Centre for Molecular Medicine Cologne, he succeeded in casting the initial idea of a directed T-cell response into a solid concept of "CAR engineering", which has been taken up by many groups at home and [...] where he holds the Chair of Gene Immunotherapy, has played a major role in establishing the Leibniz Institute for Immunotherapy (LIT) and is a member of the directorate there. Overcoming therapy resistance [...] neighbouring cells. The ATP binds to special receptors (P2X4 receptors) on the surface of surrounding tumour cells, which immediately activates a survival mechanism (mTOR signalling pathway) in these cells

for applicants Before submitting an application, you must create a user account, which will be activated by the Ethics Committee office. A 2-factor authentication using an authenticator app is required. [...] accordance with professional law §15 MBO (non-MPDG and non-AMG studies) could previously be submitted with a paper copy (original) + electronically on CD, USB stick or by email (Ethik Commission@mh- hannover.de) [...] January 2018) that were not originally submitted via ethikPool? 1. If you haven't already done so, create a user account at www.mhh-ethikkommission.de/app/ . 2. Inform the Ethics Committee office by email (i

M, et al. A Cardiac Cell Outgrowth Assay for Evaluating Drug Compounds Using a Cardiac Spheroid-on-a-Chip Device. Bioengineering (Basel, Switzerland). 2018;5(2). Koch L, Deiwick A, Franke A, Schwanke K [...] demonstrate potential risks in a human-related animal model. In conclusion, considering the current state of worldwide research, the use of NHPs is – from a scientific as well as from a clinical perspective - [...] hiPSC-CMs in patients suffering from right-sided heart failure as a long-term consequence of a Mustard operation and submission of a first draft of an application protocol. Updating the ‘Freedom to Operate

With a molecular weight of 150 kDa, the BoNTs are classic AB toxins (Fig. 2) and consist of a light chain (LC) with 50 kDa and a heavy chain (HC) with 100 kDa, which are covalently linked via a disulfide [...] 1970, seven serotypes BoNT/A-G were identified which differ in the amino acid sequence from 37.2% to 69.6% [ 5 , 6 ]. In October 2013, a new BoNT serotype HA, which is produced by a bivalent C. botulinum strain [...] HC is divided into a translocation domain HN and a receptor binding domain HC, each with 50 kDa. Scientific foci Fig. 3: Crystal structure of the 760 kDa BoNT (L-) complex [17]. BoNT/A (lilac), non-toxic

want to participate in a pulmonary function diagnosis and a fitness test, i.e. a 6-minute walk test, give a blood sample for the definition of their immune profile and answer a questionnaire. We expect [...] specific questionnaire (Fatigue Assessment Scale, FAS). In addition a testing of lung function and endurance (6-MWT) will be performed, as well a blood testing (FACS, ELISA, Neurodisorder assay) to quantify [...] beginning and are randomized in an intervention- and a waiting-control-group. After randomization patients in the intervention-group will participate in a homebased 3 month rehabilitation program using te

diseases) at Ulm University Hospital since 2000. She heads a collaborative research centre and a research group in the field of leukaemia research. She is a member of the Young Investigators Committee of the German [...] treatment concepts for this form of leukemia. They have made a significant contribution to the development of the University of Ulm into a world-leading hematology center. In addition, they have rendered [...] on colorectal cancer as a junior research group leader since 2012. Together against AML - Prof. Dr. Konstanze Döhner and Prof. Dr. Hartmut Döhner Acute myeloid leukaemia (AML) is a rare disease with 3.5

Academic Background: Molecular Genetics, Mahi-dol University, Thailand Sandra Koch Research Topic: A novel role for a viral interferon regulatory factor during the establishment of latency Supervisor: Prof. Dr [...] Research Topic: Characterization of the essential cytomegalovirus protein pUL77 as basis for the development of new antivirals and of a replication-deficient DISC-vaccine Supervisor: Prof. Dr. Martin Messerle [...] Sven Christian Sensken Research Topic: Signaltransduction of sphingosine 1-phosphate (S1P) and its receptor S1P1 in the immune system Supervisor: Dr. Markus Gräler, Institute of Immunology, Hannover Medical

(1985) A laser diffraction method for measuring muscle sarcomere length in vivo for application to tendon transfers, Fleeter, T.B., Adams, J.P., Brenner, B ., and Podolsky, R.J. J. Hand Surg. 10A, 542-546 [...] for regulation of muscle contraction, Brenner, B . Proc. Natl. Acad. Sci. USA 85, 3265-3269 (1988) A new photoelectric device for contact-free recording of diameters of short blood vessel segments in vitro [...] Chalovich, J.M., Greene, L.C., and Eisenberg, E. (H. Sugi and G.H. Pollack eds.) Plenum Publ. Corp. (1984). A technique for stabilizing the striation pattern in fully activated skinned rabbit psoas fibers, Brenner

analysis reveals that regulatory light chains fine-tune skeletal myosin-II function, Nayak A, Wang T, Franz P, Steffen W, Chizhov I, Tsiavaliaris G, Amrute-Nayak M, J Biol Chem. 2020 Apr 9. pii: jbc.RA120 [...] 31141694; PubMed Transformation of the Nonprocessive Fast Skeletal Myosin II into a Processive Motor. Amrute-Nayak M , Nayak A, Steffen W, Tsiavaliaris G, Scholz T, Brenner B. Small. 2019 Feb;15(7):e1804313 [...] regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism. Li X, Thome S, Ma X, Amrute-Nayak M , Finigan A, Kitt L, Masters L, James JR, Shi Y, Meng G, Mallat Z. Nat

incapacitated patients: A survey among German anesthesiologists and internists. BMC Medical Ethics 25:78. doi: 10.1186/s12910-024-01079-z Bratan T, Schneider D, Funer F, Heyen NB, Klausen A, Liedtke W, Lipprandt [...] Allen J, Salloch S, Suren V, Jongsma K, Braun M, Wilkinson D, Sinnott-Armstrong W, Rid A, Wendler D, Savulescu J (2024). A Personalized Patient Preference Predictor for Substituted Judgments in Healthcare: [...] J Med Internet Res, 26, e55717. https://doi.org/10.2196/55717 Salloch S, Eriksen A (2024). Some Extensions of the Loop: A Response to the Comments on Machine Learning-Driven Decision Aids. Am J Bioeth,