on two continents [ 15 ]. With a molecular weight of 150 kDa, the BoNTs are classic AB toxins (Fig. 2) and consist of a light chain (LC) with 50 kDa and a heavy chain (HC) with 100 kDa, which are covalently [...] HC, each with 50 kDa. Scientific foci Fig. 3: Crystal structure of the 760 kDa BoNT (L-) complex [17]. BoNT/A (lilac), non-toxic non-hemagglutinin (NTNHA, red), hemagglutinin with 70 kDa (HA70, green / [...] / blue), hemagglutinin with 17 kDa (HA17, yellow), hemagglutinin with 33 kDa (HA33, gold). One focus of our group was and is the elucidation of the receptor entities and their interaction with binding pockets

2020 Apr 6;15(4):e0231222. doi: 10.1371/journal.pone.0231222. eCollection 2020. PubMed PMID: 32251446. * These authors contributed equally to this work Martens R, Permanyer M, Werth K, Yu K, Braun A, Halle [...] Stahl FR, Busche A, Marquardt A, Zheng X, Galla M, Heissmeyer V, Heller K, Boelter J, Wagner K, Bischoff Y, Martens R, Braun A, Werth K, Uvarovskii A, Kempf H, Meyer-Hermann M, Arens R, Kremer M, Sutter G [...] Epub 2015 Sep 5. PubMed PMID: 26348893. 2014 Ulvmar MH, Werth K, Braun A, Kelay P, Hub E, Eller K, Chan L, Lucas B, Novitzky-Basso I, Nakamura K, Rülicke T, Nibbs RJ, Worbs T, Förster R, Rot A. The atypical

Labor für Klinische Virologie im Gebäude K03(Zentrallabor) Carl-Neuberg-Str. 1, 30625 Hannover GERMANY Office hours (normal service): Monday-Friday: 07:30am - 15:30pm (Diagnostic Lab) Monday-Friday: 08:30am

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Vascul Pharmacol. *Authors contributed equally. Vasquez-Rivera, A., Sommer, K. K., Oldenhof, H., Higgins, A. Z., Brockbank, K. G. M., Hilfiker, A., and Wolkers, W. F. 2018. Simultaneous monitoring of different [...] Engineering 2020 Eyre, K., Samper, E., Haverich, A., Hilfiker, A., and Andrée, B. 2020. Re-endothelialization of non-detergent decellularized porcine vessels. Artif Organs Findeisen, K., Morticelli, L., Goecke [...] 9, Article number: 5437 Sarikouch S, Theodoridis K, Hilfiker A, Boethig D, Laufer G, Andreas M, Cebotari S, Tudorache I, Bobylev D, Neubert L, Teiken K, Robertus JL, Jonigk D, Beerbaum P, Haverich A, Horke

Salmonella-induced intestinal inflammation and prolongs colonization. PLoS Pathog. 2019;15(7):e1007915. Ehrhardt K, Steck N, Kappelhoff R, Stein S, Rieder F, Gordon IO, Boyle EC, Braubach P, Overall CM [...] serovar Typhimurium. J Infect Dis. 2019;220(6):1071-1081. Suwandi A, Galeev A, Riedel R, Sharma S, Seeger K, Sterzenbach T, García Pastor L, Boyle EC, Gal-Mor O, Hensel M, Casadesús J, Baines JF, Grassl GA. Std [...] immune responses against Salmonella infection. Front Immunol. 2018;9:2614. Schöttelndreier D, Seeger K, Grassl GA, Winny MR, Lindner R, Genth H. Expression and (lacking) internalization of the cell surface

Wendland, M., Holler, T., Piep, B., Kröhn, S., Teske, J., Bodenschatz, A.K., Devadas, S.B., Menge, K.S., Chatterjee, S., Schwanke, K., Kosanke, M., Montag, J ., Thum, T., Zweigerdt, R., Kraft, T., Iorga, [...] in hypertrophic cardiomyopathy; Montag J , Kowalski K, Makul M, Ernstberger P, Radocaj A, Beck J, Becker E, Tripathi S, Keyser B, Mühlfeld C, Wissel K, Pich A, van der Velden J, dos Remedios CG, Perrot [...] Salinas-Riester G, Legname G; BMC Genomics:15:434, 2014 Jun 2013 Mapping the Small RNA Content of Simian Immunodeficiency Virions (SIV); Brameier M, Ibing W, Höfer K, Montag J , Stahl-Hennig C, Motzkus D;

Marquez K, Mali V, Aw M, Beretta M, Van der Schyff F, Quintero-Bernabeu J, Mercadal-Hally M, Larrarte K M, Andres AM, Hernandez-Oliveros F, Frauca E, Casswall T, Jorns C, Delle M, Gupte G, Sharif K, McGuirk [...] Vaid K, Enjyoji K, Popov YV, Robson SC. Selective deletion of ENTPD1/CD39 in macrophages exacerbates biliary fibrosis in a mouse model of sclerosing cholangitis. Purinergic Signal. 2019 Sep;15(3):375-385 [...] Park JO, Rotellar F, Choi GH, Robles-Campos R, Hasegawa K, Swijnenburg RJ, Sutcliffe RP, Pratschke J, Lai ECH, Chong CCN, D'Hondt M, Monden K, Lopez-Ben S, Kingham TP, Schmelzle M , Hawksworth J, Peng