Immunology, MHH and Prof. Dr. Armin Braun,
establish an ex vivo organ-/immune-system interface simulating immune responses after engraftment of human donor livers. Precision-cut slices of donor livers performed prior engraftment serve as a three-d