mechanisms of vasculogenesis. In parallel, we are studying new vessel formation in human renal organoids. We have discovered that human macrophages strongly influence vascularization and endothelial differentiation [...] of renal tissue. The goal is to vascularize organoids and to produce functional kidney tissue from human stem cells. We use zebrafish embryos with genetic markers for renal cells, macrophages and endothelium
"We had several winners in the running and then tested how strongly they were intercepted by the human immune system." Not all gene taxis reach their target Not all vectors that target specific body cells [...] therefore had to prove how well they could escape the neutralising antibodies in cell culture with human blood plasma. The two AAV variants also survived this test. They were then loaded with a biomolecule [...] have to be confirmed in further studies in large animal models and later also in clinical studies in humans. SERVICE: For further information, please contact Dr. Christian Bär, baer.christian@mh-hannover.de
affected by the virus. The efficacy of the drug is being tested on human lung tissue sections as well as in 3-D cell cultures from human lung epithelium. "If all this works, we will be able to use our iGUARD [...] 08.12.2021 Viruses are a major problem for human health worldwide - and not just since the outbreak of the SARS-CoV2 pandemic. Despite successful vaccine development, there are still no effective drugs
organ nevertheless remains as small and effective as possible, as is the case with the human lung. In the human lung, about 100 to 140 square meters of breathing surface are packed into 300 million alveoli [...] believes that it will be several years before the artificial lungs can be transplanted into the human body. The DFG Priority Program SPP 2014 is funding a total of ten projects throughout Germany. The
logy/ Endocrinology, OE 6819, project: Generation of a functional mouse model with a human immune system and human liver cells for the study of HCV pathogenesis and therapy; study of the functional ability [...] supervisor: Prof. Dr. Ott, Gastroenterology/Hepatology/ Endocrinology, OE 6819, project: Standardised human mesenchymal stem cells for regenerative medicine Final exam June 2010 Natalie Naue GERMANY supervisor:
Montag J., Weber N., Kowalski K. , Mayer A.-K., Iorga B., Brunkhorst A., Zweigerdt R., Kraft T., Human pluripotent stem cell-derived cardiomyocytes mimic intercellular heterogeneity as pathomechanism in [...] Thiemann S., Schwanke K., Lingk A., Krumm U., Piep B., Martin U., Zweigerdt R., Brenner B., Kraft T., In human embryonic stem cell-derived cardiomyocytes twitsch kinetics, action potential parameters and MyH-mRNA [...] kinetics and action potential parameters are independent of expressed myosin heavy chain isoform in human embryonic stem cell-derived cardiomyocytes. 2019, Acta Physiol. 227 (S719):146 Burkart V., Beck J
10.7554/eLife.64881. Repertoire characterization and validation of gB-specific human IgGs directly cloned from humanized mice vaccinated with dendritic cells and protected against HCMV. Theobald SJ, Kreer [...] (collaboration) Polymerization of misfolded Z alpha-1 antitrypsin protein lowers CX3CR1 expression in human PBMCs. Tumpara S, Ballmaier M, Wrenger S, König M, Lehmann M, Lichtinghagen R, Martinez-Delgado B [...] 2014 Nov;44(11):3368-79. doi: 10.1002/eji.201444515. Epub 2014 Sep 19. PMID: 25100508 Activated human hepatic stellate cells induce myeloid derived suppressor cells from peripheral blood monocytes in
well-educated engineers, scientists, and clinicians To advance regenerative medicine to repair the human body following injury or disease, there is a critical need for well-educated engineers, scientists [...] , and clinicians to work jointly to translate applied research to clinical treatments to improve human health. “MHH has built a unique environment to bring all these facets together. In particular knowledge
Electrophysiological and microscopic characterisation of single neurons in neurosurgical sections of the human neokortex Investigation of Brain-Body-Interactions Development of cell culture models for translational [...] https://doi.org/10.1523/JNEUROSCI.2226-22.2023 All-trans retinoic acid induces synaptic plasticity in human cortical neurons.Lenz, M., Kruse, P., Eichler, A., Straehle, J., Beck, J., Deller, T., & Vlachos,
the dynamics of infection and immune cells with and against HCMV in an infection model of explanted human lungs. Kim Do Thi Hoang DoThiHoang.Kim @ mh-hannover.de Phone: +49 511 532 9738 Kim is part of the [...] de Phone: +49 511 532 9731 Rodrigo is focusing on characterization of the immune response of both humans and mice to prominent pathogens. His main area of expertise is spectra-flow cytometry. Dr. Swantje [...] on developing a reporter system to monitor early events of antigen-dependent T cell activation in humans. She is particularly interested in T cells and their behavior within various immune-related contexts