Career

• Since 2017: Principal Investigator im Institut für Molekular- und Zellphysiologie an der Medizinischen Hochschule Hannover (MHH)
• 2012-2016: Postdoctoral researcher Institute of Molecular and Cell Physiology, Medical School Hannover, Germany.
• 2008 - 2011:  Postdoctoral researcher in Medical research council- Laboratory of Molecular Biology (MRC-LMB), Cambridge, United Kingdom.
• 2003 – 2006, Ph.D. in Institute of Molecular and Cell Physiology, Medical School Hannover, Germany.
• 2001-2002, Junior research fellow in National Center for cell sciences (NCCS), Pune, India
• Master of Science (M.Sc.) from Pune University, Maharashtra, India..

Current Research Focus

• Single molecule studies of molecular motor proteins, hypertrophic cardiomyopathy (HCM) mutations in β cardiac myosin.

• Nanobiohybrid motors

• Muscle atrophy

Expertise

• Single-molecule investigations using TIRF microscopy, Optical trapping, Zero-mode waveguides.

• Teaching physiology courses (Studentisches Praktikum) for human medicine, dentistry students, and practicals for Master level biomedical students.

Publications

• Chemotherapy triggers cachexia by deregulating synergetic function of histone-modifying enzymes, Mamta Amrute-Nayak, Gloria Pegoli, Tim Holler, Alfredo Jesus Lopez-Davila, Chiara Lanzuolo, Arnab Nayak, J Cachexia Sarcopenia Muscle, . 2020 Dec 10., doi: 10.1002/jcsm.12645. Online ahead of print, PubMed
   
• Acto-Myosin Cross-Bridge Stiffness Depends on the Nucleotide State of Myosin II. Wang T, Brenner B, Nayak A, and Amrute-Nayak M. Nano Letters, 2020 Sep 15. doi: 10.1021/acs.nanolett.0c02960. [Online ahead of print] PubMed
   
• Single-molecule analysis reveals that regulatory light chains fine-tune skeletal myosin-II function, Nayak A, Wang T, Franz P, Steffen W, Chizhov I, Tsiavaliaris G, Amrute-Nayak M, J Biol Chem. 2020 Apr 9. pii: jbc.RA120.012774. doi: 10.1074/jbc.RA120.012774, PMID: 32273340, Artikel, PubMed
   
• Regulation of SETD7 Methyltransferase by SENP3 Is Crucial for Sarcomere Organization and Cachexia. Nayak A, Lopez-Davila AJ, Kefalakes E, Holler T, Kraft T, Amrute-Nayak M. Cell Rep. 2019 May 28; 27(9):2725-2736.e4. doi: 10.1016/j.celrep.2019.04.107., PMID: 31141694; PubMed

• Transformation of the Nonprocessive Fast Skeletal Myosin II into a Processive Motor. Amrute-Nayak M, Nayak A, Steffen W, Tsiavaliaris G, Scholz T, Brenner B. Small. 2019 Feb;15(7):e1804313. doi: 10.1002/smll.201804313. Epub 2019 Jan 18., PMID: 30657637; PubMed

• MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism. Li X, Thome S, Ma X, Amrute-Nayak M, Finigan A, Kitt L, Masters L, James JR, Shi Y, Meng G, Mallat Z. Nat Commun. 2017 Jun 28;8:15986. doi: 10.1038/ncomms15986., PMID: 28656979; PubMed

• ATP turnover by individual myosin molecules hints at two conformers of the myosin active site. Amrute-Nayak M, Lambeck KA, Radocaj A, Huhnt HE, Scholz T, Hahn N, Tsiavaliaris G, Walter WJ, Brenner B. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2536-41. doi: 10.1073/pnas.1316390111. Epub 2014 Feb 3., PMID: 24550279; PubMed

• Single-molecule assays reveal that RNA localization signals regulate dynein-dynactin copy number on individual transcript cargoes. Amrute-Nayak M, Bullock SL. Nat Cell Biol. 2012 Feb 26; 14(4):416-23. doi: 10.1038/ncb2446., PMID: 22366687; PubMed

• Targeted optimization of a protein nanomachine for operation in biohybrid devices. Amrute-Nayak M, Diensthuber RP, Steffen W, Kathmann D, Hartmann FK, Fedorov R, Urbanke C, Manstein DJ, Brenner B, Tsiavaliaris G. Angew Chem Int Ed Engl. 2010;49(2):312-6. doi: 10.1002/anie.200905200., PMID: 19921669; PubMed

• Inorganic phosphate binds to the empty nucleotide binding pocket of conventional myosin II. Amrute-Nayak M, Antognozzi M, Scholz T, Kojima H, Brenner B. J Biol Chem. 2008 Feb 15;283(7):3773-81. Epub 2007 Dec 12., PMID:18079122; PubMed

Third-party funding

• Deutsche Forschungsgemeinschaft (DFG)

• Fritz Thyssen Stiftung

Funding from Medical School Hannover (MHH)

• Hochschulinternen Leistungsförderung (HilF), Early career research grant.

Collaborators

• Prof. Georgios Tsiavaliaris (Biophysical chemistry, Hannover Medical School)

• Dr. Xuan Li (Cambridge, UK)

• Dr. Toshio Yanagida (Riken, Japan)

• Dr. Mitsuhiro Iwaki, (Riken, Japan)