library among more than one million AAV variants, which function both in mouse liver cells and in human liver cells. "This cross-species application possibility is very important for the development of [...] necessary preclinical trials in the mouse model and their transfer to the later clinical trials in humans," explains the molecular biotechnologist. AAV vector variants already successful in mice against [...] have to be confirmed in further studies in large animal models and later also in clinical studies in humans. More than 400 monogenetic diseases are known for the liver. So there could be many more transport

anti-infectives. Microbial metagenome of the respiratory tract The Human Microbiome Project has characterized the microbiome of healthy humans in numerous organs, but has left out the lower respiratory tract [...] Pseudomonas aeruginosa lives in soil, fresh and salt water and colonizes plant and animal surfaces. In humans, P. aeruginosa has become one of the most common bacterial pathogens of local infections of the eye

are using heart muscle cells from human induced pluripotent stem cells. These are "reprogrammed" body cells from adults that can give rise to any cell type in the human body - including heart muscle cells [...] platform with which a COVID course can be generated that is similar and thus comparable to that of humans. The results should then explain in more detail which mechanisms the corona virus uses to weaken

accumulation of mutations in somatic cells. For the first time in Germany, iPS cells were generated from human cord blood and differentiated into functional cardiomyocytes. In comparison to iPS cells derived from [...] within the scope of the annual general meeting of the GdF for their publication of iPS cells from human cord blood in the renowned journal Cell Stem Cell (Haase et al. 2009). Once a year, excellent researchers

Teilprojekt B1 Visualization of herpesviral infections and the immune response and modulation The humane cytomegalovirus (HCMV) causes, in particular in immunosuppressed patients, significant clinical diseases [...] with the murine CMV (MCMV) in the mouse, however, shows many similarities to the HCMV infection in human beings. Although comprehensive infection experiments with MCMV were carried out, the exact processes

Linden, Ricklingerstr. 5, 30449 Hannover, project: Regulation of chemokine receptor expression on human eosinophils Final exam on November 7th, 2003 (Dr.rer.nat.) Veit Erpenbeck GERMANY (Dr. med.) supervisor: [...] Sellge GERMANY supervisor: Prof. Dr. Bischoff, Gastroenterology and Hepatology, OE 6810, project: Human intestinal mast cells: versatile cells of the intestinal immune system Final exam on November 7th

"We had several winners in the running and then tested how strongly they were intercepted by the human immune system." Not all gene taxis reach their target Not all vectors that target specific body cells [...] therefore had to prove how well they could escape the neutralising antibodies in cell culture with human blood plasma. The two AAV variants also survived this test. They were then loaded with a biomolecule [...] have to be confirmed in further studies in large animal models and later also in clinical studies in humans. SERVICE: For further information, please contact Dr. Christian Bär, baer.christian@mh-hannover.de

affected by the virus. The efficacy of the drug is being tested on human lung tissue sections as well as in 3-D cell cultures from human lung epithelium. "If all this works, we will be able to use our iGUARD [...] 08.12.2021 Viruses are a major problem for human health worldwide - and not just since the outbreak of the SARS-CoV2 pandemic. Despite successful vaccine development, there are still no effective drugs

organ nevertheless remains as small and effective as possible, as is the case with the human lung. In the human lung, about 100 to 140 square meters of breathing surface are packed into 300 million alveoli [...] believes that it will be several years before the artificial lungs can be transplanted into the human body. The DFG Priority Program SPP 2014 is funding a total of ten projects throughout Germany. The

logy/ Endocrinology, OE 6819, project: Generation of a functional mouse model with a human immune system and human liver cells for the study of HCV pathogenesis and therapy; study of the functional ability [...] supervisor: Prof. Dr. Ott, Gastroenterology/Hepatology/ Endocrinology, OE 6819, project: Standardised human mesenchymal stem cells for regenerative medicine Final exam June 2010 Natalie Naue GERMANY supervisor: