the entire genome if PCD is suspected and look for the characteristic gene defects," says Dr Ringshausen. So far, more than 50 genes are known to be involved in the development of PCD. "But there are probably
Hepatology and Endocrinology, OE 6810, Project: Identification and Functional Characterization of Cancer Genes in Pancreatic Cancer. Final exam November 2019. Sofia Gialesaki GREECE Supervisor: PD Dr. Jan-Henning [...] Project: Identification and functional characterization of novel cervical cancer susceptibility genes. Final exam June 2020. Theresia Reindl GERMANY Supervisor: Prof. Dr. Dietmar Manstein, Bio-physical
the same tissue express very different proportions of mutated and wild-type mRNA of the respective gene. This most likely leads to correspondingly different proportions of mutated and wild-type protein [...] Finally, it is of great importance to elucidate mechanisms of burst-like transcription of the affected genes for sarcomeric proteins in cardiomyocytes to be able to modulate the expression, aiming at new therapeutic
family. The name DPY-19 comes from the worm C. elegans, where mutations in the C-mannosyltransferase gene lead to a temperature-sensitive DumPY phenotype. In humans there are four homologs of DPY-19, which
European Commission funded consortium: H2020-MSCA-ITN-MATURE-NK Cluster for Future: Saxocell “Cell and gene therapy”
have developed state-of-the-art next generation sequencing and systems biology approaches to examine gene expression patterns and γδ TCR repertoire information, revealing adaptive-like expansions of post
induces cachexia by impeding transcriptional signaling of the SET1/MLL complex on muscle-specific genes . iScience 27: 110913 Wang T, Nayak A , Kraft T, Amrute-Nayak M (2024) Single-Molecule Investigation [...] S (2017) Flightless-I governs cell fate by recruiting the SUMO isopeptidase SENP3 to distinct HOX genes. Epigenetics Chromatin 10: 15 Jung J, Nayak A , Schaeffer V, Starzetz T, Kirsch AK, Muller S, Dikic [...] (2017) Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator. Elife 6 Brandes RP, Harenkamp S, Schurmann C, Josipovic I, Rashid B, Rezende
(Experimental Hematology) Project: Development of novel tissue-specific AAV vectors for neuromuscular gene therapies Subham Rana , INDIA, Subham.Rana @ mh-hannover.de Supervisor: Prof. Dr. Christian Bär / [...] Lily@mh-hannover.de Supervisor: Prof. Dr. Ruthhild Weber (Human Genetics) Project: Ribosomal biogenesis genes and predisposition to brain tumors Tirthankar Saha , INDIA, Saha.Tirthankar@mh-hannover.de Supervisor:
are now to be refined in such a way that they can also be used for heart therapy in humans. Suicide gene to prevent tumour formation This goal presents the HEAL team with very special challenges. On the [...] banish the danger of unwanted tumour formation with the help of a genetic trick. "We build a suicide gene into the iPS cells that can be activated if the applied cells degenerate in the body," says Professor
Azriel S, Rokney A, Valinsky L, Rahav G, Grassl GA*, Gal-Mor O*.Differences in the expression of SPI-1 genes pathogenicity and epidemiology between the emerging Salmonella enterica serovar Infantis and the model [...] Bleich A, Johnsen JM, Vallance BA, Baines JF, Grassl GA. 2015. Expression of the blood-group-related gene B4galnt2 alters susceptibility to Salmonella infection. PLoS Pathogens. 11 e1005008. Grassl GA*, Valdez