strong inhibitory and weak stimulatory signals in human immune cells when they interact with porcine tissues. Transgenic (tg) pigs expressing the human (h) inhibitory ligand hPD-L1 (CD274) and pigs lacking [...] vitro studies showed that SLA class I-deficient and hPD-L1 tg cells are only partially protected from human immune responses. We expect that hPD-L1 positive/SLA class I negative cells generated by combining

composition of sarcomeric proteins. Subcellular myofibrils can be obtained from human (e.g., biopsies), human-derived and non-human cardiac and skeletal small muscle samples (e.g., mouse, rat, rabbit, zebrafish [...] Contraction-relaxation function and mechano-chemical coupling of myofibrils Investigations of human, human pluripotent stem cell-derived cardiomyocytes and animal contractile models in non-pathologic and [...] Motorproteinen Characterization of cardiomyocytes from heart tissue and from human stem cells AG Dr. Sarah Konze Cardiomyocytes from human induced pluripotent stem cells as a cellular model for hypertrophic c

the network is establishing new tools and expertise for accelerating the development of advanced human induced pluripotent stem cell (iPSC)-based therapies. The project also aims for overcoming scientific [...] to initiate a first-in-man (FIM) clinical trial for the therapeutic administration of allogeneic, human leukocyte antigen (HLA)-homozygous iPSC-cardiomyocyte aggregates, for improving the function of damaged [...] technologies for allogenic cell therapy to the heart” will focus on overcoming general hurdles to human induced pluripotent stem cell (iPSC)-based therapies, with the particular focus on heart failure,

EU regulation no. 536/2014 (human medicine ) Thursday, 2025-27-11, 9:00 a.m. – 1:30 p.m. at CRC: Refresher for clinical trials according to EU regulation no. 536/2014 (human medicine) fee per participant [...] m. – 4:30 p.m. at CRC: Basic course for clinical trials according to EU regulation no. 536/2014 (human medicine) Tuesday, 2025-25-11 , 9:00 a.m. – 4:30 p.m. at CRC: Basic course for other clinical trials

hospitals in Germany, so it is especially valuable for research with human samples/human models. My current project works with human samples, so it is very important for me to have this research environment

does not always come easy, we are offering free access to Meditricks - especially for students of human medicine – from 1 October 2024. And this is how it works: Simply register online via Meditricks and [...] Numerous videos, mnemonics and other learning aids are available. Requirement: If you are studying human medicine at the MHH and have an AMBOSS access, you are already perfectly equipped. Where to find

IMTTS and Fraunhofer ITEM) Project: Integration and maturation of human stem cell-derived cardiomyocytes and cardiac progenitors on human myocardial slices and their role in tissue injury and regeneration [...] approach Aavani Biju Sindhu INDIA; Sindhu.Aavani @ mh-hannover.de Supervisor: Prof. Dr. Anke Bergmann (Human Genetics) Project: Characterization of molecular mechanisms driving the development and progression [...] Isabel Klefenz GERMANY; Klefenz.Isabel @ mh-hannover.de Supervisor: Prof. Dr. Doris Steinemann (Human Genetics) Project: Genetic causes of immunodeficiencies/predominantly antibody deficiencies (PADs)

team from Pediatrics and Human Genetics at Hannover Medical School (MHH) in the "Baby Lion" study. The focus is on decoding the genome, i.e. the entire genetic information of a human being, in just a few days [...] in this light, a rare disease is not so rare after all," says Dr. Bernd Auber of the Institute of Human Genetics. For the study, he and his team are focusing on a special patient group: children in their [...] first study of its kind in German-speaking countries. "Today, it is possible to completely decode the human genome in just a few days," explains Dr. Auber. Experts refer to this as whole genome sequencing (WGS)

What are lymphocytes? Lymphocytes are a fraction of white blood cells and therefore a normal part of human blood. They are used to identify pathogens and eliminate them by immunological defense mechanisms [...] system, and severe infectious diseases, in particular viruses. Lymphocytes can be obtained from human blood without preparatory measures within the framework of so-called cell separation. Procedure of

molecular signalling during respiratory differentiation of human pluripotent stem cells Complex protocols have been developed to differentiate human induced pluripotent stem cells (hiPSC) via endoderm, foregut [...] lines in RG Martin In the Martin group, iPS cells have so far been produced from cells from mice and humans , but also from various primate species (macaque, gorilla, bonobo). Various cell types produced from [...] different questions, such as the investigation of brain development. Meanwhile, a large number of human patient- or disease-specific iPS cell lines have been established in the research group. This collection