gamma-delta T cells in cord blood samples as well as from adult blood samples. "Interestingly, certain human Vγ9Vδ2 T cells are generated exclusively in the very early phase of life to be ready for immediate [...] immediate use at the time of birth and afterwards to persist as innate immune cells throughout life in humans," reports Dr Fichtner. Only recently, the team was able to show that certain gamma-delta T cells p [...] about RESIST can be found at www.RESIST-cluster.de SERVICE: The original publication "A fetal wave of human type 3 effector γδ cells with restricted TCR diversity persists into adulthood" can be found here

Prof. Dr. med. Benjamin Heidrich working group Humans are colonized by a multitude of bacteria, fungi and viruses - the so-called "human microbiome". In the digestive tract, the complexity of the microbiome [...] diseases of the biliary tract. For a long time, the biliary tract was considered a sterile niche in the human body. However, thanks to modern sequencing capabilities, we know that the biliary tract also contains

is impaired. Unlike in some amphibians and fish species, such damage is not repaired in an adult human heart. Scientists around the world are therefore working on strategies to replace destroyed heart [...] laboratory from "reprogrammed" body cells of adults and can then give rise to any cell type of the human body - including heart muscle cells. In addition to producing such cardiomyocytes from iPS cells in [...] e aggregates are now to be refined in such a way that they can also be used for heart therapy in humans. Suicide gene to prevent tumour formation This goal presents the HEAL team with very special challenges

groups that have to be taken into account in a transfusion. Tissue characteristics, the so-called human leukocyte antigens (HLA), also play a role. These molecules on the surface of body cells are comparable [...] Megakaryocyte cells produce platelets in a mouse model "We obtain the iPSCs from reprogrammed cells of a human with blood group zero, which is an ideal donor group that does not carry AB0 antigens and is therefore [...] " says Professor Figueiredo. The scientist is convinced that this should be equally successful in humans. "A living body is always the best bioreactor." There is no danger of the donor cells degenerating

the network is establishing new tools and expertise for accelerating the development of advanced human induced pluripotent stem cell (iPSC)-based therapies. The project also aims for overcoming scientific [...] to initiate a first-in-man (FIM) clinical trial for the therapeutic administration of allogeneic, human leukocyte antigen (HLA)-homozygous iPSC-cardiomyocyte aggregates, for improving the function of damaged

visceral surgery, radiotherapy, nuclear medicine, (interventional) radiology as well as pathology and human genetics, we consistently discuss every patient with gastrointestinal tumor disease when diagnostic [...] fields of gastroenterology, visceral surgery, radiology, pathology, radiotherapy, nuclear medicine and human genetics Surgical therapies (e.g. laparoscopic and/or robotic resections) by the visceral surgery [...] fields of gastroenterology, visceral surgery, radiology, pathology, radiotherapy, nuclear medicine and human genetics Surgical therapies (e.g. laparoscopic and/or robotic resections) by the visceral surgery

library among more than one million AAV variants, which function both in mouse liver cells and in human liver cells. "This cross-species application possibility is very important for the development of [...] necessary preclinical trials in the mouse model and their transfer to the later clinical trials in humans," explains the molecular biotechnologist. AAV vector variants already successful in mice against [...] have to be confirmed in further studies in large animal models and later also in clinical studies in humans. More than 400 monogenetic diseases are known for the liver. So there could be many more transport

are using heart muscle cells from human induced pluripotent stem cells. These are "reprogrammed" body cells from adults that can give rise to any cell type in the human body - including heart muscle cells [...] platform with which a COVID course can be generated that is similar and thus comparable to that of humans. The results should then explain in more detail which mechanisms the corona virus uses to weaken

anti-infectives. Microbial metagenome of the respiratory tract The Human Microbiome Project has characterized the microbiome of healthy humans in numerous organs, but has left out the lower respiratory tract [...] Pseudomonas aeruginosa lives in soil, fresh and salt water and colonizes plant and animal surfaces. In humans, P. aeruginosa has become one of the most common bacterial pathogens of local infections of the eye

development of human, stem cell-derived cardiomyocytes (hPSC-CMs) Characterization and further maturation of human, stem cell-derived cardiomyocytes (hPSC-CMs) in direct comparison with human, adult card