Sarah Konze

Dr. rer. nat.

Copyright, MHH, MZP, Sarah Konze

Contact

Sarah Konze

Tel:  +49 511 532 -2754 (office)

Fax: +49 511 532 -4296

address: Germany 30625 Hannover, Carl-Neuberg-Str.1

building J03, floor  03, room 1330

 

 

Curriculum Vitae

 

  • Since December 2021: PostDoc at the Institute for Molecular and Cell Physiology, Hannover Medical School (MHH), Hannover, Germany
  • February 2020 – November 2021: PostDoc (fellowship funded by German Research Foundation / DFG) at the Translational Metabolic Laboratory, Department of Neurology, Radboud UMC, Nijmegen, Netherlands
  • August 2014 – January 2020: PostDoc at the Institute for Clinical Biochemistry (formerly Institute for Cellular Chemistry), MHH
  • June 2010 – July 2014: PhD at the Institute for Clinical Biochemistry Doktorarbeit within the  PhD program „Regenerative Medicine“ of the cluster of excellence „REBIRTH“
    Titel of the thesis: „Effects of Culture Conditions and Cardiomyogenic Differentiation on the (Glyco-) Proteome of Human Pluripotent Stem Cells“
  • 2010: diploma thesis at the Diplomarbeit Institute for Clinical Biochemistry, MHH in cooperation with the Institute of Microbiology, University of Veterinary Medicine, Hannover, Germany
  • 2004 - 2010 study course biochemistry at the Leibniz University, Hannover, Germany
  • 2004: high school diploma, Städtisches Mariengymnasium in Werl / Westfalen

 

Current focus of research

 

DFG-funded project: Contractile imbalance among cardiomyocytes as pathogenic factor for Hypertrophic Cardiomyopathy – investigations on human pluripotent stem-cell derived cardiomyocytes carrying MyBP-C-mutations.

The current project focuses on the characterization of induced pluripotent stem cell (iPSC)-derived cardiomyocytes carrying pathogenic mutations in the myosin binding protein C (MyBP-C). These mutations have been identified as the underlying cause of hypertrophic cardiomyopathy (HCM) in patients. With our cell models we are analyzing a potential contractile imbalance among MyBP-C-haploinsufficient cardiomyocytes causing the lesions described in the heart tissue of HCM patients. The obtained results should contribute to a better understanding of the physiological disease mechanisms and pave the way for future therapeutic approaches.

 

Expertise

 

  • Scientific expertise:
    • Cultivation and differentiation of human induced pluripotent stem cells (hiPSCs), particularly to cardiomyocytes and skeletal muscle cells
    • Characterization of hiPSCs and hiPSC-derivatives by qPCR, immunofluorescence microscopy and flow cytometry
    • Generation of disease models using CRISPR/Cas9
    • Proteomics, glycomics and metabolomics of hiPSCs and hiPSC-derived cardiomyocytes
    • Microbiological methods

 

  • Supervision of bachelor and master internships / theses for students of biochemistry and molecular biology
  • Teaching: practical courses, seminars and lectures (chemistry / biochemistry) for students of medicine