Future work seeks to explore the contribution of specific human genes towards bacterial pathogenesis and disease. Specifically, we focus on human signaling cascades and cellular pathways which are targeted [...] disease, current projects also focus on human genetics and infectious disease pathology. Overall, these studies are designed to answer the question why human populations exhibit variable susceptibility

Burkhard Tümmler studied biochemistry (1971-1976) and human medicine (1974-1981) and received his doctorates in the fields of physical chemistry and human genetics (Dr. rer. nat. (1979) and Dr. med. (1984)

is impaired. Unlike in some amphibians and fish species, such damage is not repaired in an adult human heart. Scientists around the world are therefore working on strategies to replace destroyed heart [...] laboratory from "reprogrammed" body cells of adults and can then give rise to any cell type of the human body - including heart muscle cells. In addition to producing such cardiomyocytes from iPS cells in [...] e aggregates are now to be refined in such a way that they can also be used for heart therapy in humans. Suicide gene to prevent tumour formation This goal presents the HEAL team with very special challenges

groups that have to be taken into account in a transfusion. Tissue characteristics, the so-called human leukocyte antigens (HLA), also play a role. These molecules on the surface of body cells are comparable [...] Megakaryocyte cells produce platelets in a mouse model "We obtain the iPSCs from reprogrammed cells of a human with blood group zero, which is an ideal donor group that does not carry AB0 antigens and is therefore [...] " says Professor Figueiredo. The scientist is convinced that this should be equally successful in humans. "A living body is always the best bioreactor." There is no danger of the donor cells degenerating

study in humans The combination has already been shown to work in human AML cell cultures and in mouse models. Now the efficacy, safety and tolerability of the new therapy are to be tested in a human clinical

gamma-delta T cells in cord blood samples as well as from adult blood samples. "Interestingly, certain human Vγ9Vδ2 T cells are generated exclusively in the very early phase of life to be ready for immediate [...] immediate use at the time of birth and afterwards to persist as innate immune cells throughout life in humans," reports Dr Fichtner. Only recently, the team was able to show that certain gamma-delta T cells p [...] about RESIST can be found at www.RESIST-cluster.de SERVICE: The original publication "A fetal wave of human type 3 effector γδ cells with restricted TCR diversity persists into adulthood" can be found here

convinced the DFG and the German Council of Science and Humanities. The German Research Foundation (DFG) and the German Council of Science and Humanities today informed Hannover Medical School (MHH) that the

the network is establishing new tools and expertise for accelerating the development of advanced human induced pluripotent stem cell (iPSC)-based therapies. The project also aims for overcoming scientific [...] to initiate a first-in-man (FIM) clinical trial for the therapeutic administration of allogeneic, human leukocyte antigen (HLA)-homozygous iPSC-cardiomyocyte aggregates, for improving the function of damaged

Zweigerdt Lab Applying human pluripotent stem cells (hPSCs) , we are working on aspects of developmental biology and regenerative medicine focused on the heart as well other tissues and lineages such as [...] Modulation of Histone Acetyl Transferases (IQ-1) and Wnt pathway (CHIR), synergistically stabilize human cardiac progenitors. SCPs depend on NR2F2 to sustain their progenitor phenotype. Upon removal of the [...] foregut endoderm tissues and a vascular network (Figure 3). Besides deciphering complex mechanisms of human organogenesis in a dish , the HFO model can also be used for replacing animal studies in the process

development of human, stem cell-derived cardiomyocytes (hPSC-CMs) Characterization and further maturation of human, stem cell-derived cardiomyocytes (hPSC-CMs) in direct comparison with human, adult card