Centre for Molecular Medicine Cologne, he succeeded in casting the initial idea of a directed T-cell response into a solid concept of "CAR engineering", which has been taken up by many groups at home and [...] where he holds the Chair of Gene Immunotherapy, has played a major role in establishing the Leibniz Institute for Immunotherapy (LIT) and is a member of the directorate there. Overcoming therapy resistance [...] neighbouring cells. The ATP binds to special receptors (P2X4 receptors) on the surface of surrounding tumour cells, which immediately activates a survival mechanism (mTOR signalling pathway) in these cells

rinology, OE 6810, project: Regulation of the turn over of mitotic cyclins like cyclin B or cyclin A by proteolytic mechanisms and role in the development of human malignancies Final exam November 2008 [...] GERMANY supervisor: Prof. Dr. Gaestel, Physiological Chemistry, OE 4310, project: Interaction between the p38 MAP kinase signaling cascade and Polycomb group proteins: analysis of structure and function of MK2-Edr [...] logy/Hepatology/ Endocrinology, OE 6810, project: Signaling mechanism(s) of Helicobacter pylori VacA cytotoxin and disturbance of epithelial secretary function Final exam June 2008 Kirsten Sommer (Dr.med

INDIA supervisor: Dr. Luchtefeld, Cardiology, OE 6880, project: Role of TNF-a antagonism on atherosclerotic plaque development in a humanized mouse model from October 2012: University Giessen und Marburg GmbH [...] supervisor: Prof. Dr. Gaestel/ Dr. Menon, Physiological Chemistry, OE 4310, project: The role of the p38 MAPK/Mk- pathway in the regulation of cytoskeletal dyanamics and intracellular Transport Final exam [...] Physiological Chemistry, OE 4310, project: Role of THOC5 in cell proliferation/differentiation and as a target for cancer therapy Final exam November 2014. Björn Schulte GERMANY supervisor: Dr. Wölk, Virology

Vol. 77:676-686 PubMed Roels B., Reggiani C., Reboul C., LionneC., Iorga B., Obert P., Tanguy S., Gibault A., Jougla A., Travers F., Millet G., Candau R. (2008) “Paradoxial effects of endurance training [...] chlorophyll-a by beta-carotene in benzene. 1990-1995 : University studies in Physics (1995, B.Sc.), Faculty of Physics, University of Bucharest; Research topic: Spectrophotometrical study of chlorophyll-a species [...] Iorga B., Fischer M., Geers-Knörr C., Hegermann J., Wrede C., Fiedler J., Kempf H., Franke A., Piep B., Pfanne A., Thum T., Martin U., Brenner B., Zweigerdt R., Kraft T. (2016) “Stiff matrix induces switch

research into artificial joint replacement with a wide range of clinical issues. The Department offers a range of services and procedures and has built up a broad spectrum of methods in numerous projects [...] rate Optical measuring systems NDI Polaris P4 NDI Optotrak Certus Fluoroscope Generator output: Conduction: 40kV to 110kV/0.2 to 6mA Absorption: 40kV to 110kV/20mA Operating frequency: 20Hz Max. Operating [...] Operating data: Transmission: 100kV/0.2-6mA Recording: 110kV/20mA Exception time: 0.1 to 4 seconds X-ray control area: Double focus standing anode tube Image intensifier tube: 17/10 cm or 23/15 cm, caesium - iodide

With a molecular weight of 150 kDa, the BoNTs are classic AB toxins (Fig. 2) and consist of a light chain (LC) with 50 kDa and a heavy chain (HC) with 100 kDa, which are covalently linked via a disulfide [...] 1970, seven serotypes BoNT/A-G were identified which differ in the amino acid sequence from 37.2% to 69.6% [ 5 , 6 ]. In October 2013, a new BoNT serotype HA, which is produced by a bivalent C. botulinum strain [...] HC is divided into a translocation domain HN and a receptor binding domain HC, each with 50 kDa. Scientific foci Fig. 3: Crystal structure of the 760 kDa BoNT (L-) complex [17]. BoNT/A (lilac), non-toxic

want to participate in a pulmonary function diagnosis and a fitness test, i.e. a 6-minute walk test, give a blood sample for the definition of their immune profile and answer a questionnaire. We expect [...] specific questionnaire (Fatigue Assessment Scale, FAS). In addition a testing of lung function and endurance (6-MWT) will be performed, as well a blood testing (FACS, ELISA, Neurodisorder assay) to quantify [...] beginning and are randomized in an intervention- and a waiting-control-group. After randomization patients in the intervention-group will participate in a homebased 3 month rehabilitation program using te

diseases) at Ulm University Hospital since 2000. She heads a collaborative research centre and a research group in the field of leukaemia research. She is a member of the Young Investigators Committee of the German [...] treatment concepts for this form of leukemia. They have made a significant contribution to the development of the University of Ulm into a world-leading hematology center. In addition, they have rendered [...] on colorectal cancer as a junior research group leader since 2012. Together against AML - Prof. Dr. Konstanze Döhner and Prof. Dr. Hartmut Döhner Acute myeloid leukaemia (AML) is a rare disease with 3.5

M, et al. A Cardiac Cell Outgrowth Assay for Evaluating Drug Compounds Using a Cardiac Spheroid-on-a-Chip Device. Bioengineering (Basel, Switzerland). 2018;5(2). Koch L, Deiwick A, Franke A, Schwanke K [...] demonstrate potential risks in a human-related animal model. In conclusion, considering the current state of worldwide research, the use of NHPs is – from a scientific as well as from a clinical perspective - [...] hiPSC-CMs in patients suffering from right-sided heart failure as a long-term consequence of a Mustard operation and submission of a first draft of an application protocol. Updating the ‘Freedom to Operate

9(1):7486. Dai Z, Song G, Balakrishnan A, Yang T, Yuan Q, Mobus S, Weiss AC, Bentler M, Zhu J, Jiang X, Shen X, Bantel H, Jaeckel E, Kispert A, Vogel A, Saborowski A, Buning H, Manns M, Cantz T , Ott M, [...] Gensch I, Wähner A, Beh-Pajooh A, Mussolino C, Tauscher M, Steinemann D, Wegner F, Petri S, Schambach A, Charpentier E, Cathomen T, Cantz T (2016). Improved bi-allelic modification of a transcriptionally [...] Eggenschwiler R, Patronov A, Hegermann J, Fraguas-Eggenschwiler M, Wu G, Cortnumme L, Ochs M, Antes I, Cantz T (2019). A combined in silico and in vitro study on mouse Serpina1a antitrypsin-deficiency mutants