interaction of Pseudomonas aeruginosa and the human host microenvironment in development of persistent infection in the lower respiratory tract of humans Supervisor: Prof. Dr. Susanne Häußler, Institute [...] University, La Paz, Bolivia Miriam Nörder Research Topic: Development of mice containing the human immune system and/or human liver for the preclinical validation of vaccine candidates Supervisor: Prof. Dr. Carlos [...] University of Delhi South Campus, India Rita Haller Research Topic: Staphylococcal manipulation of human cell signaling systems Supervisor: Dr. Volker Winstel, Pathogenesis of Bacterial Infections, Twincore

to combine translational stem cell research with basic biology in order to gain new insights into human hematopoietic development and related disease pathophysiology of congenital diseases with a strong

The aorta is the largest blood vessel in the human body. It originates in the heart and carries oxygen-rich blood to all parts of the body. The most common disease of the aorta that requires treatment [...] by it reflexively. The silk is extremely thin and tear-resistant and completely degradable in the human body. Using a special apparatus that assistant physician Dr Helms constructed himself, the thread

"We have successfully tested the efficacy of our RNAi candidates on human lung tissue sections as well as in 3D cell cultures from human lung epithelium," explains Professor Dr. Armin Braun, Head of Preclinical

treated for six months a total of five times with mesenchymal stem cell products obtained from a human umbilical cord. "The treatment led to a significant improvement in growth, exercise tolerance and [...] stem cell therapy is based on cells from the umbilical cord of newborns and is also called HUCMSC (human umbilical cord mesenchymal stem cell). The researchers' analyses showed that the products of these

Korf-Klingebiel, biologist and first author of the study. Whether all of this is also significant for humans was investigated by the team in patients with heart failure due to aortic stenosis. In this disease [...] laboratory, the MYGDF level dropped to normal. Pressure overload thus also leads to MYDGF release in humans. The work shows that the positive aspects of inflammation must be considered when thinking about

Project leader: Prof. Dr. Danny D Jonigk, FRCPath Department / Institute: Institute of Pathology Human Non neoplastic interstitial lung diseases are complex, ill understood and consist of >120 defined [...] rypsin (A1AT) is an acute-phase glycoprotein and one of the most abundant protease inhibitors in humans. A1AT is also characterized as a protein with broad immunomodulatory and immunosuppressive capacities

Fedorov, R., Henn, A., Taft, M. H. #, and Manstein, D. J.# (2020) Mechanochemical properties of human myosin 1C are modulated by isoform-specific differences in the N-terminal extension. J Biol Chem. [...] and Gunning, P. W. (2018) Co-polymers of Actin and Tropomyosin Account for a Major Fraction of the Human Actin Cytoskeleton. Curr. Biol. 28, 2331-2337.e5. doi: 10.1016/j.cub.2018.05.053. Latham, S. L., Ehmke [...] A. O., Taft, M. H. , Manstein, D. J., and Henn, A. (2017) N-terminal splicing extensions of the human MYO1C gene fine-tune the kinetics of the three full-length myosin IC isoforms. J. Biol. Chem. pii:

cells with cloned human cytomegalovirus genomes. Viruses 6: 354-370. 67. Gabaev, I., Elbasani, E., Ameres, S., Steinbruck, L., Stanton, R., Doring, M., et al (2014) Expression of the human cytomegalovirus [...] Barchanski, A., Lindner, R., Noyan, F., Suhs, K. W., et al. (2018). RNA interference efficiently targets human leukemia driven by a fusion oncogene in vivo. Leukemia 32, 224-226. 5. Kommerein, N., Doll, K., Stumpp [...] Buch, A., Sodeik, B., and Werfel, T. (2018). RNase 7 Strongly Promotes TLR9-Mediated DNA Sensing by Human Plasmacytoid Dendritic Cells. J Invest Dermatol 138, 872-881. 7. Latham, S. L., Ehmke, N., Reinke

where mutations in the C-mannosyltransferase gene lead to a temperature-sensitive DumPY phenotype. In humans there are four homologs of DPY-19, which are called DPY19L1, DPY19L2, DPY19L3, and DPY19L4.