HZI. Mouse models reflect the human disease pattern "Tumour development in the preclinical mouse models we have established is similar to that in humans," says Dr Tetyana Yevsa. "Therefore, mouse data [...] proved to be safe and effective protection in premalignant and malignant liver diseases in preclinical mouse models. "Our Listeria-based vaccine delivers tumour-specific antigens while rapidly and efficiently

characterization of individual genetic variation of UDP-glucuronosyltransferase regulation in a mouse model Final exam November 2009 Luis Guachalla Gutierrez BOLIVIA supervisor: Prof. Dr. Rudolph, now [...] Greten, Gastroenterology/Hepatology/ Endocrinology, OE 6810, project: T cell based therapies in a mouse model of colitis associated colon cancer Final exam November 2009 Harshvardhan Rolyan INDIA supervisor: [...] PD. Dr. Rudolph, now University of Ulm project: Production and characterisation of Est1 knockout mouse. Role of Rad9/Hus1 in senescence signalling Final exam June 2009 Kathrin Steinwede GERMANY supervisor:

n of liver grafts in a porcine model. Infrastructure: Primary Human Hepatocyte (MHH) / Humanized Mouse (UKE) Core Facility Infrastructure coordinator: Florian Vondran Located at Hannover Medical School [...] studies and long-term antiviral drug evaluation. Thus, the unit recently has merged with the Humanized Mouse Platform lead by Prof. M. Dandri at UKE to serve as a new competitive technological platform enabling [...] regeneration, we combine longitudinal imaging analysis in vivo through an abdominal imaging window in the mouse with simultaneous manipulation on a single cell level. In vivo imaging of organs via endoscopic, fiber

so-called capsid variant library among more than one million AAV variants, which function both in mouse liver cells and in human liver cells. "This cross-species application possibility is very important [...] development of new therapeutic strategies, because it enables the necessary preclinical trials in the mouse model and their transfer to the later clinical trials in humans," explains the molecular biotechnologist [...] in mice against blood coagulation disorders Dr Meumann then "trained" suitable AAV variants in the mouse model. "AAV as viruses are normally ingested via the respiratory tract in nature and have to retrain

cannot be studied in the rodent model. The course of infection with the murine CMV (MCMV) in the mouse, however, shows many similarities to the HCMV infection in human beings. Although comprehensive infection [...] expression shall be clarified. By using virus mutants which do not induce a down-regulation of CCR7 and mouse mutants in case of which the expression of CCR7 can be switched on or off specifically on DC, it shall

the mouse. This area is performed in close collaboration with Fa Phenos on the MHH campus. Members of the group (Nelli Shushakowa, Rong Song) are partly employed by Phenos. We have established mouse models [...] S, Hiss M, Haller H, Shushakova N. Protein kinase C α inhibition prevents peritoneal damage in a mouse model of chronic peritoneal exposure to high-glucose dialysate: Kidney Int. 2016 Jun;89(6):1253-67

the cancer cells from growing. "We already investigated the combination of both compounds in the mouse model a few years ago and observed significant synergistic effects," says Professor Heuser. In the [...] IDH1-Mutated Acute Myeloid Leukemia" can be found here . The publication on the investigations in the mouse model "Synergistic activity of IDH1 inhibitor BAY1436032 with azacitidine in IDH1 mutant acute myeloid

U, Kuhn C, Ismail I, Warnecke G, Shrestha ML, Cebotari S, Haverich A. Cardiopulmonary bypass in a mouse model: A novel approach. J Vis Exp. 2017;(127). https://www.ncbi.nlm.nih.gov/pubmed/28994765 Napp [...] Mapping for Noninvasive Assessment of Interstitial Edema in Acute Cardiac Allograft Rejection in a Mouse Model of Heterotopic Heart Transplantation. Invest Radiol. 2017; 53:271-277. www.ncbi.nlm.nih.gov

many scientists are working with mice as a model organism, these regulations naturally also apply to mouse pathogens. Therefore every customer of our facility is obliged to fill out the bio- safety questionnaire

such as asthma, COPD, fibrosis or lung infection are investigated using preclinical animal models (mouse, rat, hamster, monkey) and by using ex vivo models like precision cut lung sclices (PCLS) in different