therapeutic application of human cardiac muscle cells, small animal models are unfortunately unsuitable, since the heart rate in these animals is much higher than in humans, and transplanted human muscle [...] Center. Here you can find further information regarding the importance of animal experiments with monkeys (German only): Animal experiments with monkeys – important questions and answers Aims of the project [...] concepts, a review of the data from in vitro studies in the living organism is inevitable. Only suitable animal models allow such therapeutic applications to be optimized and risks to be minimized before the step

s are required. These methods should allow for the tracking of the cells in not only preclinical animal models but later also in patients. In the present study, the research team led by Professor Dr. Ulrich [...] this might allow for the monitoring of survival and distribution of transplanted stem cells in both animal model and patients. In fact, using modern clinical imaging methods, these modified iPS cells could

available at our center (additional techniques can be implemented by mutual agreement): Examples of small animal PET-CT examinations: Serial 3D whole-body examination of glucose metabolism in tumor-bearing mice [...] images. Validation by ex vivo autoradiography / biodistribution measurements . Examples of small animal SPECT-CT examinations: Dopamine receptor SPECT of the basal ganglia (top left), ECG-triggered contrast

prospective recipient’s own endothelial cells. The engineered tissues being produced are tested in large animal models. Vascularized Trachea Replacements At present, there is no suitable material for repairing [...] myocardial patches are being implanted into fibrotic myocardial scar tissue. Both, small and large animal models are used for testing the practicality of this alternative approach.

utilizing hiPSC derived ECs in a SuNx PAH Rat model and development of an organ specific BMPR2 KO animal model in rats Major goal is to finally establish the new, innovative therapy concept, based on the [...] detected in 70% of the patients with familial PAH, will be addressed in a clinically more relevant animal model. Thus, a novel BMPR2 knock out (KO) rat model will be developed for evaluation of the cell [...] translate these results to human ex-vivo models and to the porcine TAC model as a clinically relevant animal model, to study the in vivo effects of a lncRNA therapy during cardiac unloading. For example, e

Models of ischemia-/reperfusion induced cholangiopathy in small and large animal models In this project, the workgroup aims to establish and characterize experimental models of ischemia-/reperfusion induced

airway disease such as asthma, COPD, fibrosis or lung infection are investigated using preclinical animal models (mouse, rat, hamster, monkey) and by using ex vivo models like precision cut lung sclices

created an information film in cooperation with the German Biobank Node (GBN) and Biobank Graz. The animated film explains the entire biobanking process in a comprehensible way, starting with patient education

hepatocytes by technologies such as gene therapy. Unfortunately, the promising results obtained in animal models could not be successfully transferred into clinical application in man, yet. The aim of our

detection of e.g. botulinum neurotoxins in an animal test replacement method for botulism diagnostics. In addition, the Rummel lab successfully operates an animal experiment replacement method for BoNT diagnostics [...] Rongsheng Jin at University of California Irvine Research The phrenic nerve hemidiaphragm assay, an animal experiment replacement method for BoNT diagnostics [3] The group leader Dr. Andreas Rumme l has been