Working Group Seidler
Welcome to the working group of Professor Dr. Seidler.Further Information
In our IBD outpatient clinic, we treat Crohn's disease and Ulcerative Colitis as part of clinical trials.Further Information
Working group Prof. Dr. Ursula Seidler
The research focus of the working group lies in the molecular analysis of ion transport processes in the gastrointestinal tract.
Three main areas determine the activity:
- to study the molecular mechanisms of the epithelial barrier and the PH micromileau in the gastrointestinal and biliary tracts
- investigation of the regulation of epithelial ion channels and acid/base transportes in the healthy and diseased gastrointestinal tract
- investigation of the molecular analysis of compartmentalization and multiprotein signaling complex formation in the transport regulation of the gastrointestinal epithelia
In addition, we are involved in the search for new therapy options for patients with gastrointestinal complaints, e.g. Cystic fibrosis, inflammatory bowel disease and primary sclerosing cholangitis.
The working group investigates the structure-function relationships, membrane trafficking and the formation of multiprotein complexes in the regulation of intestinal acid/base transportes. Furthermore, the disorders that occur in genetic (e.g. in cystic fibrosis), infectious (e.g. in Helicobacter infection of the gastric mucosa, traveler's diarrhea) and immunological (e.g. in Crohn's disease and ulcerative colitis, after small intestine transplantation) diseases are investigated.
Fluorescent dyes, time-lapse confocal imaging, multiphoton laser scanning microscopy and the influencing of gene expression by small interfering RNA are being developed as new techniques for investigating such processes in native epithelia. Immunoprecipitation and proteomics analyzes are used to elucidate the composition of multiprotein signaling complexes in the brush border membrane.
The projects are funded by the DFG (German Research Foundation), the Ministry of Science and Culture of the State of Lower Saxony and the VW Foundation, the BMBF (Ministry of Education and Research), and various pharmaceutical companies.
Unsolicited applications from scientists, students and non-scientific staff are welcomed.
Hannover Medical School, OE 6811
Prof. Dr. med. Ursula Seidler
Dep. of Gastroenterology/Hepatology/Endocrinology
Telefon: 0511 / 532 - 9427
Mobil: 0176 / 1532 - 3355
Telefax: 0511 / 532 - 8428